A5040681915- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Single-cell and spatial transcriptomics
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Immune cells in cancer
- Science, Research, and Medicine
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Skin Protection and Aging
- Ferroptosis and cancer prognosis
- IL-33, ST2, and ILC Pathways
- Nanoplatforms for cancer theranostics
- Collagen: Extraction and Characterization
- Angiogenesis and VEGF in Cancer
- Dermatologic Treatments and Research
- Eosinophilic Esophagitis
- Inflammatory Bowel Disease
- Peptidase Inhibition and Analysis
Ruijin Hospital
2023-2024
Shanghai Jiao Tong University
2021-2024
State Key Laboratory of Oncogene and Related Genes
2023
Renji Hospital
2023
Shanghai Chest Hospital
2023
Abstract Colorectal cancer (CRC) is among the most common malignancies with limited treatments other than surgery. The tumor microenvironment (TME) profiling enables discovery of potential therapeutic targets. Here, we profile 54,103 cells from and adjacent tissues to characterize cellular composition elucidate origin regulation tumor-enriched cell types in CRC. We demonstrate that tumor-specific FAP + fibroblasts SPP1 macrophages were positively correlated 14 independent CRC cohorts...
The four major RNA adenosine modifications, i.e., m
Abstract Although advances in spatial transcriptomics (ST) enlarge to unveil landscape of tissues, it remains challenging delineate pathology-relevant and cellular localizations, interactions exclusive a niche (e.g., tumor boundary). Here, we develop Cottrazm, integrating ST with hematoxylin eosin histological image, single-cell the boundary connecting malignant non-malignant cell spots deconvolute cell-type composition at location, reconstruct type-specific gene expression profiles sub-spot...
Abstract The tumor microenvironment (TME) represents a complex network in which cells communicate not only with each other but also stromal and immune cells. intercellular interactions the TME contribute to initiation, progression, metastasis, treatment outcome. Recent advances spatial transcriptomics (ST) have revolutionized molecular understanding of at level. A comprehensive interactive analysis resource specifically designed for characterizing could facilitate further using ST. In this...
Intestinal fibrosis, a severe complication of Crohn's disease (CD), is characterized by excessive extracellular matrix (ECM) deposition and induces intestinal strictures, but there are no effective anti-fibrosis drugs available for clinical application. We performed single-cell RNA sequencing (scRNA-seq) fibrotic non-fibrotic ileal tissues from CD patients with obstruction. Analysis revealed mesenchymal stromal cells (MSCs) as the major producers ECM increased infiltration its subset FAP+...
Abstract Stromal cells are physiologically essential components of the tumor microenvironment (TME) that mediates development and therapeutic resistance. Development a logical unified system for stromal cell type identification characterization corresponding functional properties could help design antitumor strategies target cells. Here, we performed pan-cancer analysis 214,972 nonimmune using single-cell RNA sequencing from 258 patients across 16 cancer types analyzed spatial...
Although hypoxia is known to be associated with immune resistance, the adaptability by different cell populations in tumor microenvironment and underlying mechanisms remain elusive. This knowledge gap has hindered development of therapeutic strategies overcome resistance induced hypoxia. Here, bulk, single-cell, spatial transcriptomics are integrated characterize escape during carcinogenesis reveal a hypoxia-based intercellular communication hub consisting malignant cells, ALCAM
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<div>Abstract<p>Stromal cells are physiologically essential components of the tumor microenvironment (TME) that mediates development and therapeutic resistance. Development a logical unified system for stromal cell type identification characterization corresponding functional properties could help design antitumor strategies target cells. Here, we performed pan-cancer analysis 214,972 nonimmune using single-cell RNA sequencing from 258 patients across 16 cancer types analyzed...
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<div>Abstract<p>Stromal cells are physiologically essential components of the tumor microenvironment (TME) that mediates development and therapeutic resistance. Development a logical unified system for stromal cell type identification characterization corresponding functional properties could help design antitumor strategies target cells. Here, we performed pan-cancer analysis 214,972 nonimmune using single-cell RNA sequencing from 258 patients across 16 cancer types analyzed...
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