Xueling Sim

ORCID: 0000-0002-1233-7642
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About
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Research Areas
  • Genetic Associations and Epidemiology
  • Metabolomics and Mass Spectrometry Studies
  • Nutrition, Genetics, and Disease
  • Genetic Mapping and Diversity in Plants and Animals
  • Genetic and phenotypic traits in livestock
  • Epigenetics and DNA Methylation
  • Liver Disease Diagnosis and Treatment
  • Bioinformatics and Genomic Networks
  • Retinal Diseases and Treatments
  • Birth, Development, and Health
  • Cancer-related molecular mechanisms research
  • Genomics and Rare Diseases
  • Lipid metabolism and disorders
  • Glaucoma and retinal disorders
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Diet and metabolism studies
  • BRCA gene mutations in cancer
  • RNA modifications and cancer
  • Adipose Tissue and Metabolism
  • Pancreatic function and diabetes
  • Corneal surgery and disorders
  • Obesity, Physical Activity, Diet
  • Retinal Imaging and Analysis
  • Metabolism, Diabetes, and Cancer
  • Nutritional Studies and Diet

National University Health System
2016-2025

National University of Singapore
2016-2025

University of Michigan–Ann Arbor
2013-2023

Curtin University
2023

Icahn School of Medicine at Mount Sinai
2023

University of Mississippi Medical Center
2020

Statistical Research (United States)
2012-2019

Genome Institute of Singapore
2006-2017

Korea National Institute of Health
2017

Agency for Science, Technology and Research
2017

Georg Ehret Patricia B. Munroe Kenneth Rice Murielle Bochud Andrew D. Johnson and 95 more Daniel I. Chasman Albert V. Smith Martin D. Tobin Germaine C. Verwoert Shih Jen Hwang Vasyl Pihur Péter Vollenweider Paul F. O’Reilly Najaf Amin Jennifer L. Bragg‐Gresham Alexander Teumer Nicole L. Glazer Lenore J. Launer Jing Zhao Yurii S. Aulchenko Simon Heath Siim Sõber Afshin Parsa Jian’an Luan Pankaj Arora Abbas Dehghan Feng Zhang Gavin Lucas Andrew A. Hicks Anne Jackson John F. Peden Toshiko Tanaka Philipp S. Wild Igor Rudan Wilmar Igl Yuri Milaneschi Alex Parker Cristiano Fava John C. Chambers Ervin R. Fox Meena Kumari Min Jin Go Pim van der Harst Wen Hong Linda Kao Marketa Sjögren D. G. Vinay M Alexander Yasuharu Tabara Sue Shaw‐Hawkins Peter H. Whincup YongMei Liu Gang Shi Johanna Kuusisto Bamidele O. Tayo Mark Seielstad Xueling Sim Khanh Dung Hoang Nguyen Terho Lehtimäki Giuseppe Matullo Ying Wu Tom R. Gaunt N. Charlotte Onland‐Moret Matthew N. Cooper Carl Platou Elin Org Rebecca Hardy Santosh Dahgam Jutta Palmen Véronique Vitart Peter S. Braund Tatiana Kuznetsova Cuno S.P.M. Uiterwaal Adebowale Adeyemo Walter Palmas Harry Campbell Barbara Ludwig Maciej Tomaszewski Ioanna Tzoulaki Colin N. A. Palmer Thor Aspelund Melissa N. Garcia Yen Pei C. Chang Jeffrey R. O’Connell Nanette Steinle Diederick E. Grobbee Dan E. Arking Sharon L.R. Kardia Alanna C. Morrison Dena Hernandez Samer S. Najjar Wendy L. McArdle David Hadley Morris J. Brown John Connell Aroon D. Hingorani Ian N.M. Day Debbie A. Lawlor John Beilby Robert Lawrence Robert Clarke

