A5061765343- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Bone health and osteoporosis research
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Cancer-related molecular mechanisms research
- Bone fractures and treatments
- Bone health and treatments
- Hip and Femur Fractures
- Colorectal Cancer Screening and Detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Research and Splicing
- Inflammatory Biomarkers in Disease Prognosis
- Ubiquitin and proteasome pathways
- Bone Metabolism and Diseases
- Cancer-related gene regulation
- Minerals Flotation and Separation Techniques
- Angiogenesis and VEGF in Cancer
- Ferroptosis and cancer prognosis
- Ultrasound and Hyperthermia Applications
- AI in cancer detection
- Ultrasound in Clinical Applications
- interferon and immune responses
- Spinal Fractures and Fixation Techniques
- Mine drainage and remediation techniques
Harbin Medical University
2018-2025
Third Affiliated Hospital of Harbin Medical University
2020-2025
Changchun University of Chinese Medicine
2025
Shanghai Cancer Institute
2025
Renji Hospital
2025
Shanghai Jiao Tong University
2025
National Computer Network Emergency Response Technical Team/Coordination Center of Chinar
2024
First Affiliated Hospital of Harbin Medical University
2018-2019
Chinese PLA General Hospital
2016-2018
Chung Shan Medical University
2007
Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast...
Gastric cancer (GC) represents a significant burden of cancer-related mortality worldwide, underscoring an urgent need for the development early detection strategies and precise postoperative interventions. However, identification non-invasive biomarkers diagnosis patient risk stratification remains underexplored. Here, we conduct targeted metabolomics analysis 702 plasma samples from multi-center participants to elucidate GC metabolic reprogramming. Our machine learning reveals...
Solid tumour tissues are composed of and non-tumour cells, such as stromal cells immune cells. These constitute an essential part the microenvironment (TME), which decrease purity play important role in carcinogenesis, malignancy progression, treatment resistance prognostic assessment. However, implications various levels gastric cancer (GC) remain largely unknown. In present study, we used in-silico approach to infer 2,259 GC samples obtained from our hospital 12 public datasets based on...
Abstract Background Ovarian cancer poses a serious threat to women's health. Due the difficulty of early detection, most patients are diagnosed with advanced-stage disease or peritoneal metastasis. We found that LncRNA MEG3 is novel tumor suppressor, but its role in occurrence and development still unclear. Methods investigated expression level pan-cancer through bioinformatics analysis, especially gynecological tumors. Function assays were used detect effect on malignant phenotype ovarian...
Gastric cancer (GC) is the third leading cause of death worldwide. Its clinical course varies considerably due to highly heterogeneous tumour microenvironment (TME). Decomposing complex TME from histological images into its constituent parts crucial for evaluating patterns and enhancing GC therapies. Although various deep learning methods were developed in medical field, their applications on this task are hindered by lack well-annotated GC. Through work, we seek provide a large database...
298 Background: The current TNM staging system fails to provide adequate information for prognosis and adjuvant chemotherapy benefits in colorectal cancer (CRC). Pathomics, an emerging field, shows promise improving estimation decision-making. In this study, we developed validated a pathomics signature (PS CRC ) that directly analyzes hematoxylin eosin–stained slides using deep learning predict outcomes. Methods: A total of 883 whole slide images from two cohorts, Harbin Medical University...
This study aims to explore the mechanism of Huanglian Jiedu Decoction(HJD) in treating acute liver injury(ALI) mouse model sepsis induced by lipopolysaccharide(LPS). Fifty-four male C57BL/6 mice were randomized into six groups: blank group, low-, medium-, and high-dose group HJD, dexamethasone group. The was established intraperitoneal injection LPS after 7 days gavage with dexamethasone(0.2 mL) injected intraperitoneally 1.5 h modeling. murine score(MSS) recorded 12 levels alanine...
Colon cancer (CC) is a common malignancy with rising incidence worldwide. Despite advances in treatment strategies, many patients still face poor prognosis due to the development of drug resistance. Long non-coding RNAs (lncRNAs) have emerged as important regulators various biological processes and been implicated progression. Among them, colorectal neoplasia differentially expressed (CRNDE) has drawn attention for its potential roles different cancers. However, specific functions CC remain...
HCC is one of the most prevalent and deadliest malignancies worldwide, with a poor prognosis. Altered histone modifications have been shown to play significant role in HCC. However, biological roles clinical relevance specific modifications, such as asymmetric dimethylation on arginine 3 H4 (H4R3me2a), remain poorly understood In this study, immunohistochemical staining was performed assess H4R3me2a modification 32 pairs tissues corresponding adjacent nontumor liver tissues. Cellular-level...
To evaluate the potential of phase-change materials (PCMs) in improving indoor thermal and airflow environment Trombe walls under solar energy limitations, a computational fluid dynamics (CFDs) model was employed this study to perform comparative simulations. Taking traditional (TWs) as control group PCM-Trombe (PCM-TWs) experimental group, simulation analysis carried out based on meteorological data from typical spring day Hangzhou 2024. The results indicate that application PCM...
RNA processing converts primary transcript into mature RNA. Altered drives tumor initiation and maintenance, may generate novel therapeutic opportunities. However, the role of factors in gastric cancer (GC) has not been clearly elucidated. This study presents a comprehensive analysis exploring clinical, molecular, immune, drug response features underlying GC. included 1079 GC cases from The Cancer Genome Atlas (TCGA, training set), our hospital cohort, two other external validation sets...
Hemoglobin/red cell distribution width (HR) and platelet/lymphocyte (PLR) ratios are considered effective prognostic markers in various cancers. We have proposed a new parameter: HR+PLR. The aim of this study is to explore the value HR+PLR scoring system patients with gastric cancer liver metastasis.This retrospectively analyzed clinical data 306 metastases admitted our hospital from 2007 2014. According size HR PLR value, we will divide into three groups, namely, HR+PLR: (1) 0 points: >...