A5074143182- Advanced biosensing and bioanalysis techniques
- Molecular Junctions and Nanostructures
- Fullerene Chemistry and Applications
- RNA Interference and Gene Delivery
- Nanofabrication and Lithography Techniques
- Quantum Dots Synthesis And Properties
- Force Microscopy Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Microfluidic and Bio-sensing Technologies
- Biosensors and Analytical Detection
- Glycosylation and Glycoproteins Research
- Nanocluster Synthesis and Applications
- Graphene research and applications
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Microfluidic and Capillary Electrophoresis Applications
- Lanthanide and Transition Metal Complexes
- Gold and Silver Nanoparticles Synthesis and Applications
- Spectroscopy and Quantum Chemical Studies
- DNA and Nucleic Acid Chemistry
- Nonlinear Optical Materials Research
- Advanced Nanomaterials in Catalysis
- Porphyrin and Phthalocyanine Chemistry
- Nanoplatforms for cancer theranostics
- Photochemistry and Electron Transfer Studies
Fudan University
2025
University of Leeds
2015-2024
University of Göttingen
2022
Institute of Structural and Molecular Biology
2008-2019
Guilin University of Electronic Technology
2007-2019
Guangxi University of Science and Technology
2008-2019
Xidian University
2009-2019
Guilin University
2007-2018
Wuhan University
2015-2018
Renmin Hospital of Wuhan University
2018
Y switch? A fast, pH-responsive DNA hydrogel (see picture; right) was prepared by a three-armed nanostructure (left) assembling together through the formation of intermolecular i-motif structures (middle). The can be switched to non-gel state in minutes simply using environmental pH changes. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note:...
An array of surface-immobilized proton-fueled DNA nanomachines is reversibly actuated by cycling the solution pH between 4.5 and 9, producing a conformational change four-stranded double-stranded structure, which elongates or shortens separation distance 5' 3' end DNA. By labeling with fluorophore immobilizing it onto thin-gold surface through its thiol modification, nanoscale motion produces mechanical work to lift up bring down from gold at least 2.5 nm transduces this into an optical...
Ultra-small gold nanoclusters (AuNCs) have unique size-dependent optical, electrical and chemical properties. They emerged as a new nanomaterial with broad applications in optoelectronics, catalysis, biosensing, bioimaging. Several strategies been exploited to prepare AuNCs of different "magic number" sizes, using templates e.g. dendrimers, polyethyleneimines, peptides, more recently, proteins. Notwithstanding, almost all bio-template-protected reported so far exhibit fairly low fluorescence...
Ribonuclease-A (RNase-A) encapsulated PbS quantum dots (RNase-A@PbS Qdots) which emit in the second near-infrared biological window (NIR-II, ca. 1000–1400 nm) are rapidly synthesized under microwave heating. Photoluminescence (PL) spectra of Qdots can be tuned across entire NIR-II range by simply controlling synthesis temperature. The size and morphology examined transmission electron microscopy (TEM), atomic force (AFM), dynamic light scattering (DLS). Quantum yield (Φf) measurement...
A novel drug nanocarrier that offers simple, direct, native form loading without involving any chemical modification and/or coupling step has been developed by using a pH-responsive DNA–gold nanoparticle conjugate. It can resist non-specific adsorption of serum proteins upon PEGylation and provide efficient delivery pH-triggered release anticancer drugs to cancer cells, leading high cytotoxicity. As service our authors readers, this journal provides supporting information supplied the...
Multivalent lectin-glycan interactions are widespread in biology and often exploited by pathogens to bind infect host cells. Glycoconjugates can block such thereby prevent infection. The inhibition potency strongly depends on matching the spatial arrangement between multivalent binding partners. However, structural details of some key lectins remain unknown different may exhibit overlapping glycan specificity. This makes it difficult design a glycoconjugate that potently specifically target...
Developing effective lymph-node (LN) targeting and imaging probes is crucial for the early detection diagnosis of tumor metastasis to improve patient survival. Most current clinical LN are based on small organic dyes (e.g., indocyanine green) or radioactive 99mTc-complexes, which often suffer from limitations, such as rapid photobleaching, poor signal contrast, potential biosafety issues. Moreover, these cannot easily incorporate therapeutic functions realize beneficial theranostics without...
Bacterial keratitis is a serious ocular disease that affects millions of people worldwide each year, among which ≈25% are caused by Staphylococcus aureus. With the spread bacterial resistance, refractory methicillin-resistant S. aureus (MRSA) ≈120 000-190 000 annually and significant cause infectious blindness. Atomically precise gold nanoclusters (GNCs) recently emerged as promising antibacterial agents; although how GNC structure capping ligands control properties remains largely...
