A5100784191- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Blood transfusion and management
- Blood donation and transfusion practices
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Long-Term Effects of COVID-19
- Blood groups and transfusion
- HIV Research and Treatment
- COVID-19 and healthcare impacts
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- HIV/AIDS Research and Interventions
- COVID-19 Impact on Reproduction
- HIV/AIDS drug development and treatment
- Acute Ischemic Stroke Management
- SARS-CoV-2 detection and testing
- Cytokine Signaling Pathways and Interactions
- Liver Disease Diagnosis and Treatment
- COVID-19 epidemiological studies
- Immune Response and Inflammation
- Computational Drug Discovery Methods
- Free Radicals and Antioxidants
- Immune Cell Function and Interaction
- Medical Research and Treatments
- Herpesvirus Infections and Treatments
Fujian Medical University
2023-2025
Third Affiliated Hospital of Southern Medical University
2024
Wuhou District People's Hospital, Chengdu
2024
Southern Medical University Shenzhen Hospital
2023-2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
McMaster University
2024
Impact
2024
Northeast Agricultural University
2024
Zhongda Hospital Southeast University
2024
<h3>Importance</h3> Convalescent plasma is a potential therapeutic option for patients with coronavirus disease 2019 (COVID-19), but further data from randomized clinical trials are needed. <h3>Objective</h3> To evaluate the efficacy and adverse effects of convalescent therapy COVID-19. <h3>Design, Setting, Participants</h3> Open-label, multicenter, trial performed in 7 medical centers Wuhan, China, February 14, 2020, to April 1, final follow-up 28, 2020. The included 103 participants...
An epidemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread unexpectedly in Wuhan, Hubei Province, China, since December 2019. There are few reports about asymptomatic contacts of infected patients identified as positive for SARS-CoV-2 through screening. We studied the epidemiological and clinical outcomes 55 carriers who were laboratory confirmed to be nucleic acid testing pharyngeal swab samples. The seldom occurred among young people (aged 18-29...
The lack of effective treatments against the 2019 coronavirus disease (COVID-19) has led to exploratory use convalescent plasma for treating COVID-19. Case reports and case series have shown encouraging results. This study investigated SARS-CoV-2 antibodies epidemiological characteristics in donors, identify criteria donor selection.Recovered COVID-19 patients, aged 18-55 years, who had experienced no symptoms more than 2 weeks, were recruited. Donor such as presentations collected...
Abstract Background COVID-19 has caused a global pandemic and the death toll is increasing. However, there no definitive information regarding type of clinical specimens that best for SARS-CoV-2 detection, antibody levels in patients with different duration disease, relationship between level viral load. Methods Nasopharyngeal swabs, anal saliva, blood, urine were collected from course disease ranging 7 to 69 days. Viral load specimen types was measured using droplet digital PCR (ddPCR)....
The effect of different high pressure homogenization energy input parameters on mean diameter droplet size (MDS) and droplets with > 5 μm lipid injectable emulsions were evaluated. All prepared at water bath temperatures or rotation speeds rotor-stator system times, using pressures numbers high-pressure recirculations. MDS polydispersity index (PI) value the determined dynamic light scattering (DLS) method, large-diameter tail assessments performed light-obscuration/single particle optical...
There are few data available on the prevalence, incidence, and residual risk of transfusion-transmitted HBV (TT-HBV) infections among Chinese blood donors. This study investigated demographic characteristics donors, as well (RR) TT-HBV in six large centers different regions China. The screening test results donors from China were collected analyzed. hepatitis B surface antigen (HBsAg) yield approach was used to estimate incidence HBV. Then, RR evaluated using incidence-window period model....
BackgroundBecause treatment options for coronavirus disease 2019 (COVID-19) are very limited, the use of convalescent plasma has bee explored.Case presentation and treatmentA male centenarian with cough dyspnea 2 months was diagnosed COVID-19. Without effective treatments increased risks antiviral therapy elderly, this patient given plasma. The viral load, complete blood count, inflammatory indicators, vital signs, clinical symptoms were observed before after COVID-19...
Dicaffeoylquinic acids (diCQAs) are found in a variety of edible and medicinal plants with various biological activities. An important issue is the low stability diCQAs during extraction food processing, resulting degradation transformation. This work used 3,5-diCQA as representative to study influence different parameters ultrasonic treatment on diCQAs, including solvent, temperature, time, power, duty cycle, probe immersion depth. The generation free radicals its were investigated...
Introduction: As coronavirus Disease 2019 (COVID-19) has evolved into a global pandemic, increasing numbers of reports have linked obesity to more severe COVID-19 illness and death. However, almost all the studies focused on an increased risk mortality or intensive care unit (ICU) admission among hospitalized obese patients with COVID-19. Is also associated incidence acute lung injury (ALI) in COVID-19? How about underweight patients? The answer is lacking. Therefore, our following research...
