A5100457607- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Nuclear Structure and Function
- Plant Genetic and Mutation Studies
- Ocular Surface and Contact Lens
- Retinal Development and Disorders
- NF-κB Signaling Pathways
- Reconstructive Surgery and Microvascular Techniques
- Respiratory Support and Mechanisms
- RNA Research and Splicing
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Retinal Imaging and Analysis
- Protease and Inhibitor Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- RNA modifications and cancer
- Lipid metabolism and biosynthesis
- Intraocular Surgery and Lenses
- MicroRNA in disease regulation
- Sulfur Compounds in Biology
Peking University People's Hospital
2007-2025
Peking University
2007-2025
National Clinical Research Center for Digestive Diseases
2025
Guangxi Medical University
2025
Hebei Medical University
2017-2024
Fourth Hospital of Hebei Medical University
2018-2024
Sun Yat-sen University
2013-2024
Versiti Blood Center of Wisconsin
2011-2024
Fudan University
2012-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
The function of mitophagy in cancer is controversial. ULK1 critical for induction macroautophagy/autophagy and has a more specific role response to hypoxia. Here, we show that deficiency induces an invasive phenotype breast cells under hypoxia increases osteolytic bone metastasis. Mechanistically, depletion attenuates ability during As result, the accumulation damaged, ROS-generating mitochondria leads activation NLRP3 inflammasome, which abnormal soluble cytokines secretion, then promotes...
Macroautophagy/autophagy plays an important role during the development of human cancer. BECN1 (beclin 1), a core player in autophagy regulation, is downregulated many kinds malignancy. The underlying mechanism, however, has not been fully illuminated. Here, we found that CUL3 (cullin 3), E3 ubiquitin ligase, could interact with and promote K48-linked ubiquitination degradation this protein; In addition, led to decrease autophagic activity through downregulating BECN1. We also KLHL38 was...
Abstract Most patients with triple negative breast cancer (TNBC) do not respond to anti-PD1/PDL1 immunotherapy, indicating the necessity explore immune checkpoint targets. B7H3 is a highly glycosylated protein. However, mechanisms of glycosylation regulation and whether sugar moiety contributes immunosuppression are unclear. Here, we identify aberrant show that N-glycosylation at NXT motif sites responsible for its protein stability in TNBC tumors. The fucosyltransferase FUT8 catalyzes core...
Ferroptosis, an iron-dependent lipid peroxidation-driven programmed cell death, is closely related to cancer therapy. The development of druggable ferroptosis inducers and their rational application in therapy are critical. Here, we identified Tubastatin A, HDAC6 inhibitor as a novel inducer through large-scale drug screening. A directly bonded GPX4 inhibited enzymatic activity biotin-linked putdown LC/MS analysis, which independent its inhibition HDAC6. In addition, our results showed that...
BackgroundEffective targets for systolic blood-pressure control in patients with type 2 diabetes are unclear.MethodsWe enrolled 50 years of age or older diabetes, elevated blood pressure, and an increased risk cardiovascular disease at 145 clinical sites across China. Patients were randomly assigned to receive intensive treatment that targeted a pressure less than 120 mm Hg standard 140 up 5 years. The primary outcome was composite nonfatal stroke, myocardial infarction, hospitalization...
Familial macular degeneration is a clinically and genetically heterogeneous group of disorders characterized by progressive central vision loss. Here we show that an R373C missense mutation in the prominin 1 gene (PROM1) causes 3 forms autosomal-dominant degeneration. In transgenic mice expressing mutant human PROM1, both endogenous PROM1 were found throughout layers photoreceptors, rather than at base photoreceptor outer segments, where normally localized. Moreover, segment disk membranes...
Age-related macular degeneration is the most common cause of irreversible visual impairment in developed world. Advanced age-related consists geographic atrophy and choroidal neovascularization. The specific genetic variants that predispose patients to are largely unknown.We tested for an association between functional toll-like receptor 3 gene (TLR3) variant rs3775291 (involving substitution phenylalanine leucine at amino acid 412) Americans European descent. We also effect TLR3 Leu Phe on...
In order to investigate the protective mechanism of hydrogen sulfide (H2S) in sepsis-associated acute kidney injury (SA-AKI), ten AKI patients and healthy controls were enrolled. patients, levels creatinine (Cre), urea nitrogen (BUN), tumor necrosis factor-α (TNF-α) interleukin-1β (IL-1β), myeloperoxidase (MPO) activity as well concentrations malondialdehyde (MDA) peroxide (H2O2) significantly increased compared with those controls. However, plasma level H2S decreased was linearly correlated...
Abstract Most triple-negative breast cancer (TNBC) patients fail to respond T cell-mediated immunotherapies. Unfortunately, the molecular determinants are still poorly understood. Breast is disease genetically linked a deficiency in autophagy. Here, we show that autophagy defects TNBC cells inhibit tumour killing vitro and vivo. Mechanistically, identify Tenascin-C as candidate for deficiency-mediated immunosuppression, which Lys63-ubiquitinated by Skp2, particularly at Lys942 Lys1882, thus...
Abstract Recent studies have reported the role of Wnt/ β -catenin signaling in hair cell (HC) development, regeneration, and differentiation mouse cochlea; however, HC protection remains unknown. In this study, we took advantage transgenic mice to specifically knockout or overactivate canonical Wnt mediator HCs, which allowed us investigate protecting HCs against neomycin-induced damage. We first showed that loss made them more vulnerable injury, while constitutive activation reduced both...
Control of chronic viral infections by CD8 T cells is critically dependent on CD4 help. In particular, helper-derived IL-21 plays a key role in sustaining the cell response; however, molecular pathways which sustains immunity remain unclear. We demonstrate that causes phenotypic switch transcription factor expression during infection characterized sustained BATF expression. Importantly, both required for optimal persistence and anti-viral effector function sufficient to rescue "unhelped"...
Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is complex disease with significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls replication the most findings in 9173 26 780 across 18 collections Asian, African European descent. Apart from confirming strong evidence association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P 2.81 × 10−33), we observed one SNP showing to (CDC7–TGFBR3 rs1192415,...
NAC (NAM, ATAF, and CUC) transcription factors are important regulator in abiotic stress plant development. However, knowledge concerning the functions of TFs functioning tolerance underlying molecular basis still limited. In this study, we report functional characterization TF, PbeNAC1, isolated from Pyrus betulifolia. PbeNAC1 were greatly induced by cold drought, while salt had little effect on expression. was localized nuclei showed transactivation activity. Overexpression conferred...
Abstract Many cancer drugs are toxic to cells by activating apoptotic pathways. Previous studies have shown that mitochondria key roles in apoptosis mammalian cells, but the role of mitochondrial DNA (mtDNA) copy number variation pathogenesis tumor cell remains largely unknown. We used HEp-2, HNE2, and A549 lines explore relationship between mtDNA apoptosis. first induced three one normal adult human skin fibroblast line (HSF) with cisplatin (DDP) or doxorubicin (DOX) treatment found...