Conventionally, ceramics-based materials, fabricated by high-temperature solid-phase reaction and sintering, are preferred as bone scaffolds in hard-tissue engineering because of their tunable biocompatibility mechanical properties. However, possible biomedical applications have rarely been considered, especially the cancer phototherapeutic both first second near-infrared light (NIR-I NIR-II) biowindows. In this work, we explore, for time far know, a novel kind 2D niobium carbide (Nb2C),...

Traditional photodynamic therapy (PDT) suffers from the critical issues of low tissue-penetrating depth light and potential phototoxicity, which are expected to be solved by developing new dynamic therapy-based therapeutic modalities such as sonodynamic (SDT). In this work, we report on design/fabrication a high-performance multifunctional nanoparticulate sonosensitizer for efficient in vivo magnetic resonance imaging (MRI)-guided SDT against cancer. The developed approach takes structural...

Abstract Emerging nanocatalytic tumor therapies based on nontoxic but catalytically active inorganic nanoparticles (NPs) for intratumoral production of high‐toxic reactive oxygen species have inspired great research interest in the scientific community. Nanozymes exhibiting natural enzyme‐mimicking catalytic activities been extensively explored biomedicine, mostly biomolecular detection, yet much fewer researches are available specific therapy. This study reports construction an efficient...

2D transition metal carbides or nitrides, known as MXenes, are a new family of materials with close to 30 members experimentally synthesized and dozens more theoretically investigated. Because the abundant surface terminations, MXenes have been compounded various by multi-interactions. In addition prevented aggregation oxidation MXene flakes, MXene/polymer membranes exhibit outstanding mechanical, thermal, electrical properties due synergistic effects. However, relatively little is currently...

The large-dimensional and rigid ceramic bulks fabricated by high-temperature solid-phase reaction sintering have never been considered for possibly entering circulating within the blood vessels biomedical applications, especially on combating cancer. Here, it is reported first time that MAX biomaterials exhibit unique functionalities dual-mode photoacoustic/computed tomography imaging are highly effective in vivo photothermal ablation of tumors upon being exfoliated into ultrathin nanosheets...

MXenes, an emerging family of graphene-analogues two-dimensional (2D) materials, have attracted continuous and tremendous attention in many application fields because their intrinsic physiochemical properties high performance versatile applications. In this work, we report on the construction tantalum carbide (Ta4C3) MXene-based composite nanosheets for multiple imaging-guided photothermal tumor ablation, which has been achieved by rational choice composition MXenes surface...

Abstract Two‐dimensional (2D) MXenes, as a new 2D functional material nanosystem, have been extensively explored for broad applications. However, their specific performance and applications in theranostic nanomedicine still rarely explored. This work reports on the drug‐delivery synergistic therapeutic efficiency of Ti 3 C 2 MXenes highly efficient tumor eradication. These not only possess high drug‐loading capability 211.8%, but also exhibit both pH‐responsive near infrared laser‐triggered...

The conventional inorganic semiconductors are not suitable for in vivo therapeutic nanomedicine because of the lack an adequate and safe irradiation source to activate them. This work reports on rational design titania (TiO2)-based enhanced synergistic sono-/photoinduced tumor eradication by creating oxygen-deficient TiO2–x layer onto surface TiO2 nanocrystals, which can create a crystalline-disordered core/shell structure (TiO2@TiO2–x) with black color. As found lessons from traditional...

The emerging of two-dimensional (2D) MXenes significantly broadens the family members and versatile applications 2D materials, but rational design MXene-based composites their specific in theranostic biomedicine are still challenging. In this work, we report, for first time, on elaborate Ti3C2-based composite MXene (MnOx/Ti3C2) highly efficient against cancer. These MnOx/Ti3C2 have been constructed by triggering a simple redox reaction to situ grow small MnOx nanosheets surface Ti3C2....

Abstract The oxidation of intracellular biomolecules by reactive oxygen species (ROS) forms the basis for ROS‐based tumor therapy. However, current therapeutic modalities cannot catalyze H 2 O and concurrently ROS generation, thereby leading to unsatisfactory efficacy. Herein, it is reported a bioinspired hollow N‐doped carbon sphere doped with single‐atom copper (Cu‐HNCS) that can directly decomposition both hydrogen peroxide ROS, namely superoxide ion (O • − ) hydroxyl radical (•OH),...