We present a new, general method for the controlled deposition of biological molecules on surfaces, based nanopipet operating in ionic solution. The potential applied to pipet tip controls flux from pipet, allowing fine control delivery rate. used ion current distance surface glass slide and deposited fluorescently labeled DNA or protein G at defined location onto surface. Features 830 nm size were obtained by depositing biotinylated streptavidin surface; 1.3 μm spots positively charged
We show that direct coupling of a dye-labelled DNA (acceptor) to quantum dot (QD) donor significantly reduces the donor–acceptor distance and improves FRET efficiency: highly efficient (∼88%) at low acceptor-to-donor ratio 2 has been achieved single-molecule level.
In this letter, we report the preparation of a compact, functional quantum dot (QD)−DNA conjugate, where capturing target DNA is directly and covalently coupled to QD surface. This enables control separation distance between donor dye acceptor within range Förster radius. Moreover, tri(ethylene glycol) linker introduced surface coating effectively eliminate strong, nonspecific adsorption on As result, QD−DNA conjugate hybridizes specifically its complementary with hybridization rate constant...
Wer schaltet am schnellsten? Ein schnelles, pH-responsives DNA-Hydrogel (rechts im Bild) wurde ausgehend von einer dreiarmigen DNA-Nanostruktur (links) unter Bildung intermolekularen i-Strukturen (Mitte) erhalten. Eine Änderung des pH-Werts der Umgebung genügt, damit das Hydrogel binnen Minuten in den ungelierten Zustand wechselt. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They...
Amino acid esters react with C60 both thermally and photochemically to give different products. Refluxing a mixture of glycine ethyl ester afforded C60(Me2CHNHCHCOOEt) 1, whereas irradiation the same produced C60(EtOOCCHNHCHCOOEt) 2b as main product. Photochemical reactions between sarcosine yielded two pyrrolidine derivatives C60(CH2N(Me)CHCOOR) 3 C60(ROOCCHNHCHCOOR) 2 (R = Me, Et, CH2Ph). Compound 2a is also prepared from photochemical reaction iminodiacetic methyl in high yield. These are...
Caught in a trap and on camera: A nanopipette is used for electrodeless dielectrophoresis clear evidence shown, by using wide-field fluorescence imaging (see image), the reversible trapping of Alexa-488-labeled proteins (protein G immunoglobulin G) also fluorophore alone. The dielectrophoretic concentration enhanced at least factor 300 these fluorophore-labeled proteins. Supporting Information this article available WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z500196_s.html or...
Herein we report the development of a highly active, magnetically retrievable and reusable biocatalyst using multilayer enzyme coupled-magnetic nanoparticles (MNPs) prepared by layer-by-layer assembly two well-studied enzymes, horseradish peroxidase (HRP) glucose oxidase (GOX), as model system. We show that combining use biocompatible linker well biospecific immobilisation, first layer in our HRP1–MNP system retains native activity solution, overall catalytic system, HRPx–MNP, increases...
We have used systematic evolution of ligands by exponential enrichment (SELEX) to isolate RNA aptamers against aminoglycoside antibiotics. The SELEX rounds were toggled four pairs aminoglycosides with the goal isolating reagents that recognize conserved structural features. resulting bind both their selection targets nanomolar affinities. They also less structurally related targets, although they show clear specificity for this class lack is a common property previously selected single...
A multifunctional anti-cancer nanomedicine based on a biotin-poly(ethylene glycol)-poly(curcumin-dithio dipropionic acid) (Biotin-PEG-PCDA) polymeric nanocarrier loaded with paclitaxel (PTX), magnetic nanoparticles (MNPs) and quantum dots (QDs) is developed. It combines advantageous properties of efficient targeted delivery uptake (
Multivalent protein–carbohydrate interactions initiate the first contacts between virus/bacteria and target cells, which ultimately lead to infection. Understanding structures binding modes involved is vital design of specific, potent multivalent inhibitors. However, lack structural information on such flexible, complex, multimeric cell surface membrane proteins has often hampered endeavors. Herein, we report that quantum dots (QDs) displayed with a dense array mono-/disaccharides are...
A highly efficient cap-exchange approach for preparing compact, dense polyvalent mannose-capped quantum dots (QDs) has been developed. The resulting QDs have successfully used to probe multivalent interactions of HIV/Ebola receptors DC-SIGN and DC-SIGNR (collectively termed as DC-SIGN/R) using a sensitive, ratiometric Förster resonance energy transfer (FRET) assay. QD probes specifically bind DC-SIGN, but not its closely related receptor DC-SIGNR, which is further confirmed by specific...