Ilja M. Nolte

ORCID: 0000-0001-5047-4077
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Research Areas
  • Genetic Associations and Epidemiology
  • Lymphoma Diagnosis and Treatment
  • Genetic Mapping and Diversity in Plants and Animals
  • Immune Cell Function and Interaction
  • Birth, Development, and Health
  • Genetic and phenotypic traits in livestock
  • Nutrition, Genetics, and Disease
  • Cardiac electrophysiology and arrhythmias
  • Epigenetics and DNA Methylation
  • Inflammatory Bowel Disease
  • Viral-associated cancers and disorders
  • Bioinformatics and Genomic Networks
  • Child and Adolescent Psychosocial and Emotional Development
  • Cognitive Abilities and Testing
  • Obesity, Physical Activity, Diet
  • Renal and Vascular Pathologies
  • Cancer-related molecular mechanisms research
  • Asthma and respiratory diseases
  • Hormonal Regulation and Hypertension
  • Heart Rate Variability and Autonomic Control
  • Genetic Syndromes and Imprinting
  • Organ Donation and Transplantation
  • Liver Disease Diagnosis and Treatment
  • Cardiovascular Disease and Adiposity
  • Adipokines, Inflammation, and Metabolic Diseases

University Medical Center Groningen
2016-2025

University of Groningen
2016-2025

University of Bristol
2024

Bristol Regional Medical Center
2024

Massachusetts General Hospital
2024

University of Cambridge
2024

University of Tartu
2024

RELX Group (United States)
2022

Utrecht University
2021

Weatherford College
2021

Cristen J. Willer Ellen M. Schmidt Sebanti Sengupta Gina M. Peloso Stefan Gustafsson and 95 more Stavroula Kanoni Andrea Ganna Ming‐Huei Chen Martin L. Buchkovich Samia Mora J. Beckmann Jennifer L. Bragg‐Gresham Hsing‐Yi Chang Ayşe Demirkan Heleen M. den Hertog Ron Do Louise A. Donnelly Georg Ehret Tõnu Esko Mary F. Feitosa Teresa Ferreira Krista Fischer Pierre Fontanillas Ross M. Fraser Daniel F. Freitag Deepti Gurdasani Kauko Heikkilä Elina Hyppönen Aaron Isaacs Anne Jackson Åsa Johansson Toby Johnson Marika Kaakinen Johannes Kettunen Marcus E. Kleber Xiaohui Li Jian’an Luan Leo‐Pekka Lyytikäinen Patrik K. E. Magnusson Massimo Mangino Evelin Mihailov May E. Montasser Martina Müller‐Nurasyid Ilja M. Nolte Jeffrey R. O’Connell Cameron D. Palmer Markus Perola Ann-Kristin Petersen Serena Sanna Richa Saxena Susan K. Service Sonia Shah Dmitry Shungin Carlo Sidore Ci Song Rona J. Strawbridge Ida Surakka Toshiko Tanaka Tanya M. Teslovich Guðmar Þorleifsson Evita G. van den Herik Benjamin F. Voight Kelly A. Volcik Lindsay L. Waite Andrew Wong Ying Wu Weihua Zhang Devin Absher Gershim Asiki Inês Barroso Latonya Been Jennifer L. Bolton Lori L. Bonnycastle Paolo Brambilla Mary Susan Burnett Giancarlo Cesana Maria Dimitriou Alex S. F. Doney Angela Döring Paul Elliott Stephen E. Epstein Guðmundur I. Eyjólfsson Bruna Gigante Mark O. Goodarzi Harald Grallert Martha L. Gravito Christopher J. Groves Göran Hallmans Anna-Liisa Hartikainen Caroline Hayward Dena Hernández Andrew A. Hicks Hilma Hólm Yi-Jen Hung Thomas Illig Michelle R. Jones Pontiano Kaleebu John J.P. Kastelein Kay‐Tee Khaw Eric H. Kim