The antitumor activity of disulfiram (DSF), a traditional US Food and Drug Administration-approved drug for the treatment "alcohol-dependence", is Cu2+-dependent, but intrinsic anfractuous biodistribution copper in human body toxicity induced by exogenous supply have severely hindered its vivo application. Herein, we report an situ Cu2+ chelation-enhanced DSF-based cancer chemotherapy technique, using tumor-specific "nontoxicity-to-toxicity" transition strategy based on hollow mesoporous...

Abstract Hepatocellular carcinoma (HCC) is one of the most common and deadly gastrointestinal malignancies. Given its insensitivity to traditional systematic chemotherapy, new therapeutic strategies for efficient HCCs treatment are urgently needed. Here, development a novel 2D MXene‐based composite nanoplatform highly synergistic chemotherapy photothermal hyperthermia against HCC reported. A surface‐nanopore engineering strategy developed MXenes’ surface functionalization, which achieves...

: The emergence of two-dimensional MXenes has spurred their versatile applications in broad fields, but the exploring novel MXene-based family members and potential theranostic nanomedicine (concurrent diagnostic imaging therapy) have been rarely explored. In this work, we report construction a superparamagnetic nanoplatform for efficient breast-cancer theranostics, which was based on intriguing tantalum carbide (Ta

Ionizing radiation (IR) has been extensively used in industry and radiotherapy, but IR exposure from nuclear or radiological accidents often causes serious health effects an exposed individual, its application radiotherapy inevitably brings undesirable damage to normal tissues. In this work, we have developed ultrathin two-dimensional (2D) niobium carbide (Nb2C) MXene as a radioprotectant explored scavenging free radicals against IR. The 2D Nb2C features intriguing antioxidant properties...

Ferroptosis, an emerging type of cell death found in the past decades, features specifically lipid peroxidation during process commonly by iron accumulation. Unfortunately, however, direct delivery species may trigger undesired detrimental effects such as anaphylactic reactions normal tissues. Up to date, reports on cellular ferroptosis using nonferrous metal elements can be rarely found. In this work, we propose a ferroptosis-like strategy based hybrid CoMoO4-phosphomolybdic acid nanosheet...

Abstract Damaged skin cannot prevent harmful bacteria from invading tissues, causing infected wounds and even serious tissue damage. Traditional treatments can not only kill pathogenic bacteria, but also suppress the growth of beneficial thus destroying balance damaged microbial ecosystem. Here, a living bacterial hydrogel scaffold is reported that accelerates wound healing through secreting antibacterial substances. Lactobacillus reuteri , common probiotic, encapsulated in microspheres by...

Two-dimensional (2D) MXenes have emerged as a promising planar theranostic nanoplatform for versatile biomedical applications; but their in vivo behavior and performance has been severely influenced hindered by lack of necessary surface chemistry adequate engineering. To solve this critical issue, work employs sol-gel the construction unique "therapeutic mesopore" layer onto 2D niobium carbide (Nb2C) MXene. Methods: The situ self-assembled mesopore-making agent (cetanecyltrimethylammonium...

Incurable bacterial infections, impenetrable microbial biofilm, and irreversible antibiotic resistance are among the most dangerous threats for humans. With few effective strategies available in antimicrobial antibiofilm development, innovative methodologies inspired by advances other fields such as nanomedicine becoming more attractive to realize antibacterial agents. Herein, a 2D niobium carbide (Nb2C) MXene titanium plate (Nb2C@TP)-based clinical implant with practical multimodal...

Abstract Phototherapy has emerged as a novel therapeutic modality for cancer treatment, but its low efficacy severely hinders further extensive clinical translation and application. This study reports amplifying the phototherapeutic by constructing near‐infrared (NIR)‐responsive multifunctional nanoplatform synergistic phototherapy single NIR irradiation, which can concurrently achieve mitochondria‐targeting phototherapy, photothermal therapy (PTT)/photodynamic (PDT), self‐sufficient...