10.1038/nature10405 article EN Nature 2011-09-09
Panos Deloukas Stavroula Kanoni Christina Willenborg Martin Farrall Themistocles L. Assimes and 95 more John R. Thompson Erik Ingelsson Danish Saleheen Jeanette Erdmann Benjamin A. Goldstein Kathleen Stirrups Inke R. König Jean‐Baptiste Cazier Åsa Johansson Alistair S. Hall Jong‐Young Lee Cristen J. Willer John C. Chambers Tõnu Esko Lasse Folkersen Anuj Goel Elin Grundberg Aki S. Havulinna Weang-Kee Ho Jemma C. Hopewell Niclas Eriksson Marcus E. Kleber Kati Kristiansson Per Lundmark Leo‐Pekka Lyytikäinen Suzanne Rafelt Dmitry Shungin Rona J. Strawbridge Guðmar Þorleifsson Emmi Tikkanen Natalie Van Zuydam Benjamin F. Voight Lindsay L. Waite Weihua Zhang Andreas Ziegler Devin Absher David Altshuler Anthony J. Balmforth Inês Barroso Peter S. Braund Christof Burgdorf Xueling Sim David Cox Maria Dimitriou Ron Do Alex S. F. Doney NourEddine El Mokhtari Per Eriksson Krista Fischer Pierre Fontanillas Anders Franco‐Cereceda Bruna Gigante Per‐Henrik Groop Stefan Gustafsson Jörg Hager Göran Hallmans Bok-Ghee Han Sarah Hunt Hyun Min Kang Thomas Illig Thorsten Kessler Joshua Knowles Genovefa Kolovou Johanna Kuusisto Claudia Langenberg Cordelia Langford Karin Leander Marja‐Liisa Lokki Anders Lundmark Mark I. McCarthy Christa Meisinger Olle Melander Evelin Mihailov Seraya Maouche Andrew D. Morris Martina Müller‐Nurasyid Kjell Nikus John F. Peden Nigel W. Rayner Asif Rasheed Silke Rosinger Deborah C. Rubin Moritz Rumpf Arne Schäfer Mohan U. Sivananthan Ci Song Alexandre F.R. Stewart Sian-Tsung Tan Guðmundur Þorgeirsson C. Ellen van der Schoot Peter J. Wagner George A. Wells Philipp S. Wild Tsun-Po Yang Philippe Amouyel

10.1038/ng.2480 article EN Nature Genetics 2012-12-02
Anubha Mahajan Daniel Taliun Matthias Thurner Neil R. Robertson Jason Torres and 95 more Nigel W. Rayner A. J. Payne Valgerður Steinthórsdóttir Robert A. Scott Niels Grarup James P. Cook Ellen M. Schmidt Matthias Wuttke Chloé Sarnowski Reedik Mägi Jana Nano Christian Gieger Stella Trompet Cécile Lecœur Michael Preuß Bram P. Prins Xiuqing Guo Lawrence F. Bielak Jennifer E. Below Donald W. Bowden John C. Chambers Young Jin Kim Maggie Ng Lauren E. Petty Xueling Sim Weihua Zhang Amanda J. Bennett Jette Bork‐Jensen Chad M. Brummett Mickaël Canouil Kai-Uwe Ec kardt Krista Fischer Sharon L. R. Kardia Florian Kronenberg Kristi Läll Yongmei Liu Adam E. Locke Jian’an Luan Ιωάννα Ντάλλα Vibe Nylander Sebastian Schönherr Claudia Schurmann Loïc Yengo Erwin P. Böttinger Ivan Brandslund Cramer Christensen George Dedoussis José C. Florez Ian Ford Oscar H. Franco Timothy M. Frayling Vilmantas Giedraitis Sophie Hackinger Andrew T. Hattersley Christian Herder M. Arfan Ikram Martin Ingelsson Marit E. Jørgensen Torben Jørgensen Jennifer Kriebel Johanna Kuusisto Symen Ligthart Cecilia M. Lindgren Allan Linneberg Valeriya Lyssenko Vasiliki Mamakou Thomas Meitinger Karen L. Mohlke Andrew D. Morris Girish N. Nadkarni James S. Pankow Annette Peters Naveed Sattar Alena Stančáková Konstantin Strauch Kent D. Taylor Barbara Thorand Guðmar Þorleifsson Unnur Þorsteinsdóttir Jaakko Tuomilehto Daniel R. Witte Josée Dupuis Patricia A. Peyser Eleftheria Zeggini Ruth J. F. Loos Philippe Froguel Erik Ingelsson Lars Lind Leif Groop Markku Laakso Francis S. Collins J. Wouter Jukema Colin N. A. Palmer Harald Grallert Andres Metspalu