10.1038/ng.2797 article EN Nature Genetics 2013-10-06
Aysu Okbay Bart M. L. Baselmans Jan-Emmanuel De Neve Patrick Turley Michel G. Nivard and 95 more Mark Alan Fontana S Fleur W Meddens Richard Karlsson Linnér Cornelius A. Rietveld Jaime Derringer Jacob Gratten James J. Lee Jimmy Z. Liu Ronald de Vlaming Tarunveer S. Ahluwalia Jadwiga Buchwald Alana Cavadino Alexis C. Wood Nicholas A. Furlotte Victoria Garfield Marie Henrike Geisel Juan R Gonzalez Saskia Haitjema Robert Karlsson Sander W. van der Laan Karl-Heinz Ladwig Jari Lahti Sven J. van der Lee Penelope A. Lind Tian Liu Lindsay Matteson Evelin Mihailov Michael Miller Camelia C. Minică Ilja M. Nolte Dennis O. Mook‐Kanamori Peter J. van der Most Christopher Oldmeadow Yong Qian Olli Raitakari Rajesh Rawal Anu Realo Rico Rueedi Börge Schmidt Albert V. Smith Evie Stergiakouli Toshiko Tanaka Kent D. Taylor Gudmar Thorleifsson Juho Wedenoja Juergen Wellmann Harm-Jan Westra Sara M. Willems Wei Zhao Najaf Amin Andrew Bakshi Sven Bergmann Gyða Björnsdóttir Patricia A. Boyle Samantha Cherney Simon R. Cox Gail Davies Oliver S. P. Davis Jun Ding Neşe Direk Peter Eibich Rebecca T. Emeny Ghazaleh Fatemifar Jessica D. Faul Luigi Ferrucci Andreas J. Forstner Christian Gieger Richa Gupta Tamara B Harris Juliette Harris Elizabeth G. Holliday Jouke-Jan Hottenga Philip L De Jager Marika Kaakinen Eero Kajantie Ville Karhunen Ivana Kolčić Meena Kumari Lenore J Launer Lude Franke Ruifang Li‐Gao David C. Liewald Marisa Koini Anu Loukola Pedro Marques‐Vidal Grant W. Montgomery Miriam A. Mosing Lavinia Paternoster Alison Pattie Katja Petrovic Laura Pulkki-Råback Lydia Quaye Katri Räikkönen Igor Rudan Rodney J. Scott

10.1038/ng.3552 article EN Nature Genetics 2016-04-18
Ron Do Cristen J. Willer Ellen M. Schmidt Sebanti Sengupta Chi Gao and 95 more Gina M. Peloso Stefan Gustafsson Stavroula Kanoni Andrea Ganna Jin Chen Martin L. Buchkovich Samia Mora J. Beckmann Jennifer L. Bragg‐Gresham Hsing‐Yi Chang Ayşe Demirkan Heleen M. den Hertog Louise A. Donnelly Georg Ehret Tõnu Esko Mary F. Feitosa Teresa Ferreira Krista Fischer Pierre Fontanillas Ross M. Fraser Daniel F. Freitag Deepti Gurdasani Kauko Heikkilä Elina Hyppönen Aaron Isaacs Anne Jackson Åsa Johansson Toby Johnson Marika Kaakinen Johannes Kettunen Marcus E. Kleber Xiaohui Li Jian’an Luan Leo‐Pekka Lyytikäinen Patrik K. E. Magnusson Massimo Mangino Evelin Mihailov May E. Montasser Martina Müller‐Nurasyid Ilja M. Nolte Jeffrey R. O’Connell Colin N. A. Palmer Markus Perola Ann-Kristin Petersen Serena Sanna Richa Saxena Susan K. Service Sonia Shah Dmitry Shungin Carlo Sidore Ci Song Rona J. Strawbridge Ida Surakka Toshiko Tanaka Tanya M. Teslovich Guðmar Þorleifsson Evita G. van den Herik Benjamin F. Voight Kelly A. Volcik Lindsay L. Waite Andrew Wong Ying Wu Weihua Zhang Devin Absher Gershim Asiki Inês Barroso Latonya Been Jennifer L. Bolton Lori L. Bonnycastle Paolo Brambilla Mary Susan Burnett Giancarlo Cesana Maria Dimitriou Alex S. F. Doney Angela Döring Paul Elliott Stephen E. Epstein Guðmundur I. Eyjólfsson Bruna Gigante Mark O. Goodarzi Harald Grallert Martha L. Gravito Christopher J. Groves Göran Hallmans Anna-Liisa Hartikainen Caroline Hayward Dena Hernandez Andrew A. Hicks Hilma Hólm Yi-Jen Hung Thomas Illig Michelle R. Jones Pontiano Kaleebu John J.P. Kastelein Kay‐Tee Khaw

