A5072298001- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Intraocular Surgery and Lenses
- Optical Coherence Tomography Applications
- Retinopathy of Prematurity Studies
- Ocular and Laser Science Research
- Vascular Malformations Diagnosis and Treatment
- Ophthalmology and Visual Impairment Studies
- Neuroscience and Neural Engineering
- Ocular Oncology and Treatments
- Connexins and lens biology
- Neonatal Respiratory Health Research
- HIV Research and Treatment
- Cytomegalovirus and herpesvirus research
- Retinoids in leukemia and cellular processes
- Neonatal Health and Biochemistry
- Systemic Lupus Erythematosus Research
- Corneal Surgery and Treatments
- Ocular Infections and Treatments
- Ocular Surface and Contact Lens
University of Arizona
2024-2025
Abu Dhabi Falcon Hospital
2025
University College London
2018-2024
Moorfields Eye Hospital
2018-2024
Danat Al Emarat Women & Children’s Hospital
2020-2024
Tianjin Medical University Eye Hospital
2023
Tianjin Medical University
2023
Inserm
2023
Université de Bordeaux
2023
Singapore National Eye Center
2023
The rs1061170T/C variant encoding the Y402H change in complement factor H (CFH) has been identified by genome-wide association studies as being significantly associated with age-related macular degeneration (AMD). However, precise mechanism which this CFH impacts risk of AMD remains largely unknown. Oxidative stress plays an important role many aging diseases, including cardiovascular disease and AMD. A large amount oxidized phospholipids (oxPLs) are generated eye because sunlight exposure...
Genome-wide association study (GWAS) has identified genetic variants in the promoter region of high temperature requirement factor A1 (HTRA1) gene associated with age-related macular degeneration (AMD). As a secreted serine protease, HTRA1 been reported to interact members transforming growth factor-β (TGF-β) family and regulate their signaling pathways. Growth differentiation 6 (GDF6), member TGF-β family, is involved ectoderm patterning eye development. Mutations GDF6 have abnormal...
The purpose of this study was to determine the morphologic patterns angiographic macular edema using simultaneous colocalization fluorescein angiography and spectral-domain optical coherence tomography (SD-OCT) images in diabetes, epiretinal membrane, uveitic pseudophakic cystoid edema, vein occlusion.Eighty-seven consecutive patients (107 eyes) with from 5 different etiologies were imaged by scanning laser ophthalmoscopy/OCT on SD-OCT then correlated/colocalized leakage. Statistical...
Objectives: To evaluate the independent and joint effects of genetic factors environmental variables on advanced forms age-related macular degeneration (AMD), including geographic atrophy choroidal neovascularization, to develop a predictive model with included.Methods: Demographic information, age at onset, smoking status, body mass index, was collected for 1844 participants.Genotypes were evaluated 8 variants in 5 genes related AMD.Unconditional logistic regression analyses performed...
Drusen are the hallmark of age-related macular degeneration (AMD), and substantial evidence exists that amount drusen their effect on retinal pigment epithelium is a strong predictor progression AMD vision loss. Until recently, it was not possible to quantitate volume drusen. However, use image-stabilized scanning laser ophthalmoscope or spectral domain-optical coherence tomography (OCT) has enabled determination this abnormal material. The purpose study assess correlation with Age-Related...
In Brief Purpose: To compare high-resolution optical coherence tomography (OCT) and fluorescein angiography (FA) in detection of macular edema (ME) various etiologies. Methods: a retrospective study over 12-month period at one retina center, data for consecutive eyes that had undergone simultaneous conventional FA (HRA; Heidelberg Engineering, Vista, CA) StratusOCT (Carl Zeiss Meditec, Dublin, to rule out ME were reviewed. A subset patients underwent additional examination with extremely...
Age-related macular degeneration (AMD) is a leading cause of visual impairment in aging populations industrialized countries. Here we investigated whether the genotype vascular endothelial growth factor A (VEGFA) gene associated with response to anti-VEGF therapy. 223 eyes neovascular AMD were treated intravitreal Responders defined as patients who had an improvement best corrected acuity (BCVA) at least 5 letters or one line on EDTRS chart along resolution intraretinal subretinal fluid over...
The purpose of the study was to assess both anatomic and functional outcomes between short-pulse continuous wavelength infrared micropulse lasers in treatment DME. This a prospective interventional from tertiary care eye hospital-King Khaled Eye Specialist Hospital (Riyadh, Saudi Arabia). Patients with center-involving diabetic macular edema were treated subthreshold laser therapy. group 810-nm diode scanning TxCell (IRIDEX Corporation, Mountain View, CA, USA) (subthreshold micropulse-STMP...
In the United Arab Emirates, retinopathy has been shown to be present in 19% of diabetic population, with diabetes identified up 40% individuals aged over 55 years. Despite prevalence retinal diseases, there are no unified national guidelines on management macular edema (DME). These published based evidence taken from literature and trials therapies, consensus opinion a representative expert panel an interest this condition, convened by Emirates Society Ophthalmology. The aim is provide...
In Brief Purpose: To compare standardized visual outcomes and macular thickness changes associated with primary secondary bevacizumab (Avastin; Genentech, Inc., South San Francisco, CA) therapy for choroidal neovascularization (CNV) in age-related degeneration (AMD). Methods: Eighteen eyes received treatment; 20 pegaptanib (Macugen; Eyetech/OSI Pharmaceuticals, New York, NY) as initial treatment followed by therapy. Both medications were injected at 6-week intervals. Best-corrected acuity...
In Brief Purpose: To evaluate the response to primary bevacizumab treatment of eyes with age-related macular degeneration (AMD) and choroidal neovascularization (CNV) a large pigment epithelial detachment (PED) component compare increase in visual acuity reabsorption retinal fluid PED CNV AMD minimal no component. Methods: We reviewed 43 consecutive on therapy. There were 13 30 CNV. Only patients previous for those started purely intravitreal taken study. Pigment size, time collapse, or...
To describe the natural history of eyes with symptomatic idiopathic vitreomacular traction (VMT).Retrospective multicenter study 168 spectral-domain optical coherence tomography (SD-OCT) findings consistent VMT. All were graded according to SD-OCT findings. Grade 1 was defined as incomplete cortical vitreous separation foveal attachment. 2 plus intraretinal cysts or clefts. 3 a detachment. patients followed for at least 6 months.There (51 men) mean age 68.8 ± 10.7 years. Patients 22.7 20.1...