10.1038/s41588-018-0241-6 article EN Nature Genetics 2018-10-01
Christian Fuchsberger Jason Flannick Tanya M. Teslovich Anubha Mahajan Vineeta Agarwala and 95 more Kyle J. Gaulton Clement Ma Pierre Fontanillas Loukas Moutsianas Davis J. McCarthy Manuel A. Rivas John R. B. Perry Xueling Sim Thomas W. Blackwell Neil R. Robertson Nigel W. Rayner Pablo Cingolani Adam E. Locke Juan Fernández Tajes Heather M. Highland Josée Dupuis Peter S. Chines Cecilia M. Lindgren Christopher Hartl Anne Jackson Han Chen Jeroen R. Huyghe Martijn van de Bunt Richard D. Pearson Ashish Kumar Martina Müller‐Nurasyid Niels Grarup Heather M. Stringham Eric R. Gamazon Jaehoon Lee Yuhui Chen Robert A. Scott Jennifer E. Below Peng Chen Jinyan Huang Min Jin Go Michael L. Stitzel Dorota Pasko Stephen C. J. Parker Tibor V. Varga Todd Green Nicola L. Beer Aaron G. Day‐Williams Teresa Ferreira Tasha E. Fingerlin Momoko Horikoshi Cheng Hu Iksoo Huh M. Kamran Ikram Bong-Jo Kim Yongkang Kim Young Jin Kim Min‐Seok Kwon Juyoung Lee Selyeong Lee Keng‐Han Lin Taylor J. Maxwell Yoshihiko Nagai Xu Wang Ryan Welch Joon Yoon Weihua Zhang Nir Barzilai Benjamin F. Voight Bok‐Ghee Han Christopher P. Jenkinson Teemu Kuulasmaa Johanna Kuusisto Alisa K. Manning Maggie C. Y. Ng Colin N. A. Palmer Beverley Balkau Alena Stančáková Hanna E. Abboud Heiner Boeing Vilmantas Giedraitis Dorairaj Prabhakaran Omri Gottesman Berthold Lausen Jason Carey Phoenix Kwan George Grant Joshua D. Smith Benjamin M. Neale Shaun Purcell Adam S. Butterworth Joanna M. M. Howson Heung Man Lee Yingchang Lu Soo‐Heon Kwak Wei Zhao John Danesh Vincent K. Lam Kyong Soo Park Danish Saleheen

10.1038/nature18642 article EN Nature 2016-07-11

Background Mild retinopathy (microaneurysms or dot-blot hemorrhages) is observed in persons without diabetes hypertension and may reflect microvascular disease other organs. We conducted a genome-wide association study (GWAS) of mild diabetes. Methods A working group agreed on phenotype harmonization, covariate selection analytic plans for within-cohort GWAS. An inverse-variance weighted fixed effects meta-analysis was performed with GWAS results from six cohorts 19,411 Caucasians. The...

