A5081534462- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Cancer Immunotherapy and Biomarkers
- Acupuncture Treatment Research Studies
- Gastric Cancer Management and Outcomes
- Healthcare and Venom Research
- Esophageal Cancer Research and Treatment
- Cancer survivorship and care
- Advanced Radiotherapy Techniques
- Nausea and vomiting management
- Radiomics and Machine Learning in Medical Imaging
- Hepatitis B Virus Studies
- Neuroendocrine Tumor Research Advances
- Soil Carbon and Nitrogen Dynamics
- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis C virus research
- Esophageal and GI Pathology
- Cancer therapeutics and mechanisms
- Neutropenia and Cancer Infections
- Brain Metastases and Treatment
- Wastewater Treatment and Nitrogen Removal
Nantong University
2025
Affiliated Hospital of Nantong University
2025
Sichuan University
2014-2024
Air Force Medical University
2013-2024
Xijing Hospital
2013-2024
West China Hospital of Sichuan University
2014-2024
Shandong University of Traditional Chinese Medicine
2024
Xidian University
2024
Guangzhou University
2023-2024
Wuhan Hankou Hospital
2024
Focal adhesion kinase (FAK) is overexpressed in a variety of cancers, such as breast, colon, prostate, ovary, and lung cancers. However, the mechanism by which extracellular matrix fibronectin stimulates cancer cell migration invasion through FAK remains to be investigated. The signalling pathways fibronectin-mediated were examined using western blotting. metastasis function was detected wound healing, assays. Further, RNA interference inhibitors also used study downstream signals. In this...
Background: The administration of immune checkpoint inhibitors (ICIs) in advanced non-small cell lung cancer (NSCLC) with oncogenic driver alterations other than epidermal growth factor receptor (EGFR) aroused a heated discussion. We thus aimed to evaluate ICI treatment these patients real-world routine clinical practice. Methods: A multicenter, retrospective study was conducted for NSCLC at least one gene alteration (KRAS, HER2, BRAF, MET, RET, ALK, ROS1) receiving monotherapy or...
Periodontitis is a chronic inflammatory disease that seriously affects the quality of patients' life. Diabetes mellitus (DM) independent risk factor periodontitis. The association between vitamin B6 with several diseases have been reported in previous studies. However, effect on T2DM and periodontitis remains unclear. This study aimed to explore [evaluated by serum pyridoxal 5'-phosphate (PLP)] American population. Data this cross-sectional were extracted from National Health Nutrients...
Extranodal follicular dendritic cell sarcoma (FDCS) of the pharyngeal region is a rare malignant tumor recognized in recent years, with approximately 37 cases so far reported literature. It often not considered at initial evaluation and may be misdiagnosed small biopsy specimen. We report 4 extranodal FDCS, 2 nasopharynx that were diagnosed as undifferentiated carcinomas because they characterized by syncytial epithelial cells sheet or nest-like distribution tonsil soft palate vaguely...
Abstract Purpose To evaluate the treatment outcome of salvage concurrent radio-chemotherapy for patients with loco-recurrent esophageal cancer after surgery. Methods 50 squamous-cell curative esophagectomy were retrospectively analyzed. Patients treated radiotherapy (median 60 Gy) combined chemotherapy consisting either 5-fluorouracil (5-FU) plus cisplatin (DDP) (R-FP group) or paclitaxel DDP (R-TP group). Results The median follow-up period was 16.0 months. 1-year and 3-year survival rates...
Abstract Background The NCCN (National Comprehensive Cancer Network) Clinical Practice Guidelines in Oncology (NCCN guidelines) recommend radical resection for T1-2N0M0 patients with limited-stage small cell lung cancer (LS-SCLC). However, only about 5% of (SCLC) were initially diagnosed as T1-2N0M0. purpose our study was to analyze and compare the effects comprehensive treatment including surgery concurrent chemoradiotherapy on prognosis LS-SCLC. Methods We comprehensively reviewed medical...
Although immune checkpoint inhibitors (ICIs) provide unprecedented survival improvement for patients with advanced non-small cell lung cancer (NSCLC), disease progression inevitably occurs. After ICIs failure, limited data exist on whether ICI-based treatment beyond (TBP) may be beneficial to NSCLC. This retrospective study aimed evaluate the efficacy of this approach in NSCLC and identify potential factors.Patients stage IV who received after failure prior PD-1/PD-L1 inhibitor treatments...
Low-dose radiotherapy (LDRT) may enhance the synergistic antitumor effect of combined immunotherapy and stereotactic body (SBRT). The safety efficacy this novel triple-combination therapy were evaluated for first time as first-line treatment patients with metastatic non-small cell lung cancer (NSCLC).This prospective phase I study enrolled 29 included a dose-escalation dose-expansion phase. Patients received SBRT [30 Gray (Gy)/3f] to small lesions LDRT (2 Gy/1f, 4 Gy/2f, or 10 Gy/5f) large...