We investigated HPV in adenocarcinoma presenting and managed as cervical (CADC) at seven major representative regional cancer centres across China. From 1,051 CADC cases diagnosed locally 2005-2010, 881 had available paraffin embedded tissue. Initial review excluded 154 other diagnoses or inappropriate specimens. In 718 eligible consensus panel pathology diagnosis was made using an algorithm incorporating p16 progesterone receptor immunohistochemistry (IHC). Classification of categories...
A novel coronavirus has caused an international outbreak. Currently, there are no specific therapeutic agents for infections. Convalescent plasma (CP) therapy is a potentially effective treatment option.Patients who had recovered from COVID-19 and been discharged the hospital more than 2 weeks were recruited. convalescent (CCP)-specific donor screening selection performed based on following criteria: 1) aged 18-55 years; 2) eligible blood donation; 3) diagnosed with COVID-19; 4) two...
Transfusion-related acute lung injury (TRALI) is one of the most serious adverse events following transfusion, and there no specific treatment in clinical practice. However, regulatory T cells (Tregs) have been suggested to play a potential role TRALI. This study investigated whether interleukin (IL)-2 or IL-2/anti-IL-2 complexes (IL-2c), which are mediators Treg expansion, can modulate severity antibody-mediated TRALI vivo.This utilized mouse model "two-hit" mechanism: BALB/c mice were...
Glioblastoma is carcinogenesis of glial cells in central nervous system and has the highest incidence among primary brain tumors. Brain metastasis, such as breast cancer lung cancer, also leads to high mortality. The available medicines are limited due blood-brain barrier. Abnormal activation phosphatidylinositol 3-kinases (PI3K) signaling pathway prevalent glioblastoma metastatic Here, we characterized a 2-amino-4-methylquinazoline derivative XH30 potent PI3K inhibitor with excellent...
BackgroundThe high prevalence of hepatitis B virus (HBV) among the Chinese population poses a threat to blood safety; however, few studies have examined epidemiological data regarding HBV infection donors. The present study investigated demographic characteristics donors at Anhui center in China, prevalence, incidence, and residual risk (RR) associated with surface antigen (HBsAg) expression terms transfusion transmitted (TTHBV) infections. MethodsThe status people who donated between 2009...
Background To evaluate the role of ST-segment resolution (STR) alone and in combination with Thrombolysis Myocardial Infarction (TIMI) flow reperfusion evaluation after primary percutaneous coronary intervention (PPCI) for ST-segment-elevation myocardial infarction by investigating long-term prognostic impact. Methods Results From January 2013 through September 2014, we studied 5966 patients enrolled CAMI (China Acute Infarction) registry available data STR evaluated at 120 minutes PPCI....
Pulmonary tuberculosis (TB) is a severe infectious respiratory disease, the burden of which remains high in China. To provide scientific evidence for developing more targeted prevention and control strategies, this study aimed to determine incidence trends explore epidemiological characteristics pulmonary TB Anhui Province, Eastern China between 2013 2018.The retrospective analyzed information regarding cases reported by National Infectious Disease Reporting System census data collected from...
Abstract Topical immunotherapy with diphenylcyclopropenone (DPCP) is considered to be the most effective treatment of severe AA. However, mechanism unclear and an early predictor for efficacy needs explored. The TSLP/OX40L/IL‐13 pathway important initiate maintain Th2 immune responses. Our previous work suggests this may play a role in AA treated DPCP. Thus, further investigate DPCP explore therapy, we conducted prospective study compare expression levels TSLP, OX40L, cytokines IL‐4, IL‐5...
To use systematic pharmacological strategies to explore the regulatory mechanisms of Ma Xing Shi Gan Decoction (MXSGD) against coronavirus disease 2019 (COVID-19). Data on compounds and targets MXSGD were collected from Traditional Chinese Medicene Systems Parmacology Database Analysis Platform (TCMSP) TCM Databases@Taiwan. ACE2-related protein-protein interaction (PPI) String database. The Cytoscape 3.7.2 was used construct analyze networks. DAVID platform for Gene Ontology (GO) pathway...
Abstract Background Dengue virus (DENV) infection is increasingly common in southern China and can be transmitted through blood transfusion but not currently part of donor screening throughout the region. We assessed DENV prevalence among donors at Xishuangbanna Blood Center, Yunnan, to support development strategies. Methods samples were collected randomly between June 2019 August 2019. These screened for anti-DENV IgG IgM using enzyme-linked immunosorbent assay (ELISA). Then, all reactive...
To investigate the clinical characteristics, epidemiological and transmissibility of coronavirus disease 2019 (COVID-19) in a family cluster outbreak transmitted by 3-month-old confirmed positive infant.Field-based methods were used to cases their close contacts. Real-time fluorescent reverse transcription polymerase chain reaction (RT-PCR) was detect Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) for all collected specimens. Serum SARS-CoV-2 IgM IgG antibodies detected...