10.1371/journal.pone.0054232 article EN cc-by PLoS ONE 2013-02-05
Lars G. Fritsche Wei Chen Matthew Schu Brian L. Yaspan Yi Yu and 95 more Guðmar Þorleifsson Donald J. Zack Satoshi Arakawa Valentina Cipriani Stephan Ripke Robert P. Igo Gabriëlle H.S. Buitendijk Xueling Sim Daniel E. Weeks Robyn H. Guymer Joanna E. Merriam Peter J. Francis Gregory Hannum Anita Agarwal Ana Maria Armbrecht Isabelle Audo Tin Aung Gaetano R. Barile Mustapha Benchaboune Alan C. Bird Paul N. Bishop Kari Branham Matthew Brooks Alexander J. Brucker William H. Cade Melinda Cain Peter A. Campochiaro Chi Chao Chan Ching‐Yu Cheng Emily Y. Chew Kimberly Chin Itay Chowers David Clayton Radu Cojocaru Yvette P. Conley Belinda K. Cornes Mark J. Daly Baljean Dhillon Albert O. Edwards Εvangelos Εvangelou Jesen Fagerness Henry Ferreyra James S. Friedman Ásbjörg Geirsdóttir Ronnie George Christian Gieger Neel Gupta Stephanie A. Hagstrom Simon Harding Christos Haritoglou John R. Heckenlively Frank G. Holz Guy Hughes John P. A. Ioannidis Tatsuro Ishibashi Peronne Joseph Gyungah Jun Yoichiro Kamatani Nicholas Katsanis Claudia N. Keilhauer Jane C. Khan Ivana K. Kim Yutaka Kiyohara Barbara E.K. Klein Ronald Klein Jaclyn L. Kovach Igor Kozak Clara J. Lee Kristine E. Lee Peter Lichtner Andrew Lotery Thomas Meitinger Paul Mitchell Saddek Mohand‐Saïd Anthony T. Moore Denise J. Morgan Margaux A. Morrison Chelsea E. Myers Adam C. Naj Yusuke Nakamura Yukinori Okada Anton Orlin Maria Carolina Ortube Mohammad Othman Chris Pappas Kyu Hyung Park Gayle J. Pauer Neal S. Peachey Olivier Poch Rinki Ratna Priya Robyn Reynolds Andrea J. Richardson Raymond Ripp Guenther Rudolph Euijung Ryu

10.1038/ng.2578 article EN Nature Genetics 2013-03-03
Jihua Chen Cassandra N. Spracklen Gaëlle Marenne Arushi Varshney Laura J. Corbin and 95 more Jian’an Luan Sara M. Willems Ying Wu Xiaoshuai Zhang Momoko Horikoshi Thibaud Boutin Reedik Mägi Johannes Waage Ruifang Li‐Gao Kei Hang Katie Chan Jie Yao Mila Desi Anasanti Audrey Y. Chu Annique Claringbould Jani Heikkinen Jaeyoung Hong Jouke‐Jan Hottenga Shaofeng Huo Marika Kaakinen Tin Louie Winfried März Hortensia Moreno-Macías Anne Ndungu Sarah C. Nelson Ilja M. Nolte Kari E. North Chelsea K. Raulerson Debashree Ray Rebecca Rohde Denis Rybin Claudia Schurmann Xueling Sim Lorraine Southam Isobel D. Stewart Carol A. Wang Yujie Wang Peitao Wu Weihua Zhang Tarunveer S. Ahluwalia Emil V. R. Appel Lawrence F. Bielak Jennifer A. Brody Noël P. Burtt Claudia Cabrera Brian E. Cade Jin Fang Chai Xiaoran Chai Li-Ching Chang Chien-Hsiun Chen Brian H. Chen Kumaraswamy Naidu Chitrala Yen‐Feng Chiu Hugoline G. de Haan Graciela E. Delgado Ayşe Demirkan Qing Duan Jorgen Engmann Segun Fatumo Javier Gayán Franco Giulianini Jung Ho Gong Stefan Gustafsson Yang Hai Fernando Pires Hartwig Jing He Yoriko Heianza Tao Huang Alicia Huerta-Chagoya Mi Yeong Hwang Richard A. Jensen Takahisa Kawaguchi Katherine A. Kentistou Young Jin Kim Marcus E. Kleber Ishminder K. Kooner Shuiqing Lai Leslie A. Lange Carl D. Langefeld Marie Lauzon Man Li Symen Ligthart Jun Liu Marie Loh Jirong Long Valeriya Lyssenko Massimo Mangino Carola Marzi May E. Montasser Abhishek Nag Masahiro Nakatochi Damia Noce Raymond Noordam Giorgio Pistis Michael Preuß Laura M. Raffield

