A5100440618- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Cancer Treatment and Pharmacology
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Viral Infectious Diseases and Gene Expression in Insects
- T-cell and B-cell Immunology
- Platelet Disorders and Treatments
- Metabolomics and Mass Spectrometry Studies
- Lung Cancer Treatments and Mutations
- Blood properties and coagulation
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Cancer-related gene regulation
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Obstetrics and Gynecology Hospital of Fudan University
2015-2025
Shanxi University
2022-2025
Beijing University of Agriculture
2021-2025
Fujian Provincial Cancer Hospital
2025
Fujian Medical University
2025
Shandong University
2024
Zhejiang Chinese Medical University
2023-2024
Hubei Provincial Center for Disease Control and Prevention
2021-2024
Purpose The MURANO study demonstrated significant progression-free survival (PFS) benefit for fixed-duration venetoclax-rituximab compared with bendamustine-rituximab in relapsed/refractory chronic lymphocytic leukemia. With all patients off treatment, we report minimal residual disease (MRD) kinetics and updated outcomes. Methods Patients were randomly assigned to 2 years of venetoclax plus rituximab during the first six cycles, or cycles bendamustine-rituximab. Primary end point was PFS....
Hepatitis E virus (HEV) represents the main cause of acute hepatitis worldwide. HEV infection in immunocompromised patients involves a high risk for development chronic hepatitis. Because is recognized as zoonotic pathogen, it currently believed that swine primary reservoir. However, this not sufficient to justify strikingly seroprevalence both developing and Western countries. Thus, study aimed identify new sources bear transmission humans. We collected fecal, blood, milk samples cows...
In previous analyses of the MURANO study, fixed-duration venetoclax plus rituximab (VenR) resulted in improved progression-free survival (PFS) compared with bendamustine (BR) patients relapsed or refractory chronic lymphocytic leukemia (CLL). At 4-year follow-up, we report long-term outcomes, response to subsequent therapies, and predictive value molecular genetic characteristics.Patients CLL were randomly assigned 2 years (VenR for first six cycles) cycles BR. PFS, overall (OS),...
The link between gut microbes and autism spectrum disorders (ASD) has been already observed in some studies, but bacterial families/species were found to be inconsistently up or down regulated. This issue rarely explored the Chinese population. In this study, we assessed whether not microbiota dysbiosis was associated with children ASD China. We enrolled 45 (6-9 years of age; 39 boys 6 girls) sex- age-matched neurotypical children. Dietary other socio-demographic information obtained via...
Background. Transplant tolerance, rather than immunity, may be favored in the setting of a lower mature lymphoid mass recipient induced by anti-T cell agents. A novel immunosuppressive agent, FN18-CRM9, known to specifically kill T cells with great potency, was evaluated transplant model. Methods. In order ablate cells, immunotoxin FN18-CRM9 administered rhesus monkey recipients MHC-mismatched renal allografts. Donor lymphocytes were injected intrathymically into some animals. Results. All...
Luteolin has been reported to attenuate ischemia/reperfusion (I/R) injury in the diabetic heart through endothelial nitric oxide synthase- (eNOS-) related antioxidative response. Though nuclear factor erythroid 2-related 2 (Nrf2) is regarded as a key endogenous reduce oxidative stress, whether luteolin reduces cardiac I/R via enhancing Nrf2 function needs be clarified. We hypothesized that pretreatment with could alleviate by affecting eNOS/Nrf2 signaling pathway. The rat was produced single...
This phase 1b trial (NCT02670044) evaluated venetoclax-idasanutlin in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) ineligible for cytotoxic chemotherapy. Two-dimensional dose escalation (DE, n = 50) was performed venetoclax daily idasanutlin on days 1 to 5 28-day cycles, followed by dosing schedule optimization (n 6) evaluate reduced schedules (21-/14-day dosing). Common adverse events (occurring ≥40% of patients) included diarrhea (87.3% patients), nausea (74.5%),...
