A5066081016- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hormonal and reproductive studies
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Liver Disease and Transplantation
- Prostate Cancer Treatment and Research
- Neurological Disease Mechanisms and Treatments
- Foreign Body Medical Cases
- Lipid metabolism and disorders
- Ubiquitin and proteasome pathways
- Genetic Neurodegenerative Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Renal cell carcinoma treatment
- TGF-β signaling in diseases
- Prostate Cancer Diagnosis and Treatment
University of Science and Technology of China
2021-2025
Tianjin University of Traditional Chinese Medicine
2024
Jilin University
2020-2023
Chinese PLA General Hospital
2023
First Hospital of Jilin University
2023
Tianjin Nankai Hospital
2014-2021
Union Hospital
2020
Tianjin Hospital
2020
Tianjin Medical University
2016
Liver venous deprivation (LVD; simultaneous portal vein embolization and hepatic embolization) has been the latest surgical strategy for rapid future liver remnant (FLR) hypertrophy. The aim of this study was to assess feasibility, safety, efficacy LVD following arterial chemoembolization (TACE-LVD) before major hepatectomy hepatocellular carcinoma (HCC). A retrospective analysis outcomes 23 HCC patients who underwent TACE-LVD at our center between October 2019 2023 conducted. An assessment...
RNA processing converts primary transcript into mature RNA. Altered drives tumor initiation and maintenance, may generate novel therapeutic opportunities. However, the role of factors in gastric cancer (GC) has not been clearly elucidated. This study presents a comprehensive analysis exploring clinical, molecular, immune, drug response features underlying GC. included 1079 GC cases from The Cancer Genome Atlas (TCGA, training set), our hospital cohort, two other external validation sets...
Abstract Interferon (IFN) exerts its effects through interferon-stimulated genes (ISGs), but efficacy is limited by interferon resistance, which can be caused the ubiquitination of key proteins. UBE2O was initially identified as a promising therapeutic target based on data from TCGA and iUUCD 2.0 databases. Through inhibition UBE2O, α/β signaling overall were activated. Integrating proteomic, mass spectrometry, survival analyses led to identification IFIT3, mediator signaling, substrate...
Aims: Emerging evidence is demonstrating that rapid regeneration of remnant liver elicited by associating partition and portal vein ligation for staged hepatectomy (ALPPS) may be attenuated in fibrotic livers. However, the molecular mechanisms responsible this process are largely unknown. It widely acknowledged TGFβ1 signaling axis plays a major role fibrosis. Therefore, aims study were to elucidate underlying mechanism during ALPPS with or without fibrosis, specifically focusing on...
Abstract Glutamine addiction represents a metabolic vulnerability of cancer cells; however, effective therapeutic targeting the pathways involved remains to be realized. Here, we disclose critical role interferon-related developmental regulator 1 (IFRD1) in adaptive survival hepatocellular carcinoma (HCC) cells during glutamine starvation. IFRD1 is induced under starvation inhibit autophagy by promoting proteasomal degradation key ATG14 TRIM21-dependent manner. Conversely, glutamine-deprived...
Ischemic stroke is divided into acute phase, subacute and recovery with different pathological physiological characteristics manifested at each stage. Among them, immune inflammatory reactions persist for several days weeks after ischemia. not only triggers local inflammation in damaged brain regions but also induces a disorder the system, thereby promoting neuroinflammation exacerbating damage. Therefore, conducting an in-depth analysis of interaction between central nervous system ischemic...
To date, carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic (CEA) have been widely used for the screening, diagnosis prediction of biliary tract cancer (BTC) patients. However, few studies with large sample sizes 50 (CA50) were reported in BTC
e15129 Background: The implementation of adjuvant therapy in reducing tumor recurrence hepatocellular carcinoma (HCC) is an essential approach for extending the prognosis patients. exploration treatment strategies that are both efficacious and secure remains a prominent area research recent years. Donafenib novel, oral, small-molecule, multikinase inhibitor, has demonstrated promising efficacy safety profiles preclinical clinical studies. However, there currently lack reported data on...
Background: Adjuvant therapy is used to reduce the risk of hepatocellular carcinoma (HCC) recurrence and improve patient prognosis. Exploration treatment strategies that are both efficacious safe has been extensively performed in recent years. Although donafenib demonstrated good efficacy advanced HCC, its use as adjuvant HCC not reported. Objectives: To investigate safety postoperative patients with at high-risk recurrence. Design: Retrospective study. Methods: A total 196 were included...
Abstract Background Immune checkpoint inhibitors (ICIs) are playing a significant role in the treatment of hepatocellular carcinoma (HCC). This study aims to explore prognostic value alpha-fetoprotein (AFP) and initial tumor shape irregularity patients treated with ICIs. Methods In this retrospective, multi-center study, 296 HCC were randomly divided into training set validation 3:2 ratio. The was used evaluate factors develop an easily applicable ATSI (AFP Tumor Shape Irregularity) score,...
Objective: To compare the differences in prevalence of mild micro-hepatic encephalopathy (MHE) among patients with cirrhosis by using psychometric hepatic score (PHES) and Stroop smartphone application (Encephal App) test. Methods: This prospective, multi-center, real-world study was initiated National Clinical Medical Research Center for Infectious Diseases Portal Hypertension Alliance registered International ClinicalTrials.gov (NCT05140837). 354 cases were enrolled 19 hospitals across...
Aim: To explore the clinical significance of Cystathionine beta-synthase (CBS) expression in gastric cancer (GC).Research design and methods: CBS clinicopathological/follow-up information patients with undergoing operation were collected from The Cancer Genome Atlas (TCGA) database. association patients' overall survival (OS) was determined entire cohort different subgroups. Validation performed two external cohorts NCBI Gene Expression Omnibus (GEO) estimated drug response tumors...
Abstract BackgroundDysregulation of RNA binding protein (RBP) expression has been reported in various malignant tumors, and it is related to the occurrence development cancer. However, role RBPs colon cancer remains unclear.MethodsWe downloaded sequencing data from The Cancer Genome Atlas (TCGA) database, determined differently expressed between normal tissues. Then, through a series bioinformatics analysis, we systematically studied prognostic value these RBPs.ResultA total 490 different...