A5062642936- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- Head and Neck Cancer Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Cancer Treatment and Pharmacology
- Cancer-related gene regulation
- Bone Metabolism and Diseases
- Bone health and treatments
- Neurogenesis and neuroplasticity mechanisms
- Immunotherapy and Immune Responses
- Intracerebral and Subarachnoid Hemorrhage Research
- Autophagy in Disease and Therapy
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Lung Cancer Diagnosis and Treatment
- Immune cells in cancer
- Radiopharmaceutical Chemistry and Applications
- Inflammatory mediators and NSAID effects
Zhejiang University
2023-2025
Chengdu Women's and Children's Central Hospital
2025
University of Electronic Science and Technology of China
2025
Wenzhou Medical University
2025
Yangzhou University
2024-2025
Zhengzhou University
2023-2025
Henan Provincial People's Hospital
2023-2025
General Hospital of Shenyang Military Region
2025
Wenzhou Hospital of Traditional Chinese Medicine
2025
First Affiliated Hospital of Wenzhou Medical University
2025
Programmed cell death 1 (PD-1) and one of its ligands, PD-L1, are key immune checkpoint proteins. Evidences showed PD-L1 is an emerging biomarker for immunotherapy by anti-PD-1 anti-PD-L1 antibody in non-small lung cancer (NSCLC). To investigate the association protein expression with clinicopathological features impact on survival outcome, we conducted a meta-analysis.A comprehensive literature search electronic databases (up to July 10, 2014) was performed. Correlation between overall (OS)...
Abstract Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare and distinct subtype of primary lung cancer characterized by Epstein-Barr virus (EBV) infection. Herein, we reported the mutational landscape pulmonary LELC using whole-exome sequencing, targeted deep sequencing single-nucleotide polymorphism arrays. We identify low degree somatic mutation but widespread existence copy number variations. reveal predominant signature 2 mutations frequent loss type I interferon genes that are...
Abstract Background Neuroinflammation and blood-brain barrier (BBB) disruption are two vital mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Recently, melanocortin-1 receptor (Mc1r) activation by Nle4-D-Phe7-α-MSH (NDP-MSH) was shown to play a neuroprotective role in an experimental autoimmune encephalomyelitis (EAE) mouse model. This study aimed investigate whether NDP-MSH could alleviate neuroinflammation BBB after ICH, as well the potential its roles....
GEM20110714 (ClinicalTrials.gov identifier: NCT01528618), the first randomized, phase III study of systemic chemotherapy in recurrent or metastatic nasopharyngeal carcinoma (NPC), reported significant progression-free survival improvement with gemcitabine plus cisplatin (GP) versus fluorouracil (FP; hazard ratio, 0.55; 95% CI, 0.44 to 0.68;
Disturbance of macrophage-associated lipid metabolism plays a key role in atherosclerosis. Crosstalk between autophagy deficiency and inflammation response foam cells (FCs) through epigenetic regulation is still poorly understood. Here, we demonstrate that macrophages, oxidized low-density lipoprotein (ox-LDL) leads to abnormal crosstalk inflammation, thereby causing aberrant mediated dysfunctional transcription factor EB (TFEB)-P300-bromodomain-containing protein 4 (BRD4) axis. ox-LDL led...
Inflammation-driven endothelial dysfunction is the major initiating factor in atherosclerosis, while underlying mechanism remains elusive. Here, we report that non-canonical stimulator of interferon genes (STING)-PKR-like ER kinase (PERK) pathway was significantly activated both human and mice atherosclerotic arteries. Typically, STING activation leads to regulatory 3 (IRF3) nuclear factor-kappa B (NF-κB)/p65, thereby facilitating IFN signals inflammation. In contrast, our study reveals...
This study aims to develop and validate a nomogram based on the Systemic Inflammatory Response Index (SIRI) predict short-term aortic-related adverse events (ARAEs) in patients with acute uncomplicated Type B intramural hematoma (IMH). We retrospectively analyzed 332 diagnosed IMH between April 2018 2024. Patients were categorized into stable group (N=225) exacerbation (N=107) occurrence of ARAEs within 30-day observation period. SIRI was calculated using neutrophil, monocyte, lymphocyte...
Accumulating studies have indicated that reactive oxygen species (ROS) may be implicated into the destructive pathological events of rheumatoid arthritis (RA). As an effective antioxidant, artesunate (ARS) was reported to exert antiarthritic effects. However, whether ARS attenuates bone erosion during RA progression by regulating ROS production remains defined. To address this problem, inhibitive effects on osteoclastogenesis were observed in vitro. Mechanically, significantly inhibited...
The limited understanding of the pathological mechanisms intracerebral hemorrhage (ICH) and absence successful therapies lead to poor prognoses for patients with ICH. Dihydromyricetin (DMY) has many physiological functions, such as regulating lipid glucose metabolism modulating tumorigenesis. Moreover, DMY been proven be an effective treatment neuroprotection. However, no reports date have made regarding impact on ICH.This investigation aimed identify role ICH in mice underlying...
Brain-derived neurotrophic factor (BDNF), via activation of TrkB receptors, mediates vital physiological functions in the brain, ranging from neuronal survival to synaptic plasticity, and has been implicated pathophysiology neurodegenerative disorders. Although transcriptional regulation BDNF gene ( Bdnf ) extensively studied, much remains be understood. We discovered a sequence within promoter 4 that binds basic helix-loop-helix protein BHLHB2 is target for BHLHB2-mediated repression. NMDA...
Accumulating evidence indicates that inflammation plays a critical role in cancer development; however, mechanisms of immunosuppression hinder productive anti-tumor immunity to limit immunopathology. Tumor-specific cytotoxic T lymphocyte (CTL) dysfunction or exhaustion by upregulating inhibitory receptors such as programmed cell death 1 (PD-1) tumor-bearing hosts is one mechanism. Identification and blockade the pathways induce CTL has been shown partially restore function hosts....
Cervical cancer is a common malignant tumour of the female reproductive system that seriously threatens health women.The aims this study were to identify key genes and pathways illuminate new molecular mechanisms underlying cervical cancer.Altogether, 1829 DEGs identified, including 794 significantly down-regulated 1035 up-regulated DEGs.GO analysis suggested mainly enriched in mitotic cell cycle processes, DNA replication, organelle fission, chromosome segregation phase transition,...
Respiratory syncytial virus (RSV) infects the central nervous system, resulting in neurological symptoms. However, precise underlying pathogenic mechanisms have not been elucidated. In present study, infectivity of RSV on N2a neuronal cells and possible roles Toll-like receptor 4 (TLR4) nucleolin (C23) during infection were investigated.We compared two experimental groups (infected non-infected) monitored viral titers culture supernatant by a plaque assay. We also inspected morphology...
Abstract Nasopharyngeal carcinoma (NPC) has the highest rate of metastasis among head and neck cancers, distant is major reason for treatment failure. We have previously shown that high cyclooxygenase‐2 (COX‐2) expression associated with a poor prognosis patients NPC inhibits chemotherapy‐induced senescence in cells. In this study, we found COX‐2 was upregulated cancer‐associated fibroblasts (CAFs) derived from by RNA‐Seq. Furthermore, elevated CAF detected survival using...