A5024297656- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Fermentation and Sensory Analysis
- Long-Term Effects of COVID-19
- Biochemical and biochemical processes
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Viral Infections and Vectors
- Viral-associated cancers and disorders
- Phytochemistry and Biological Activities
- Immunotherapy and Immune Responses
- Phytochemistry and Bioactivity Studies
- Horticultural and Viticultural Research
- Drug-Induced Hepatotoxicity and Protection
- Tea Polyphenols and Effects
- Viral Infections and Outbreaks Research
- COVID-19 and healthcare impacts
- Medicinal Plants and Bioactive Compounds
- Saffron Plant Research Studies
- Flavonoids in Medical Research
- Hops Chemistry and Applications
- Pharmacological Effects of Natural Compounds
- Heme Oxygenase-1 and Carbon Monoxide
- Cytomegalovirus and herpesvirus research
Huazhong University of Science and Technology
2013-2025
Union Hospital
2010-2025
Union Hospital
2023
Sichuan University
2020-2022
The dynamic changes of lymphocyte subsets and cytokines profiles patients with novel coronavirus disease (COVID-19) their correlation the severity remain unclear.
Background: The dynamic changes of lymphocyte subsets and cytokines profiles patients with novel coronavirus disease (COVID-19) their correlation the severity remain unclear. Method: Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 examined for by flow cytometry cytokine specific immunoassays. Findings: Of enrolled, 13 severe cases showed significant sustained decreases in counts but increases neutrophil than 27 mild cases. Further analysis demonstrated T...
Abstract Background The dynamic changes of lymphocyte subsets and cytokines profiles patients with novel coronavirus disease (COVID-19) their correlation the severity remain unclear. Methods Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 examined for by flow cytometry cytokine specific immunoassays. Results Of enrolled, 13 severe cases showed significant sustained decreases in counts but increases neutrophil than 27 mild cases. Further analysis demonstrated...
Nowadays, treatments for cholestasis remain largely nonspecific and often ineffective. Recent studies showed that inflammatory injuries oxidative stress occur in the liver with cholestasis. In this study, we would use corilagin to treat animal model of acute order define activity interfere inflammation-related pathway cholestatic pathogenesis.Rats were administrated alpha-naphthylisothiocyanate establish divided into corilagin, ursodeoxycholic acid, dexamethasone, normal groups treatment...
This study employed computational biology approaches to investigate the interactions between per- and polyfluoroalkyl substances (PFAS) key colorectal cancer (CRC) proteins. The results indicate that PFAS may influence CRC progression by modulating multiple proteins, particularly glutathione S-transferase A1 (GSTA1). Computational analysis revealed 14 exhibits high binding affinity for GSTA1, occupying its glutathione-binding site. Further simulations confirmed stable of across different...
Despite the availability of an effective vaccine, hepatitis B virus (HBV) infection and its treatment remains one foremost public health problems in world. The present study was performed order to investigate anti-HBV activity lutein vitro. antiviral examined by detecting levels HBsAg, HBeAg extracellular HBV DNA stable HBV-producing human hepatoblastoma HepG2 2.2.15 cells. It found that effectively suppressed secretion HBsAg from cells a dose-dependent manner, it also amount DNA. A...
Introduction: As coronavirus Disease 2019 (COVID-19) has evolved into a global pandemic, increasing numbers of reports have linked obesity to more severe COVID-19 illness and death. However, almost all the studies focused on an increased risk mortality or intensive care unit (ICU) admission among hospitalized obese patients with COVID-19. Is also associated incidence acute lung injury (ALI) in COVID-19? How about underweight patients? The answer is lacking. Therefore, our following research...
This study is to explore the anti-inflammatory mechanism of ethanol extract Duchesnea indica (Andr) Focke. An inflammatory cellular model was established by addition lipopolysaccharide (LPS) on RAW264.7 cell line. The secretion TNF-alpha, IL-1beta, IL-6, NO and IL-10 in supernatant, mRNA expression COX-2, iNOS HO-1, protein COX-2 activation NF-kappaB were assayed ELISA, Griess method, real-time quantitative PCR, Western blot immunocytochemistry respectively. D. not only reduced production...
AIM: To define the potential role of programmed death-1/programmed death-ligand (PD-1/PD-L) pathway in different hepatitis B virus (HBV) infection disease status; we examined expression PD-1 on antigen specific CD8+ T cells peripheral blood patients with chronic (CHB) and acute exacerbation (AEHB) infection. METHODS:The level lymphocytes number HBV healthy controls (HCs) were analyzed by staining pentameric peptide-human leukocyte antigen2 (HLA2) complexes combined flow cytometry.Real-time...
Ampelopsis sinica root is widely used in Chinese folk medicine for treating liver disorders caused by the hepatitis B virus (HBV). The present study was performed order to investigate anti‐HBV activity and mechanisms of ethanol extract from A. (EASR) vitro. antiviral EASR examined detecting levels HBsAg, HBeAg extracellular HBV DNAs stable HBV‐producing human hepatoblastoma HepG2 2.2.15 cells. We found that effectively suppressed secretion HBsAg cells a dose‐dependent manner, it also amount...
The application of intracellular and extracellular Epstein-Barr virus (EBV) DNA in allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been poorly characterized. We conducted a combined prospective-retrospective study 300 patients who underwent allo-HSCT between 2016 to 2019 our center monitored for EBV within the first year after HSCT. Combining optimal cut-off value load (7.3×104 copies/106 cells) peripheral blood mononuclear cells (PBMCs) qualitative detection plasma (400...
This study is to explore the inner anti-inflammatory mechanism of ethanol extract Rungia pectinata (Linn.) Nees. As a result, Nees could not only strongly reduce production pro-inflammatory cytokines and mediators via blocking NF-kappaB activation but slightly promote release mediator HO-1 suppress IL-10 secretion. In conclusion, compared Dexamethasone, has similar effects on antagonizing also mild promoting mediators.
Objective To analyze the changing trend of absolute number and constituent ratio various in-patient diseases in Department Infectious Diseases a large general hospital Central China during 2013–2019. Methods A retrospective study was conducted to diagnostic data discharged patients for seven consecutive years, from 2013 2019. The first discharge diagnosis is used as basis disease classification. number, ratio, major hepatobiliary infectious were analyzed. Results 2013–2019 showed that cases...
Background Invasive pulmonary aspergillosis (IPA) typically occurs in immunocompromised individuals. Severe fever with thrombocytopenia syndrome (SFTS) patients are characterized by fever, thrombocytopenia, and leukopenia. These present dysregulation of cellular humoral immunity, which may predispose them to IPA. Our study aimed identify risk factors for SFTS-associated invasive (SAPA) evaluate its associated prognostic impact. Methods We conducted a cohort between January 2017 December 2022...
Background: As COVID-19 evolved into a global pandemic. Increasing numbers of reports have linked obesity to more severe illness and death (1-3). However, almost all the studies focused on proportion people entering ICU or mortality. Is also associated with severity pneumonia in common patients? How about underweight The answer is lack. So, our research below will question. Methods: We collected analyzed epidemiological, demographic, clinical, laboratory data from 193 confirmed cases at...