A5100359496- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Paraquat toxicity studies and treatments
- Peroxisome Proliferator-Activated Receptors
- Esophageal Cancer Research and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA modifications and cancer
- Gut microbiota and health
- Metabolism, Diabetes, and Cancer
- Methemoglobinemia and Tumor Lysis Syndrome
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Reconstructive Surgery and Microvascular Techniques
- Gastric Cancer Management and Outcomes
- Eosinophilic Disorders and Syndromes
- Anesthesia and Pain Management
- Heme Oxygenase-1 and Carbon Monoxide
- Head and Neck Cancer Studies
- Hepatitis C virus research
- Poisoning and overdose treatments
- Advanced biosensing and bioanalysis techniques
- Hepatitis B Virus Studies
- Pancreatic function and diabetes
- Animal Virus Infections Studies
- Cancer Genomics and Diagnostics
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2022-2024
Nankai University
2024
China Medical University
2012-2024
Shanghai University of Traditional Chinese Medicine
2022-2024
Soochow University
2024
National Cancer Institute
2023
National Institutes of Health
2023
Anhui Provincial Hospital
2016-2023
University of Science and Technology of China
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Objective The lack of highly sensitive and specific diagnostic biomarkers is a major contributor to the poor outcomes patients with hepatocellular carcinoma (HCC). We sought develop non-invasive approach using circulating cell-free DNA (cfDNA) for early detection HCC. Design Applying 5hmC-Seal technique, we obtained genome-wide 5-hydroxymethylcytosines (5hmC) in cfDNA samples from 2554 Chinese subjects: 1204 HCC, 392 chronic hepatitis B virus infection (CHB) or liver cirrhosis (LC) 958...
Abstract Damaged skin cannot prevent harmful bacteria from invading tissues, causing infected wounds and even serious tissue damage. Traditional treatments can not only kill pathogenic bacteria, but also suppress the growth of beneficial thus destroying balance damaged microbial ecosystem. Here, a living bacterial hydrogel scaffold is reported that accelerates wound healing through secreting antibacterial substances. Lactobacillus reuteri , common probiotic, encapsulated in microspheres by...
N6-methyladenosine (m6A) has been reported as an important mechanism of posttranscriptional regulation. Programmed death-ligand 1 (PD-L1) is a primary immune inhibitory molecule expressed on tumor cells that promotes evasion. Here we report ALKBH5 m6A demethylase orchestrates PD-L1 expression in intrahepatic cholangiocarcinoma (ICC). Regulation by was confirmed human ICC cell lines. Sequencing the methylome identified mRNA direct target modification whose levels were regulated ALKBH5....
Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport catabolism in liver. However, the role of intestinal PPARα lipid homeostasis is largely unknown. Here, was examined for its modulation obesity NASH. Approach Results Intestinal activated acid‐binding protein 1 (FABP1) up‐regulated humans with high‐fat diet (HFD)–fed mice as revealed by using human intestine specimens or HFD/high‐fat, high‐cholesterol, high‐fructose (HFCFD)‐fed C57BL/6N...
Abstract The role of the pectoralis major myocutaneous flap (PMMF) in head and neck reconstruction is challenged recently due to its natural drawbacks popularity free flaps. This study was designed evaluate indications reliability using a PMMF current era based on single center experience. harvested as pedicle-skeletonized flap, with skin paddle caudally medially areola, including third intercostal perforator, preserving upper one muscle. passed via submuscular tunnel over clavicle. One...
Background and Aims HCC is a leading cause of cancer‐related deaths globally with poor outcome limited therapeutic options. Although the myelocytomatosis ( MYC ) oncogene frequently dysregulated in HCC, it thought to be undruggable. Thus, current study aimed identify critical downstream metabolic network develop therapies for MYC‐driven HCC. Approach Results Liver cancer was induced mice hepatocyte‐specific disruption Myc control by administration diethylnitrosamine. Liquid chromatography...