Recent studies have shown that the combined use of renin angiotensin system inhibitor, SGLT2 inhibitors and/or mineralocorticoid receptor antagonist provides additional renal protection for patients with diabetic kidney disease (DKD). Similarly, in traditional Chinese medicine, synergistic application multiple herbs often brings more significant therapeutic effects. However, or additive mechanisms medicine combination therapy are not fully understood. In our previous studies, we show...
The attachment of the blastocyst to uterine luminal epithelium and subsequent invasion by trophoblast cells through stroma deciduum occur in a highly regulated manner remodeling extracellular matrix. We investigated temporal spatial expression mRNAs for four matrix metalloproteinases (MMPs; MMP-2 [gelatinase A], MMP-3 [stromelysin 1], MMPs; B], MMP-13 [collagenase 3]) tissue inhibitors (TIMPs; TIMP-1, TIMP-2, TIMP-3) mouse uterus from days 1 8 pregnancy. Northern blot analyses showed...
Streptomyces chattanoogensis L10 is the industrial producer of natamycin and has been proved a highly efficient host for diverse natural products. It an enormous potential to be developed as versatile cell factory production heterologous secondary metabolites. Here we genome-reduced chassis by rational 'design-build-test' pipeline. To identify candidate large non-essential genomic regions accurately design deletion rationally, performed genome analyses S. multiple computational approaches,...
Activation of purinergic receptors by extracellular ATP (eATP) released from injured cells has been implicated in the pathogenesis many neuronal disorders. The P2X7 receptor (P2X7R), an ion-selective receptor, is associated with microglial activation and paracrine signaling. However, whether P2X7R are involved radiation-induced brain injury (RBI) remains to be determined. Here, we found that eATP level was elevated cerebrospinal fluid (CSF) RBI patients clinical severity disorder. In our...
Suckling piglets were used to investigate the response of colonic mucosa-associated microbiota composition, mucosal immune homeostasis, and barrier function early life galactooligosaccharides (GOS) intervention. Ten milliliter 1 g/kg body weight GOS solutions physiological saline fed newborn in group control (CON) a week time, respectively. Six from each euthanized on day 8 21. had higher abundance short-chain fatty acids (SCFAs) producer such as Prevotella, Barnesiella, Parabacteroides,...
The lack of effective treatments against the 2019 coronavirus disease (COVID-19) has led to exploratory use convalescent plasma for treating COVID-19. Case reports and case series have shown encouraging results. This study investigated SARS-CoV-2 antibodies epidemiological characteristics in donors, identify criteria donor selection.Recovered COVID-19 patients, aged 18-55 years, who had experienced no symptoms more than 2 weeks, were recruited. Donor such as presentations collected...
<h3>Background</h3> Chimeric antigen receptor-modified (CAR) T-cell immunotherapy is a novel promising therapy for treatment of B-cell malignancy. Cytokine release syndrome (CRS) and infection are the most common adverse events during CAR therapy. Similar clinical presentation concurrent CRS makes it difficult to differentially diagnose timely treat condition. <h3>Methods</h3> We analyzed features first 30 days after infusion (CTI) in 109 patients from three trials (ChiCTR-OPN-16008526,...
High-dose chemotherapy followed by autologous stem cell transplantation (HDT-ASCT) is the standard of care for chemosensitive relapsed or refractory (R/R) aggressive B lymphoma. Patients with a positive positron emission tomography (PET) scan before ASCT have poor prognosis, and those who fail to achieve therapeutic response better than partial remission after salvage treatment are ineligible candidates ASCT. We conducted this open-label single-arm prospective clinical study evaluate safety...
Abstract Chimeric antigen receptor (CAR) T-cell immunotherapy following autologous stem cell transplantation (ASCT) is a promising method for refractory or relapsed multiple myeloma, but explicit data central nervous system lymphoma (CNSL) are lacking. Here, we treated 13 CNSL patients with ASCT sequential CD19/22 CAR infusion and simultaneously evaluated the clinical efficacy toxicity. The analyzed included four primary nine secondary patients. Patients 1 10, who had complete remission...