A5100423347- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Urological Disorders and Treatments
- Selenium in Biological Systems
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- MicroRNA in disease regulation
- DNA and Nucleic Acid Chemistry
- Ruminant Nutrition and Digestive Physiology
- Computational Drug Discovery Methods
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Soil Carbon and Nitrogen Dynamics
- Renal and Vascular Pathologies
- Urinary and Genital Oncology Studies
- Urologic and reproductive health conditions
- Inflammasome and immune disorders
- Privacy-Preserving Technologies in Data
- Radiation Therapy and Dosimetry
- Cerebrospinal fluid and hydrocephalus
- Evaluation and Optimization Models
- Soil and Unsaturated Flow
- Per- and polyfluoroalkyl substances research
- Moringa oleifera research and applications
- Pediatric Urology and Nephrology Studies
Children's Hospital of Zhejiang University
2025
East China University of Science and Technology
2025
China International Science and Technology Cooperation
2022-2024
Children's Hospital of Chongqing Medical University
2022-2024
Chongqing Medical University
2022-2024
Zhengzhou University
2023-2024
Northwest A&F University
2023-2024
Northeast Agricultural University
2024
Tianjin University
2023
National Clinical Research
2023
Abstract Postoperative tumor recurrence and metastases often lead to cancer treatment failure. Here, we develop a local embedded photodynamic immunomodulatory DNA hydrogel for early warning inhibition of postoperative recurrence. The contains PDL1 aptamers that capture enrich in situ relapsed cells, increasing ATP concentration provide timely signal. When positive signal is detected, laser irradiation performed trigger therapy kill captured cells release tumor-associated antigens (TAA). In...
Multidrug resistance (MDR) is a major cause of chemotherapy failure in oncology, and gene therapy an excellent measure to reverse MDR. However, conventional only modulates the expression MDR-associated proteins but hardly affects their existing function, thus limiting efficiency tumor treatment. Herein, we designed photoactivated DNA nanodrug (MCD@TMPyP4@DOX) improve chemosensitivity through downregulation MDR-related genes mitochondria-targeted photodynamic (PDT). The self-assembled encodes...
Abstract DNA hydrogels have attracted increasing attention owing to their excellent permeability and high mechanical strength, together with thixotropy, versatile programmability good biocompatibility. However, the moderate biostability immune stimulation of arisen as big concerns for future potential clinical applications. Herein, we report self‐assembly a novel l ‐DNA hydrogel, which inherited extraordinary physical properties d hydrogel. With mirror‐isomer deoxyribose, this hydrogel...
Renal ischemia reperfusion injuries (IRIs) are very common in clinical diagnoses and treatments, which a cause of impaired renal functions, worsening pathological damage, affecting disease progression hindering recovery. IRIs an inflammatory mediated by the adaptive innate immune system. There is complex interaction between oxidative stress cell infiltration. Therefore, we aimed to determine biomarkers associated with during their relationship infiltration.A differential gene expression...
The clinical phenotypes of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) have been found to overlap with several other diseases. new criteria proposed in 2023 were designed better identify the but require validation across various populations ascertain its utility. We aimed investigate diagnostic performance phenotypically diverse patients. This multicenter study retrospectively included adult and pediatric patients who hospitalized for a first suspected...
Abstract DNA hydrogels have attracted increasing attention owing to their excellent permeability and high mechanical strength, together with thixotropy, versatile programmability good biocompatibility. However, the moderate biostability immune stimulation of arisen as big concerns for future potential clinical applications. Herein, we report self‐assembly a novel l ‐DNA hydrogel, which inherited extraordinary physical properties d hydrogel. With mirror‐isomer deoxyribose, this hydrogel...
Despite the popularity and ubiquity of tilted-pulse-front technique for single-cycle terahertz (THz) pulse generation, there is a deficit experimental studies comprehensively mapping out dependence performance on key setup parameters. The most critical parameters include pulse-front tilt, effective length pump propagation within crystal as well over which THz beam interacts with before it spatially walks off. Therefore, we investigate impact these conversion efficiency shape via...
Personal data collected by wearable devices contains rich privacy. It is important to realize the personal privacy protection for user without affecting collection of device services. In order protect users' privacy, a scheme based on local differential proposed single attribute numerical stream data. At first, points are censored identify salient points, and adaptive Laplacian mechanism used add noise these according assigned budget; then collector reconstructs fits curve noise-added so as...
Ischemia-reperfusion injury (IRI) is inevitable in kidney transplantations and, as a complex pathophysiological process, it can be greatly impacted by ferroptosis and immune inflammation. Our study aimed to identify the biomarkers of renal IRI (RIRI) elucidate their relationship with infiltration. In this study, GSE148420 database was used training set analyze differential genes overlap them ferroptosis-related hub using protein–protein interaction (PPI) network, least absolute shrinkage...
The long-term cultivation of apple trees with deep root systems can significantly deplete moisture from the soil layers, while extreme rainfall events rapidly replenish this moisture. Therefore, it is great academic significance to investigate influence precipitation on water dynamics in orchards varying ages. This study was conducted agricultural land and 12 years, 15 19 years 22 (12 y, y y) examine impact transport. Soil content hydrogen oxygen isotope (2H, 18O 3H) data were collected...
Renal ischemia-reperfusion injuries (IRIs) are one of the leading causes acute kidney (AKIs). Selenium, as an essential trace element, is able to antioxidant stress and reduces inflammatory responses. The regulation mechanism selenomethionine, major forms selenium intake by humans, not yet clear in renal IRIs. Therefore, we aimed explore key targets related mechanisms selenomethionine IRIs provide new ideas for treatment with We used transcriptome sequencing data from public databases well...
Despite the continuous development and evolution of surgical methods techniques, proximal hypospadias remains one most challenging issues for pediatric urologists. This study aims to evaluate indications postoperative complications our new modified Duckett urethroplasty.A total 133 patients with who underwent repair urethroplasty from February 2016 2021 were reviewed. The median age was 3 years (range 1-16). All had severe chordee. One senior experienced urologist performed all surgeries....