10.1038/ng.2795 article EN Nature Genetics 2013-10-06
Sonja I. Berndt Stefan Gustafsson Reedik Mägi Andrea Ganna Eleanor Wheeler and 95 more Mary F. Feitosa Anne E. Justice Keri L. Monda Damien C. Croteau‐Chonka Felix R. Day Tõnu Esko Tove Fall Teresa Ferreira Davide Gentilini Anne Jackson Jian’an Luan Joshua C. Randall Sailaja Vedantam Cristen J. Willer Thomas W. Winkler Andrew R. Wood Tsegaselassie Workalemahu Yi‐Juan Hu Sang Lee Liming Liang Dan-Yu Lin Josine L. Min Benjamin M. Neale Guðmar Þorleifsson Jian Yang Eva Albrecht Najaf Amin Jennifer L. Bragg‐Gresham Gemma Cadby Martin den Heijer Niina Eklund Krista Fischer Anuj Goel Jouke‐Jan Hottenga Jennifer E. Huffman Ivonne Jarick Åsa Johansson Toby Johnson Stavroula Kanoni Marcus E. Kleber Inke R. König Kati Kristiansson Zoltán Kutalik Claudia Lamina Cécile Lecœur Li Guo Massimo Mangino Wendy L. McArdle Carolina Medina‐Gómez Martina Müller‐Nurasyid Julius S. Ngwa Ilja M. Nolte Lavinia Paternoster Sonali Pechlivanis Markus Perola Marjolein J. Peters Michael Preuß Lynda M. Rose Jianxin Shi Dmitry Shungin Albert V. Smith Rona J. Strawbridge Ida Surakka Alexander Teumer Mieke D. Trip Jonathan P. Tyrer Jana V. van Vliet‐Ostaptchouk Liesbeth Vandenput Lindsay L. Waite Wei Zhao Devin Absher Folkert W. Asselbergs Mustafa Atalay Antony Attwood Anthony J. Balmforth Hanneke Basart John Beilby Lori L. Bonnycastle Paolo Brambilla Marcel Bruinenberg Harry Campbell Daniel I. Chasman Peter S. Chines Francis S. Collins John Connell William Cookson Ulf dé Fairé Femmie de Vegt Mariano Dei Maria Dimitriou Sarah Edkins Karol Estrada David M. Evans Martin Farrall Maurizio Ferrario

