A5047844264- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Lipid Membrane Structure and Behavior
- Surfactants and Colloidal Systems
- X-ray Diffraction in Crystallography
- Wind and Air Flow Studies
- Chemical Synthesis and Analysis
- Crystallization and Solubility Studies
- Polydiacetylene-based materials and applications
- Molecular Sensors and Ion Detection
- Synthesis and Biological Evaluation
- Nanomaterials for catalytic reactions
- Porphyrin and Phthalocyanine Chemistry
- Nanocluster Synthesis and Applications
- Synthesis of heterocyclic compounds
- Asymmetric Hydrogenation and Catalysis
- Hydrogels: synthesis, properties, applications
- Synthesis and Characterization of Heterocyclic Compounds
- Multicomponent Synthesis of Heterocycles
- Fluid Dynamics and Mixing
- Genetic Mapping and Diversity in Plants and Animals
- Synthesis and biological activity
- Aerodynamics and Fluid Dynamics Research
Shandong Provincial Hospital
2021-2025
Shandong First Medical University
2021-2025
China North Industries Group Corporation (China)
2025
Tianjin University of Technology
2014-2024
China University of Petroleum, East China
2014-2023
Shandong Normal University
2022
Corning (United States)
1997-2020
Hunan Normal University
2019
Henan University of Science and Technology
2019
China University of Petroleum, Beijing
2018
Y switch? A fast, pH-responsive DNA hydrogel (see picture; right) was prepared by a three-armed nanostructure (left) assembling together through the formation of intermolecular i-motif structures (middle). The can be switched to non-gel state in minutes simply using environmental pH changes. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note:...
Global climate change has a significant effect on extreme environments and profound influence species survival. However, little is known of the genome-wide pattern livestock adaptations to over short time frame following domestication. Sheep (Ovis aries) have become well adapted diverse range agroecological zones, including certain (e.g., plateaus deserts), during their post-domestication (approximately 8–9 kya) migration differentiation. Here, we generated whole-genome sequences from 77...
Wer schaltet am schnellsten? Ein schnelles, pH-responsives DNA-Hydrogel (rechts im Bild) wurde ausgehend von einer dreiarmigen DNA-Nanostruktur (links) unter Bildung intermolekularen i-Strukturen (Mitte) erhalten. Eine Änderung des pH-Werts der Umgebung genügt, damit das Hydrogel binnen Minuten in den ungelierten Zustand wechselt. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They...
Abstract Peptide self-assembly is a hierarchical process, often starting with the formation of α-helices, β-sheets or β-hairpins. However, how secondary structures undergo further assembly to form higher-order architectures remains largely unexplored. The polar zipper originally proposed by Perutz formed between neighboring β-strands poly-glutamine via their side-chain hydrogen bonding and helps stabilize sheet. By rational design short amphiphilic peptides self-assembly, here we demonstrate...
Abstract In molecular self‐assembly molecules form organized structures or patterns. The control of the process is an important and challenging topic. Inspired by cytoskeletal‐membrane protein lipid bilayer system that determines shape eukaryotic cells, we developed a frame‐guided assembly as general strategy to prepare heterovesicles with programmed geometry dimensions. This method offers greater over which may benefit understanding formation mechanism well functions cell membrane.
The combination of the readily available chiral bisphosphine ligand Difluorphos with [Ir(COD)Cl]2 in THF resulted a highly efficient catalyst system for asymmetric hydrogenation quinolines at quite low loadings (0.05–0.002 mol%), affording corresponding products high enantioselectivities (up to 96%), excellent catalytic activities (TOF up 3510 h−1) and productivities (TON 43000). same was also successfully applied trisubstituted pyridines nearly quantitative yields 98% ee. In these two...
Porous liquids are porous materials that have exhibited unique properties in various fields. Herein, we developed a method to synthesize the type I via liquefaction of cyclodextrins by chemical modification. The cyclodextrin were characterized Fourier-transform infrared (FTIR) spectroscopy, NMR, matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS), circular dichroism (CD), and UV–vis spectroscopy. measured ionic conductivity γ-cyclodextrin liquid was...
