Xueling Sim
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Nutrition, Genetics, and Disease
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Retinal Diseases and Treatments
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Genomics and Rare Diseases
- Lipid metabolism and disorders
- Glaucoma and retinal disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- BRCA gene mutations in cancer
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Corneal surgery and disorders
- Obesity, Physical Activity, Diet
- Retinal Imaging and Analysis
- Metabolism, Diabetes, and Cancer
- Nutritional Studies and Diet
National University Health System
2016-2025
National University of Singapore
2016-2025
University of Michigan–Ann Arbor
2013-2023
Curtin University
2023
Icahn School of Medicine at Mount Sinai
2023
University of Mississippi Medical Center
2020
Statistical Research (United States)
2012-2019
Genome Institute of Singapore
2006-2017
Korea National Institute of Health
2017
Agency for Science, Technology and Research
2017
Background Mild retinopathy (microaneurysms or dot-blot hemorrhages) is observed in persons without diabetes hypertension and may reflect microvascular disease other organs. We conducted a genome-wide association study (GWAS) of mild diabetes. Methods A working group agreed on phenotype harmonization, covariate selection analytic plans for within-cohort GWAS. An inverse-variance weighted fixed effects meta-analysis was performed with GWAS results from six cohorts 19,411 Caucasians. The...
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes
Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity, large number and modest effect sizes of associated variants on disease risk presence numbers neutral variants, even phenotypically relevant genes. Isolated populations with recent bottlenecks offer advantages for studying rare as they have deleterious that present at higher frequencies well a substantial reduction variation. To explore potential Finnish founder population low-frequency (0.5–5%)...
Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential provide insights into pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative phenotypes: principal analysis involved 5,717 T2D subjects, 3,345 DKD. Promising signals were evaluated up 26,827 subjects (12,710 DKD). A combined T1D+T2D GWAS was...