10.1038/ng.2606 article EN Nature Genetics 2013-04-07
John R. B. Perry Felix R. Day Cathy E. Elks Patrick Sulem Deborah J. Thompson and 95 more Teresa Ferreira Chunyan He Daniel I. Chasman Tõnu Esko Guðmar Þorleifsson Eva Albrecht Wei Ang Tanguy Corre Diana L. Cousminer Bjarke Feenstra Nora Franceschini Andrea Ganna Andrew D. Johnson Sanela Kjellqvist Kathryn L. Lunetta George McMahon Ilja M. Nolte Lavinia Paternoster Eleonora Porcu Albert V. Smith Lisette Stolk Alexander Teumer Natalia Tšernikova Emmi Tikkanen Sheila Ulivi Erin K. Wagner Najaf Amin Laura J. Bierut Enda M. Byrne Jouke‐Jan Hottenga Daniel L. Koller Massimo Mangino Tune H. Pers Laura M. Yerges-Armstrong Jing Hua Zhao Irene L. Andrulis Hoda Anton‐Culver Femke Atsma Stefania Bandinelli Matthias W. Beckmann Javier Benı́tez Carl Blomqvist Stig E. Bojesen Manjeet K. Bolla Bernardo Bonanni Hiltrud Brauch Hermann Brenner Julie E. Buring Jenny Chang‐Claude Stephen J. Chanock Jinhui Chen Georgia Chenevix‐Trench J. Margriet Collée Fergus J. Couch David Couper Andrea D. Coviello Angela Cox Kamila Czene Pio D’Adamo George Davey Smith Immaculata De Vivo Ellen W. Demerath Joe Dennis Peter Devilee Aida Karina Dieffenbach Alison M. Dunning Guðný Eiríksdóttir Johan G. Eriksson Peter A. Fasching Luigi Ferrucci Dieter Flesch‐Janys Henrik Flyger Tatiana Foroud Lude Franke Melissa E. Garcia Montserrat García‐Closas Frank Geller Eco J. C. de Geus Graham G. Giles Daníel F. Guðbjartsson Vilmundur Guðnason Pascal Guénel Suiqun Guo Per Hall Ute Hamann Robin Haring Catharina A. Hartman Andrew C. Heath Albert Hofman Maartje J. Hooning John L. Hopper Frank B. Hu David J. Hunter David Karasik Douglas P. Kiel

10.1038/nature13545 article EN Nature 2014-07-23
Felix R. Day Deborah J. Thompson Hannes Helgason Daniel I. Chasman Hilary K. Finucane and 95 more Patrick Sulem Katherine S. Ruth Sean Whalen Abhishek Sarkar Eva Albrecht Elisabeth Altmaier Marzyeh Amini Caterina Barbieri Thibaud Boutin Archie Campbell Ellen W. Demerath Ayush Giri Chunyan He Jouke‐Jan Hottenga Robert Karlsson Ivana Kolčić Po−Ru Loh Kathryn L. Lunetta Massimo Mangino Marco Brumat George McMahon Sarah E. Medland Ilja M. Nolte Raymond Noordam Teresa Nutile Lavinia Paternoster Natalia Perjakova Eleonora Porcu Lynda M. Rose Katharina E. Schraut Ayellet V. Segrè Albert V. Smith Lisette Stolk Alexander Teumer Irene L. Andrulis Stefania Bandinelli Matthias W. Beckmann Javier Benı́tez Sven Bergmann Murielle Bochud Eric Boerwinkle Stig E. Bojesen Manjeet K. Bolla Judith S. Brand Hiltrud Brauch Hermann Brenner Linda Broer Thomas Brüning Julie E. Buring Harry Campbell Eulalia Catamo Stephen J. Chanock Georgia Chenevix‐Trench Tanguy Corre Fergus J. Couch Diana L. Cousminer Angela Cox Laura Crisponi Kamila Czene George Davey Smith Eco J. C. de Geus Renée de Mutsert Immaculata De Vivo Joe Dennis Peter Devilee Isabel dos‐Santos‐Silva Alison M. Dunning Johan G. Eriksson Peter A. Fasching Lindsay Fernández‐Rhodes Luigi Ferrucci Dieter Flesch‐Janys Lude Franke Marike Gabrielson Ilaria Gandin Graham G. Giles Harald Grallert Daníel F. Guðbjartsson Pascal Guénel Per Hall Emily Hallberg Ute Hamann Tamara B. Harris Catharina A. Hartman Gerardo Heiss Maartje J. Hooning John L. Hopper Frank B. Hu David J. Hunter M. Arfan Ikram Hae Kyung Im Marjo‐Riitta Järvelin Peter K. Joshi David Karasik Manolis Kellis