10.1038/s41588-021-00852-9 article EN Nature Genetics 2021-05-31
Loïc Yengo Sailaja Vedantam Eirini Marouli Julia Sidorenko Eric Bartell and 95 more Saori Sakaue Marielisa Graff Anders U. Eliasen Yunxuan Jiang Sridharan Raghavan Jenkai Miao Joshua Arias Sarah E. Graham Ronen E. Mukamel Cassandra N. Spracklen Xianyong Yin Shyh‐Huei Chen Teresa Ferreira Heather H Highland Yingjie Ji Tugce Karaderi Kuang Lin Kreete Lüll Deborah E. Malden Carolina Medina‐Gómez Moara Machado Amy Moore Sina Rüeger Xueling Sim Scott Vrieze Tarunveer S. Ahluwalia Masato Akiyama Matthew Allison Marcus Alvarez Mette K. Andersen Alireza Ani Vivek Appadurai Liubov Arbeeva Seema Bhaskar Lawrence F. Bielak Sailalitha Bollepalli Lori L. Bonnycastle Jette Bork‐Jensen Jonathan P. Bradfield Yuki Bradford Peter S. Braund Jennifer A. Brody Kristoffer Sølvsten Burgdorf Brian E. Cade Hui Cai Qiuyin Cai Archie Campbell Marisa Cañadas‐Garre Eulalia Catamo Jin Fang Chai Xiaoran Chai Li-Ching Chang Yi–Cheng Chang Chien-Hsiun Chen Alessandra Chesi Seung Hoan Choi Ren‐Hua Chung Massimiliano Cocca Maria Pina Concas Christian Couture Gabriel Cuéllar-Partida Rebecca Danning E. Warwick Daw Frauke Degenhard Graciela E. Delgado Alessandro Delitala Ayşe Demirkan Xuan Deng Poornima Devineni Alexander Dietl Maria Dimitriou Latchezar Dimitrov Rajkumar Dorajoo Arif B. Ekici Jorgen Engmann Zammy Fairhurst-Hunter Aliki‐Eleni Farmaki Jessica D. Faul Juan-Carlos Fernandez-Lopez Lukas Forer Margherita Francescatto Sandra Freitag‐Wolf Christian Fuchsberger Tessel E. Galesloot Yan Gao Zishan Gao Frank Geller Olga Giannakopoulou Franco Giulianini Anette P. Gjesing Anuj Goel Scott D. Gordon Mathias Gorski Jakob Grove Xiuqing Guo

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes

10.1038/s41586-022-05275-y article EN cc-by Nature 2022-10-12

Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity, large number and modest effect sizes of associated variants on disease risk presence numbers neutral variants, even phenotypically relevant genes. Isolated populations with recent bottlenecks offer advantages for studying rare as they have deleterious that present at higher frequencies well a substantial reduction variation. To explore potential Finnish founder population low-frequency (0.5–5%)...