Pulmonary fibrosis (PF) is a disease characterised by diffuse nonspecific alveolar inflammation with interstitial fibrosis, which clinically manifests as dyspnoea and significant decline in lung function. Many studies have shown that the epithelial–mesenchymal transition (EMT) plays pivotal role pathogenesis of pulmonary fibrosis. Based on our previous findings, hypericin (Hyp) can effectively inhibit process EMT to attenuate Therefore, series hyperoside derivatives were synthesised via...
Protocadherin8 (PCDH8), an integral membrane protein, was reported to be a tumor suppressor involved in tumorigenesis cancers. We aimed investigate the epigenetic inactivation of PCDH8 and its tumor-suppressor function nasopharyngeal carcinoma (NPC). Frequent downregulation/silencing found NPC cell lines using semiquantitative PCR. Promoter methylation observed 100% (5/5) 85.3% (35/41) primary tumors by methylation-specific PCR, but not normal tissues. Treatment cells with...
Abstract Purpose This study was conducted to evaluate the effectiveness and safety of intensity-modulated radiotherapy (IMRT) concurrent paclitaxel plus cisplatin (TP regimen) for upper esophageal carcinoma. Methods 36 patients carcinoma were retrospectively analyzed. Patients treated with IMRT (median 60 Gy) combined TP regimen chemotherapy. The Kaplan-Meier analysis performed in statistical analysis. Toxicities recorded according NCI CTC version 3.0. Results aged 43–73 years 57 years)....
It is acknowledged that trees biomass allocation in response to environmental conditions. However, it remains poorly understood what strategies of plant with inter- and intraspecific interactions tree species forest stands. Such information important for revealing competition. To address this problem, a study was conducted Larix principis-rupprechtii plantations evaluate the impact competition on Shanxi Province, China. We measured index (CI), stem, branch, foliage, root as well element...
Differently from epidermal growth factor receptor (EGFR) 19Del and L858R mutations, the panoramic description of uncommon EGFR mutations is far mature. Our understanding its population characteristics, treatment response, drug resistance mechanisms needs urgent expansion deepening. study enrolled 437 patients with non-small-cell lung cancer four clinical centers who had mutations. The characteristics all outcomes 190 advanced received pharmacotherapy were analyzed. Moreover, acquired...
Abstract Background Chemotherapy is an important approach for lung cancer patients. The study was designed to evaluate the feasibility of compound probiotic supplements in improving quality life patients undergoing chemotherapy. Methods This randomized, double‐blind, placebo‐controlled trial enrolled chemotherapy‐naive with who were scheduled receive platinum‐based doublet All eligible randomly administered (1:1) (group BP‐1) or placebo C) two chemotherapy cycles. EORTC QLQ C30 questionnaire...
Abstract Background The influence of β -glucan on the human gut microbiota is closely related to physicochemical structure -glucan. We purified a homogeneous water-soluble polysaccharide from Tibetan hull-less barley 25 and studied its in vitro fermentation profile. Results Analysis by gas chromatography (GC), Fourier-transformed infrared (FT-IR), nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), atomic force micrograph (AFM) helped determine be (molecular weight: 3.45 ×...
One-step hydrothermal method has been used to synthesize YMnO 3 @NiO (YMO@NO) photocatalysts with high photocatalytic activity for the degradation of oil and gas field wastewater under simulated solar irradiation. Through various characterization methods, it confirmed that YMO@NO photocatalyst comprises only YMO NO, without any other impurities. The microstructure was composed large squares fine particles, heterojunction formed at interface NO. optical properties confirm UV-vis absorption...
Objective To evaluate the effectiveness of oral probiotic supplements in patients undergoing immune checkpoint inhibitors (ICIs) for treatment advanced lung cancer. Methods This prospective real-world study enrolled with cancer who were receiving ICIs as part their treatment. The divided into 2 groups: Group OPS received along ICIs, while C did not. primary endpoint was progression-free survival (PFS). secondary outcome measure objective response rate (ORR). Results A total 253 included...
<i>Objective:</i> To investigate whether the peritoneal cavity could function as a bioreactor to produce autologous tubular grafts for ureteral reconstruction in beagles. <i>Materials and Methods:</i> 8-Fr Silastic tubes were implanted into cavities of 6 female At 3 weeks, harvested tissue covering was gently everted. A segment cm length right mid-ureter, involving two thirds its diameter, removed parallel axis, leaving third wall. 5-Fr double-J stent inserted ureter...
Abstract. It is still a severe challenge to optimize the field management practices for multi-crop system when simultaneously aiming at yield sustainability and minimum negative impacts on climate as well atmosphere water quality. This site-scale case study was devoted developing biogeochemical process model-based approach solution this challenge. The best (BMPs) of three-crop growing cotton winter wheat–summer maize (W–M) in rotation, which widely adopted northern China, were identified....
To evaluate the treatment pattern and survival of patients receiving radical resection for primary small cell carcinoma esophagus (PSCCE). This retrospective study included 150 who received PSCCE. Data were retrieved from 4 centers in Western China. Thirty-nine postoperative chemo-radiotherapy, 62 chemotherapy, 49 only. The median radiation dosage was 50 Gy. chemotherapeutic regimen platinum-based lasted 2 to 6 cycles (median, 3). Median disease-free (mDFS) overall (mOS) 12.0 18.3 months,...