10.1038/ng.3841 article EN Nature Genetics 2017-04-24
Jihua Chen Cassandra N. Spracklen Gaëlle Marenne Arushi Varshney Laura J. Corbin and 95 more Jian’an Luan Sara M. Willems Ying Wu Xiaoshuai Zhang Momoko Horikoshi Thibaud Boutin Reedik Mägi Johannes Waage Ruifang Li‐Gao Kei Hang Katie Chan Jie Yao Mila Desi Anasanti Audrey Y. Chu Annique Claringbould Jani Heikkinen Jaeyoung Hong Jouke‐Jan Hottenga Shaofeng Huo Marika Kaakinen Tin Louie Winfried März Hortensia Moreno-Macías Anne Ndungu Sarah C. Nelson Ilja M. Nolte Kari E. North Chelsea K. Raulerson Debashree Ray Rebecca Rohde Denis Rybin Claudia Schurmann Xueling Sim Lorraine Southam Isobel D. Stewart Carol A. Wang Yujie Wang Peitao Wu Weihua Zhang Tarunveer S. Ahluwalia Emil V. R. Appel Lawrence F. Bielak Jennifer A. Brody Noël P. Burtt Claudia Cabrera Brian E. Cade Jin Fang Chai Xiaoran Chai Li-Ching Chang Chien-Hsiun Chen Brian H. Chen Kumaraswamy Naidu Chitrala Yen‐Feng Chiu Hugoline G. de Haan Graciela E. Delgado Ayşe Demirkan Qing Duan Jorgen Engmann Segun Fatumo Javier Gayán Franco Giulianini Jung Ho Gong Stefan Gustafsson Yang Hai Fernando Pires Hartwig Jing He Yoriko Heianza Tao Huang Alicia Huerta-Chagoya Mi Yeong Hwang Richard A. Jensen Takahisa Kawaguchi Katherine A. Kentistou Young Jin Kim Marcus E. Kleber Ishminder K. Kooner Shuiqing Lai Leslie A. Lange Carl D. Langefeld Marie Lauzon Man Li Symen Ligthart Jun Liu Marie Loh Jirong Long Valeriya Lyssenko Massimo Mangino Carola Marzi May E. Montasser Abhishek Nag Masahiro Nakatochi Damia Noce Raymond Noordam Giorgio Pistis Michael Preuß Laura M. Raffield

10.1038/s41588-021-00852-9 article EN Nature Genetics 2021-05-31
Paolo Zanoni Sumeet A. Khetarpal Daniel B. Larach William Hancock‐Cerutti John S. Millar and 95 more Marina Cuchel Stephanie DerOhannessian Anatol Kontush Praveen Surendran Danish Saleheen Stella Trompet J. Wouter Jukema Anton de Craen Panos Deloukas Naveed Sattar Ian Ford Chris J. Packard Abdullah Al Shafi Majumder Dewan S Alam Emanuele Di Angelantonio Gonçalo R. Abecasis Rajiv Chowdhury Jeanette Erdmann Børge G. Nordestgaard Sune F. Nielsen Anne Tybjærg‐Hansen Ruth Frikke‐Schmidt Kari Kuulasmaa Dajiang J. Liu Markus Perola Stefan Blankenberg Veikko Salomaa Satu Männistö Philippe Amouyel Dominique Arveiler Jean Ferrières Martina Müller‐Nurasyid Maurizio Ferrario Frank Kee Cristen J. Willer Nilesh J. Samani Heribert Schunkert Adam S. Butterworth Joanna M. M. Howson Gina M. Peloso Nathan O. Stitziel John Danesh Sekar Kathiresan Daniel J. Rader Sarah Watson Ellen M. Schmidt Sebanti Sengupta Stefan Gustafsson Stavroula Kanoni Andrea Ganna Ming‐Huei Chen Martin L. Buchkovich Samia Mora J. Beckmann Jennifer L. Bragg‐Gresham Hsing‐Yi Chang Ayşe Demirkan Heleen M. den Hertog Ron Do Louise A. Donnelly Georg Ehret Tõnu Esko Mary F. Feitosa Teresa Ferreira Krista Fischer Pierre Fontanillas Ross M. Fraser Daniel F. Freitag Deepti Gurdasani Kauko Heikkilä Elina Hyppönen Aaron Isaacs Anne Jackson Åsa Johansson Toby Johnson Marika Kaakinen Johannes Kettunen Marcus E. Kleber Xiaohui Li Jian’an Luan Leo‐Pekka Lyytikäinen Patrik K. E. Magnusson Massimo Mangino Evelin Mihailov May E. Montasser Ilja M. Nolte Jeffrey R. O’Connell Colin N. A. Palmer Ann-Kristin Petersen Serena Sanna Richa Saxena Susan K. Service Sonia Shah Dmitry Shungin Carlo Sidore