10.1371/journal.pgen.1004494 article EN cc-by PLoS Genetics 2014-07-31
Leslie A. Lange Youna Hu He Zhang Chenyi Xue Ellen M. Schmidt and 95 more Zheng-Zheng Tang Chris Bizon Ethan M. Lange Joshua D. Smith Emily H. Turner Goo Jun Hyun Min Kang Gina M. Peloso Paul L. Auer Kuo-ping Li Jason Flannick Ji Zhang Christian Fuchsberger Kyle J. Gaulton Cecilia M. Lindgren Adam E. Locke Alisa K. Manning Xueling Sim Manuel A. Rivas Oddgeir L. Holmen Omri Gottesman Yingchang Lu Douglas M. Ruderfer Eli A. Stahl Qing Duan Yun Li Peter Durda Shuo Jiao Aaron Isaacs Albert Hofman Joshua C. Bis Adolfo Correa Michael Griswold Jóhanna Jakobsdóttir Albert V. Smith Pamela J. Schreiner Mary F. Feitosa Qunyuan Zhang Jennifer E. Huffman Jacy R. Crosby Christina L. Wassel Ron Do Nora Franceschini Lisa W. Martin Jennifer G. Robinson Themistocles L. Assimes David R. Crosslin Elisabeth A. Rosenthal Michael Y. Tsai Mark J. Rieder Deborah Farlow Aaron R. Folsom Thomas Lumley Ervin R. Fox Christopher S. Carlson Ulrike Peters Rebecca D. Jackson Cornelia M. van Duijn André G. Uitterlinden Daniel Levy Jerome I. Rotter Herman A. Taylor Vilmundur Guðnason David S. Siscovick Myriam Fornage Ingrid B. Borecki Caroline Hayward Igor Rudan Y. Eugene Chen Erwin P. Böttinger Ruth J. F. Loos Pål Sætrom Kristian Hveem Michael Boehnke Leif Groop Mark I. McCarthy Thomas Meitinger Christie M. Ballantyne Stacey Gabriel Christopher J. O’Donnell Wendy S. Post Kari E. North Alexander P. Reiner Eric Boerwinkle Bruce M. Psaty David Altshuler Sekar Kathiresan Dan-Yu Lin Gail P. Jarvik L. Adrienne Cupples Charles Kooperberg James G. Wilson Deborah A. Nickerson Gonçalo R. Abecasis Stephen S. Rich

10.1016/j.ajhg.2014.01.010 article EN publisher-specific-oa The American Journal of Human Genetics 2014-02-01
Natalie R. van Zuydam Emma Ahlqvist Niina Sandholm Harshal Deshmukh Nigel W. Rayner and 95 more Moustafa Abdalla Claes Ladenvall Daniel Ziemek Eric B. Fauman Neil R. Robertson Paul McKeigue Erkka Valo Carol Forsblom Valma Harjutsalo Annalisa Perna Erica Rurali M. Loredana Marcovecchio Robert P. Igo Rany M. Salem Norberto Perico Maria Lajer Annemari Käräjämäki Minako Imamura Michiaki Kubo Atsushi Takahashi Xueling Sim Jianjun Liu Rob M. van Dam Guozhi Jiang Claudia H.T. Tam Andrea O. Y. Luk Heung Man Lee Cadmon K.P. Lim Cheuk‐Chun Szeto Wing Yee So Juliana C.N. Chan Su Fen Ang Rajkumar Dorajoo Ling Wang Tan Si Hua Clara Amy Jayne McKnight Seamus Duffy Marcus G. Pezzolesi Michel Marre Beata Gyorgy Samy Hadjadj Linda T. Hiraki Tarunveer S. Ahluwalia Peter Almgren Christina‐Alexandra Schulz Marju Orho‐Melander Allan Linneberg Cramer Christensen Daniel R. Witte Niels Grarup Ivan Brandslund Olle Melander Andrew D. Paterson David‐Alexandre Trégouët Alexander P. Maxwell Su Chi Lim Ronald C.W. E Shyong Tai Shiro Maeda Valeriya Lyssenko Jaakko Tuomilehto Andrzej S. Królewski Stephen S. Rich Joel N. Hirschhorn José C. Florez David B. Dunger Oluf Pedersen Torben Hansen Peter Rossing Giuseppe Remuzzi M. Julia Brosnan Colin N. A. Palmer Per‐Henrik Groop Helen M. Colhoun Leif Groop Mark I. McCarthy Satu Koivula T. Uggeldahl Terje Forslund A. Halonen A. Koistinen P. Koskiaho M. Laukkanen Juha Saltevo Miia Tiihonen M. Forsen Helena Granlund A.-C. Jönsson B. Nyroos Pentti Kinnunen A. Orvola Tapani Salonen A. Vähänen Kotka R. Paldanius M Riihelä

Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential provide insights into pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative phenotypes: principal analysis involved 5,717 T2D subjects, 3,345 DKD. Promising signals were evaluated up 26,827 subjects (12,710 DKD). A combined T1D+T2D GWAS was...

10.2337/db17-0914 article EN Diabetes 2018-04-27
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