A5043999248- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Immune Cell Function and Interaction
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Urticaria and Related Conditions
- Mast cells and histamine
- Rheumatoid Arthritis Research and Therapies
- Anesthesia and Neurotoxicity Research
- Dermatology and Skin Diseases
- Digestive system and related health
- Chemokine receptors and signaling
- Inflammatory Bowel Disease
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Immunotherapy and Biomarkers
- Inflammasome and immune disorders
- Fluid Dynamics and Mixing
- Bone Metabolism and Diseases
- Immune cells in cancer
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- Bone and Dental Protein Studies
- Immunotherapy and Immune Responses
Shanghai Jiao Tong University
2016-2025
Sichuan University
2025
West China Second University Hospital of Sichuan University
2025
Shanghai Tenth People's Hospital
2014-2024
Tongji University
2013-2024
Shandong University of Technology
2023-2024
Shanghai Chest Hospital
2021-2022
Shanghai Sixth People's Hospital
2020
Institute of Immunology
2015
Shanghai East Hospital
2014
The four major RNA adenosine modifications, i.e., m
Interleukin-17F (IL-17F), produced by Th17 cells and other immune cells, is a member of IL-17 cytokine family with highest homology to IL-17A. IL-17F has been shown have multiple functions in inflammatory responses. While IL-17A plays important roles cancer development, the function tumorigenesis not yet elucidated. In current study, we found that expressed normal human colonic epithelial but this expression greatly decreased colon tissues. To examine cancer, used over-expressing cell lines...
Abstract Mast cells are phenotypically and functionally heterogeneous, their state is possibly controlled by local microenvironment. Therefore, specific analyses needed to understand whether mast function as powerful participants or dispensable bystanders in diseases. Here, we show that degranulation of inflammatory synovial tissues patients with rheumatoid arthritis (RA) induced via MAS-related G protein-coupled receptor X2 (MRGPRX2), the expression MHC class II costimulatory molecules on...
IFN-beta currently serves as one of the major treatments for MS. Its anti-inflammatory mechanism has been reported involving a shift in cytokine balance from Th1 to Th2 T-cell response against elements myelin sheath. In addition and groups, two other important pro-inflammatory cytokines, IL-17 osteopontin (OPN), are believed play roles CNS inflammation pathogenesis this study, we examined potential effects on regulation OPN MS patients. We found that used vitro at 0.5-3 ng/mL significantly...
Abstract Objective Osteopontin (OPN) that is aberrantly produced in rheumatoid synovium thought to play an important role arthritis (RA). This study was undertaken investigate the of OPN differentiation and accumulation Th17 cells synovium. Methods Peripheral blood mononuclear purified CD4+ T derived from patients with RA or healthy controls were used test effect vitro. Cytokine expression determined by enzyme‐linked immunosorbent assay quantitative polymerase chain reaction. Intracellular...
Summary Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is an independent risk factor for the development of erectile dysfunction (ED). But molecular mechanisms underlying relationship between CP/CPPS and ED are still unclear. The aim this study was to investigate effect on function in a rat model possible mechanisms. A experimental autoimmune prostatitis (EAP) established mimic human CP⁄CPPS. Then twenty 2‐month‐old male Sprague–Dawley rats were divided into EAP group control...
Objective . To expand upon the role of iguratimod (T‐614) in treatment rheumatoid arthritis (RA), we investigated whether Th1, Th17, follicular helper T cells (Tfh), and regulatory (Treg) imbalance could be reversed by clinical implications this reversal. Methods In trial, 74 patients were randomized into iguratimod‐treated (group A) control (broup B) group for a 24‐week period. subsequent 28 weeks, both groups given iguratimod. Frequencies Tfh, Treg quantified using flow cytometry, serum...
Abstract Imbalance of macrophage polarization plays an indispensable role in acute lung injury (ALI), which is considered as a promising target. Matrix metalloproteinase-9 (MMP-9) expressed the macrophage, and has pivotal secreting inflammatory cytokines. We reported that saquinavir (SQV), first-generation human immunodeficiency virus-protease inhibitor, restricted exaggerated response. However, whether MMP-9 could regulate inhibit by SQV still unknown. focused on important CLP (cecal...
Abstract Excessive host immune responses contribute to severe malaria with high mortality. Here, we show that PRL2 in innate cells is highly related experimental disease progression, especially the development of murine malaria. In absence myeloid cells, Plasmodium berghei infection results augmented lung injury, leading significantly increased Intravital imaging revealed greater neutrophilic inflammation and NET formation lungs conditional knockout mice. Depletion neutrophils prior onset...
The aim of this retrospective clinical study is to assess outcomes and patient satisfaction between laparoscopic lateral suspension (LLS) with mesh high uterosacral ligament (LHUS) for apical prolapse or without anterior prolapse. Patients who underwent LLS LHUS from 2019 2023 at the Second West China Hospital Sichuan University were enrolled in study. objective evaluated on basis anatomical success rate according Pelvic Organ Prolapse Quantification System (POP-Q). subjective assessed using...
Abstract Mast cells play a central role in allergic reactions, acting as key effector that initiate and amplify the inflammatory response. In this study, we demonstrate phosphatase of regenerating liver 2 (PRL2) functions negative regulator FcεRI-mediated mast cell activation. PRL2-deficient myeloid cells, PRL2 conditional knockout mice developed more severe passive systemic anaphylaxis (PSA). Although deficiency does not impact development, absence activation is enhanced. presence IgE...