A scavenger that protects the heart Coronary disease is a tale of two forms plasma cholesterol. In contrast to well-established effects “bad” cholesterol (LDL-C), role “good” (HDL-C) mysterious. Elevated HDL-C correlates with lower risk disease, yet drugs raise levels do not reduce risk. Zanoni et al. found some people exceptionally high carry rare sequence variant in gene encoding major receptor, receptor BI. This destroys receptor's ability take up HDL-C. Interestingly, this have higher...

10.1126/science.aad3517 article EN Science 2016-03-10

Hypertension is a heritable and major contributor to the global burden of disease. The sum rare common genetic variants robustly identified so far explain only 1%–2% population variation in BP hypertension. This suggests existence more undiscovered variants. We conducted genome-wide association study 1,621 hypertensive cases 1,699 controls follow-up validation analyses 19,845 16,541 using an extreme case-control design. locus on chromosome 16 5′ region Uromodulin (UMOD; rs13333226, combined...

10.1371/journal.pgen.1001177 article EN cc-by PLoS Genetics 2010-10-28
Pim van der Harst Weihua Zhang Irene Mateo Leach Augusto Rendon Niek Verweij and 95 more Joban Sehmi Dirk S. Paul Ulrich Elling Hooman Allayee Man Li Aparna Radhakrishnan Sian-Tsung Tan Katrin Voß Christian X. Weichenberger Cornelis A. Albers Abtehale Al-Hussani Folkert W. Asselbergs Marina Ciullo Fabrice Danjou Christian Dina Tõnu Esko David M. Evans Lude Franke Martin Gögele Jaana Hartiala Micha Hersch Hilma Hólm Jouke‐Jan Hottenga Stavroula Kanoni Marcus E. Kleber Vasiliki Lagou Claudia Langenberg Lorna M. Lopez Leo‐Pekka Lyytikäinen Olle Melander Federico Murgia Ilja M. Nolte Paul F. O’Reilly Sandosh Padmanabhan Afshin Parsa Nicola Pirastu Eleonora Porcu Laura Portas Inga Prokopenko Janina S. Ried So-Youn Shin Clara Sze-Man Tang Alexander Teumer Michela Traglia Sheila Ulivi Harm-Jan Westra Jian Yang Wei Zhao Franco Anni Abdel Abdellaoui Antony Attwood Beverley Balkau Stefania Bandinelli François Bastardot Beben Benyamin Bernhard O. Boehm William Cookson Debashish Das Paul I. W. de Bakker Rudolf A. de Boer Eco J. C. de Geus Marleen H. M. de Moor Maria Dimitriou Francisco S. Domingues Angela Döring Gunnar Engström Guðmundur I. Eyjólfsson Luigi Ferrucci Krista Fischer Renzo Galanello Stephen F. Garner Bernd Genser Quince Gibson Giorgia Girotto Daníel F. Guðbjartsson Sarah E. Harris Anna-Liisa Hartikainen Claire E. Hastie Bo Hedblad Thomas Illig Jennifer Jolley Mika Kähönen Ido P. Kema John P. Kemp Liming Liang Heather Lloyd-Jones Ruth J. F. Loos Stuart Meacham Sarah E. Medland Christa Meisinger Yasin Memari Evelin Mihailov Kathy Ann Miller Miriam F. Moffatt Matthias Nauck

10.1038/nature11677 article EN Nature 2012-12-01
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