A5062726739- Alzheimer's disease research and treatments
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Angiogenesis and VEGF in Cancer
- Protein Tyrosine Phosphatases
- Regulation of Appetite and Obesity
- Diabetes Treatment and Management
- 14-3-3 protein interactions
- Protease and Inhibitor Mechanisms
- Erythrocyte Function and Pathophysiology
- Electrochemical sensors and biosensors
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Biological Research and Disease Studies
- Endoplasmic Reticulum Stress and Disease
- Blood properties and coagulation
- Blood Coagulation and Thrombosis Mechanisms
- Cell Adhesion Molecules Research
- Neurological Disorders and Treatments
University of Leeds
2011-2024
Self Regional Healthcare
1991
Greenwood Genetic Center
1991
Herein we report the development of a highly active, magnetically retrievable and reusable biocatalyst using multilayer enzyme coupled-magnetic nanoparticles (MNPs) prepared by layer-by-layer assembly two well-studied enzymes, horseradish peroxidase (HRP) glucose oxidase (GOX), as model system. We show that combining use biocompatible linker well biospecific immobilisation, first layer in our HRP1–MNP system retains native activity solution, overall catalytic system, HRPx–MNP, increases...
The β-site Amyloid precursor protein Cleaving Enzyme 1 (BACE1) is an extensively studied therapeutic target for Alzheimer's disease (AD), owing to its role in the production of neurotoxic amyloid beta (Aβ) peptides. However, despite numerous BACE1 inhibitors entering clinical trials, none have successfully improved AD pathogenesis, effectively lowering Aβ concentrations. This can, part, be attributed incomplete understanding BACE1, including physiological functions and substrate specificity....
Cardiac fibroblasts are pivotal regulators of cardiac homeostasis and essential in the repair heart after myocardial infarction (MI), but their function can also become dysregulated, leading to adverse remodelling involving both fibrosis hypertrophy. MicroRNAs (miRNAs) noncoding RNAs that target mRNAs prevent translation, with specific miRNAs showing differential expression regulation cardiovascular disease. Here, we show miR-214-3p is enriched fibroblast fraction murine heart, its levels...
DNA from a male fetus with an interstitial deletion of 7q22 [(46, XY, del(7)(pter→q22.10::q31.10→qter)] was analyzed using probes in this region 7q. The results localize plasminogen activator inhibitor type I (PLANHl) to 7q22.1→q22.3 and β-glucuronidase band 7q211.1
<h3></h3> Cardiovascular disease is a known risk factor for dementia, associating two of the most abundant age-associated diseases. Around 7.6 million people are living with heart and circulatory diseases within UK, presenting substantial number potentially modifiable dementia. Understanding molecular mechanisms acting upon cerebrovasculature could therefore provide therapeutic target vascular dementia have huge impact on public health. The beta secretase 1 (BACE1) enzyme clinically relevant...