Abstract DNA hydrogels have attracted increasing attention owing to their excellent permeability and high mechanical strength, together with thixotropy, versatile programmability good biocompatibility. However, the moderate biostability immune stimulation of arisen as big concerns for future potential clinical applications. Herein, we report self‐assembly a novel l ‐DNA hydrogel, which inherited extraordinary physical properties d hydrogel. With mirror‐isomer deoxyribose, this hydrogel...
Osteoarthritis (OA) is characterized by progressive and irreversible damage to the articular cartilage a consecutive inflammatory response. However, majority of clinical drugs for OA treatment only alleviate symptoms without addressing fundamental pathology. To mitigate this issue, we developed an inflammation-responsive carrier encapsulated bioactive material, namely, LDH@TAGel. The LDH@TAGel was designed with anti-inflammatory antioxidative abilities, aiming directly address pathology...
Highly fluorescent carbon dots (CDs) with quantum yields up to 96% were rapidly synthesized within 5 min via microwave irradiation controllable temperature. Multifunctional bioimaging including live cell staining, cell-specific targeting and in vivo imaging further demonstrated by using high quality low cost CDs as contrast agents.
Developing eco-friendly, high-performance adhesives is crucial for sustainable industrial applications but remains a significant challenge. Herein, synergistic strategy combining core-shell hybridization and borate chemistry was employed to fabricate multifunctional soy protein (SPI) adhesive with excellent adhesion. Specifically, reactive hybrid (POSS-U) synthesized via free-radical polymerization using octavinyl-POSS as the core urushiol (U) shell. Sodium (SB) then added crosslinker, along...
A new kind of amphiphilic DNA-dendron hybrid consisting a highly hydrophobic dendron and single stranded DNA is synthesized. The could assemble into long nanofibers in aqueous phase. hybridization property at the shell fibers associated with encapsulation ability inner core enable further functionalization, offering unique class supramolecular building block.
We report a new strategy to prepare DNA mono-modified gold nanoparticles (AuNPs). By adding short rigid duplex proximal the AuNPs, assembly efficiency of AuNPs with Y-shaped could be improved nearly 6-fold.
To improve the stability of foam fluids, SiO2 nanoparticles and trace amount Gemini cationic surfactant were combined with main foaming agent, nonionic surfactant, to form a tricomponent multiphase foam. The was assessed through two parameters half-life time dilational modulus. interaction between surfactants studied though surface tension, adsorption amount, ζ potential measurement. effects saline ions temperature on also investigated. plugging ability using sandpack model. optimized 10...
Fluorescence imaging requires bioselective, sensitive, nontoxic molecular probes to detect the precise location of lesions for fundamental research and clinical applications. Typical inorganic semiconductor nanomaterials with large sizes (>10 nm) can offer high-quality fluorescence due their fascinating optical properties but are limited low selectivity as well slow clearance pathway. We here report an N- O-rich carbogenic small complex (SMC, MW < 1000 Da) that exhibits high quantum yield...
This study was conducted to analyze the clinical characteristics of and treatment strategies for botulism among patients receiving cosmetic injection botulinum toxin (BoNT). A total 86 caused by BoNT were enrolled in our study. All diagnosed according their history injection, symptoms signs, other auxiliary examinations (including those on renal liver functions, blood index detection, chest X-ray). received comprehensive treatments antitoxin serum injection. The main included headache,...
The nucleolus is an important subnuclear structure and there are very few dyes available in the market for nucleolar imaging. Subcellular organelles delivery presents a common stumbling block many nanomaterial-based applications, including intracellular fluorescence staining. We now introduce novel luminescent graphene quantum dot (nGQD), which able to selectively light up nucleoli of living cells, address these challenges. Investigations on subcellular localization different GQDs have...
In human pathological conditions, the acidification of local environment is a frequent feature, such as tumor and inflammation. As pH microenvironment alters, functions immune cells are about to change. It makes extracellular key modulator innate immunity. Here we detected impact on neutrophil apoptosis functions, including cell death, respiratory burst, migration phagocytosis. result, found that under acid environment, delayed, burst inhibited, polarization augmented, chemotaxis differed,...