Abstract Currently, the incidence of acute liver injury (ALI) is increasing year by year, and infection with coronavirus disease 2019 (COVID‐19) can also induce ALI, but there are still no targeted therapeutic drugs. ZnO–NiO particles mainly used to clean up reactive oxygen species (ROS) in industrial wastewater, it insoluble water. Its excellent properties discovered improved adding shuttle‐based bonds make more water‐soluble. ZnO‐NiO@COOH synthetically applied treat ALI. The p‐n junction...
A biomimetic multifunctional nanoreactor is developed by encapsulating glucose oxidase and gold nanorods (AuNRs) in an erythrocyte membrane camouflaged metal–organic framework (MOF) nanoparticle (ZGAM).
A kinase anchor protein 12（AKAP12）is a scaffold that is critical for cell structure maintenance and signal transduction. However, the role of AKAP12 in liver injury remains unclear. Here, we attempt to explore potential contribution elucidate its underlying molecular mechanism. We found deletion acute (ALI) activates PI3K/AKT phosphorylation signaling pathway, induces increased expression PCSK6 downstream inflammation-related genes, prompts macrophages produce large number inflammatory...
Mutations in JAK2, MPL and CALR are highly relevant to the Philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPNs). We performed high resolution melting analysis Sanger sequencing together with T-A cloning elucidate unique mutation profile of these genes, Chinese patients MPNs. Peripheral blood DNA samples were obtained from 80 polycythemia vera (PV), essential thrombocytosis (ET) 50 primary myelofibrosis (PMF). Ten PV identified diverse JAK2 exon 12 mutations. Five novel...
BACKGROUND The objective of this study was to analyze the effects general anesthesia in cesarean section on umbilical cord blood gas values and intraoperative hemodynamics parturient women. MATERIAL AND METHODS A total 112 women who received were eventually randomized into 2 groups, GA (general anesthesia) group (n=56), SE (combined spinal epidural (n=56). values, postpartum Apgar score, loss, mean arterial pressure, heart rate, operative time, time intervals from delivery skin incision...
A-kinase anchor protein 12 (AKAP12; also known as Gravin) functions a tumor suppressor in several human primary cancers. However, the potential correlation between histone deacetylase 3 (HDAC3) and AKAP12 underlying mechanisms remain unclear. Thus, this study, an aim to shed light into matter, expression levels of HDAC3 96 colorectal cancer (CRC) adjacent non-cancerous tissues, well SW480 cells were examined by immunohistochemical, RT-qPCR western blot analyses. The effects on proliferation,...
Objectives: To describe the polymorphisms of gene cassette promoters class 1 integron in clinical Proteus isolates and their relationship with antibiotic resistance. Methods: Polymorphisms promoter 153 strains were analyzed by PCR nucleotide sequencing. Variable regions atypical integrons detected inverse Enterobacterial repetitive intergenic consensus (ERIC) -PCR was used to analyze phylogenetic relationships integron-positive isolates. Representative beta-lactamase genes (bla), including...
Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 3 ( PLOD3 ) is related to a variety of human diseases. However, its function in Colorectal cancer (CRC) remains uncertain. expression was analyzed using The Cancer Genome Atlas (TCGA) pan-cancer data. DAVID used for enrichment analysis -related genes. correlation between and immune cell infiltration evaluated. Four profile datasets (GSE17536, GSE39582, GSE74602, GSE113513) from Gene Expression Omnibus, two proteomic were as validation cohorts...
This study aimed to establish a quantitative droplet-digital polymerase chain reaction (ddPCR) detection system for clinical hepatitis B virus (HBV) DNA in samples from patients with HBV infection the aim of monitoring fluctuations and planning future antiviral treatments. Primers probes conserved region sequence (GenBank: AB554017.1) were designed by alignment GenBank. The PUC57 plasmid containing gene fragment was then synthesized according amplified primer. Linear templates obtained...