The rapidly emerging field of nanotechnology has offered innovative discoveries in the medical, industrial, and consumer sectors. unique physicochemical electrical properties engineered nanoparticles (NP) make them highly desirable a variety applications. However, these novel NP are fraught with concerns for environmental occupational exposure. Changes structural can lead to changes biological activities including ROS generation, one most frequently reported NP-associated toxicities....

Abstract Tumor cells metabolize in distinct pathways compared with most normal tissue cells. The resulting tumor microenvironment would provide characteristic physiochemical conditions for selective modalities. Here we introduce a concept of sequential catalytic nanomedicine efficient therapy by designing and delivering biocompatible nanocatalysts into sites. Natural glucose oxidase (GOD, enzyme catalyst) ultrasmall Fe 3 O 4 nanoparticles (inorganic nanozyme, Fenton reaction have been...

Traditional photodynamic therapy (PDT) suffers from the critical issues of low tissue-penetrating depth light and potential phototoxicity, which are expected to be solved by developing new dynamic therapy-based therapeutic modalities such as sonodynamic (SDT). In this work, we report on design/fabrication a high-performance multifunctional nanoparticulate sonosensitizer for efficient in vivo magnetic resonance imaging (MRI)-guided SDT against cancer. The developed approach takes structural...

Initiating localized catalytic chemical reactions in tumor microenvironment (TME) can achieve appealing tumor-therapeutic efficacy concurrently with high specificity and desirable biosafety, which is mainly dependent on the performance of biomedical nanocatalysts. This report demonstrates that PEGylated single-atom Fe-containing nanocatalysts (PSAF NCs) could effectively trigger situ tumor-specific Fenton reaction to generate abundant toxic hydroxyl radicals (•OH) selectively under acidic...

The antitumor activity of disulfiram (DSF), a traditional US Food and Drug Administration-approved drug for the treatment "alcohol-dependence", is Cu2+-dependent, but intrinsic anfractuous biodistribution copper in human body toxicity induced by exogenous supply have severely hindered its vivo application. Herein, we report an situ Cu2+ chelation-enhanced DSF-based cancer chemotherapy technique, using tumor-specific "nontoxicity-to-toxicity" transition strategy based on hollow mesoporous...

Abstract Sustained tumor oxygenation is of critical importance during type‐II photodynamic therapy (PDT), which depends on the intratumoral oxygen level for generation reactive species. Herein, modification photosynthetic cyanobacteria with photosensitizer chlorin e6 (ce6) to form ce6‐integrated photosensitive cells, termed ceCyan, reported. Upon 660 nm laser irradiation, sustained O 2 evolution by and immediate singlet species ( 1 ) integrated could be almost simultaneously achieved using...

Abstract Bacterial infection caused by pathogenic bacteria has long been an intractable issue that threatens human health. Herein, the fact nanocatalysts with single iron atoms anchored in nitrogen‐doped amorphous carbon (SAF NCs) can effectively induce peroxidase‐like activities presence of H 2 O , generating abundant hydroxyl radicals for highly effective bacterial elimination (e.g., Escherichia coli and Staphylococcus aureus ), is reported. In combination intrinsic photothermal...

Understanding and exploring the functional modules (FMs) consisting of local atomic groups can promote development materials with performances. Oxygen-containing tetrahedral are popular in deep-ultraviolet (DUV) optical materials, but their weak anisotropy is adverse to birefringence. Here, fluorooxosulfate group proved as a new birefringence-enhanced FM for first time. The birefringence fluorooxosulfates be 4.8-15.5 times that sulfates same metal cations while maintaining DUV band gap....

Abstract Effective antitumor therapeutics with distinctive bactericidal and osteogenic properties are in high demand for comprehensive osteosarcoma treatment. Here, a “scaffold engineering” strategy that integrates highly active single‐atomic iron catalysts (FeSAC) into 3D printed bioactive glass (BG) scaffold is reported. Based on the atomically dispersed species within catalysts, engineered FeSAC displays prominent Fenton catalytic activity to generate toxic hydroxyl radicals (•OH)...

The antioxidant α-lipoic acid (LA) is a naturally occurring compound that has been shown to possess promising anticancer activity because of its ability preferentially induce apoptosis and inhibit proliferation cancer cells relative normal cells. However, the molecular mechanisms underlying apoptotic effect LA are not well understood. We report here induced reactive oxygen species (ROS) generation concomitant increase in human lung epithelial H460 Inhibition ROS by scavengers or...

Abstract Fas-mediated apoptosis plays an important role in normal tissue homeostasis, and disruption of this death pathway contributes to many human diseases. Induction via Fas activation has been associated with reactive oxygen species (ROS) generation down-regulation FLICE inhibitory protein (FLIP); however, the relationship between these two events their are unclear. We show herein that ROS required for FLIP induction by ligand (FasL) primary lung epithelial cells. mediate ubiquitination...

Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack experimental models. Here, we show that chronic exposure single-walled causes malignant transformation human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic cancer This study provides new evidence for nanotube-induced carcinogenesis indicates potential role p53 process.

Accumulating evidence indicate that the degree of dispersion nanoparticles has a strong influence on their biological activities. The aims this study were to develop simple and rapid method nanoparticle using natural lung surfactant evaluate effect status SWCNT cytotoxicity fibrogenicity in vitro vivo.The Survanta® was used disperse single-walled carbon nanotubes (SWCNT) medium. At physiologically relevant concentrations, produced well dispersed without causing cytotoxic or fibrogenic...

Abstract As colorectal cancer is the fourth leading cause of cancer‐related death worldwide, therapy requires new strategies for improved therapeutic effects. Recently, nanodrug carriers have emerged to weaken systemic toxicity chemotherapy drugs and strengthen treatment effectiveness against cancer. In this report, ferulic acid, a plant derivative, polycondensed into poly(ferulic acid) (PFA) first time serve as an excellent drug carrier with anticancer performance. PFA self‐assembles...

Abstract In molecular self‐assembly molecules form organized structures or patterns. The control of the process is an important and challenging topic. Inspired by cytoskeletal‐membrane protein lipid bilayer system that determines shape eukaryotic cells, we developed a frame‐guided assembly as general strategy to prepare heterovesicles with programmed geometry dimensions. This method offers greater over which may benefit understanding formation mechanism well functions cell membrane.

The present work describes the systematic development of paclitaxel and naringenin-loaded solid lipid nanoparticles (SLNs) for treatment glioblastoma multiforme (GBM). So far only temozolomide therapy is available GBM treatment, which fails by large amount due to poor brain permeability drug recurrent metastasis tumor. Thus, we investigated combination containing naringenin GBM, as these drugs have individually demonstrated significant potential management a wide variety carcinoma. A product...

Abstract As a great drug, aspirin has been used to treat many important diseases. To expand the biomedical applications of material family, in this report, authors polymerized salicylic acid (functional part aspirin) into poly (salicylic acid) (PSA), which was once by‐product during synthesis. PSA can be formulated sub‐100 nm prickly nanoparticles (NPs) via nanoprecipitation self‐assembly procedure. The NPs are found nontoxic normal cells and cancer cells, but inhibit tumor growth CT26 mouse...

Abstract The hypoxic hallmark of tumor has aroused substantial burdens on a variety therapeutic modalities including photodynamic therapy (PDT). Recently, biological oxygen evolution enabled by photosynthetic cyanobacterial cells emerged as one the most advanced and promising tissue oxygenation strategies, which is particularly beneficial for in situ tumor‐PDT. Herein, near infrared‐driven PDT platform based hybridized with photosensitizer rose bengal (RB)‐loaded upconversion nanoparticles,...