A5023146718- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Reproductive biology and impacts on aquatic species
- Aquaculture Nutrition and Growth
- Intraocular Surgery and Lenses
- Bone Metabolism and Diseases
- Ocular Diseases and Behçet’s Syndrome
- Food composition and properties
- Mesenchymal stem cell research
- Pelvic and Acetabular Injuries
- Ocular Infections and Treatments
- Bone fractures and treatments
- Hip and Femur Fractures
- Aquaculture disease management and microbiota
- Circular RNAs in diseases
- Gut microbiota and health
- Glaucoma and retinal disorders
- Ophthalmology and Eye Disorders
- Toxic Organic Pollutants Impact
- Animal Genetics and Reproduction
- Traumatic Ocular and Foreign Body Injuries
- Barrier Structure and Function Studies
- Natural Products and Biological Research
- Coagulation and Flocculation Studies
- Biomarkers in Disease Mechanisms
Ministry of Ecology and Environment
2024-2025
Nanjing Institute of Environmental Sciences
2024-2025
Guangzhou University of Chinese Medicine
2017-2024
Shaoxing People's Hospital
2024
Guangxi University
2024
State Key Laboratory of Pollution Control and Resource Reuse
2023
Nanjing University
2023
The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
2016-2022
Northwest A&F University
2021
South China University of Technology
2019
Although previous studies have confirmed the association between phthalate esters (PAEs) exposure and endocrine disorders in humans, few to date systematically assessed threats of new PAE alternatives disruptions. Herein, zebrafish embryos were continuously exposed two PAEs [di-n-butyl (DBP) diisobutyl (DiBP)], structurally related [diiononyl (DINP) diisononyl hexahydrophthalate (DINCH)], non-PAE substitutes [dipropylene glycol dibenzoate (DGD) glyceryl triacetate (GTA)],...
Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to be used for treatment of delayed union, nonunion or persistent bone defects in MSC‑based cell therapy. However, implantation BMSCs into fracture site is confronted with apoptosis on account harsh conditions and oxidative stress. In present study, anti‑apoptotic effects berberine (BBR) subjected hydrogen peroxide (H2O2) are investigated, underlying mechanisms explored. Oxidative injury was induced by exposure H2O2,...
Nonalcoholic fatty liver disease (NAFLD) is characterized by marked imbalances in lipid storage and metabolism. Because the beneficial health effects of cereal β-glucan (BG) include lowering cholesterol regulating metabolism, BG may alleviate metabolism observed during NAFLD. The aim our study was to investigate whether from highland barley has an effect on western diet-induced NAFLD mice. Using lipidomics, we investigated underlying mechanisms intervention, identified potential biomarkers....
Tetrabromobisphenol A bis (2-hydroxyethyl) ether (TBBPA-DHEE), a derivative of TBBPA, has been frequently detected in the environment. In this study, median lethal concentration (LC50) TBBPA-DHEE at 96 h post-fertilization (hpf) was 1.573 mg/L. Based on reported environmental concentrations, we investigated effects nervous system zebrafish embryos following exposure to varying concentrations (0, 20, 100, and 500 μg/L) for 4 144 hpf. Our results indicated that 100 μg/L hpf led behavioral...
It has been previously reported that psoralen, one of the active ingredients in Psoralea corylifolia, could induce osteogenic differentiation bone marrow mesenchymal stem cells (BMSCs), suggesting its potential to treat osteoporosis. Additionally, runt‑related transcription factor 2 (Runx2) is a plays vital roles BMSC differentiation. However, whether and how microRNAs (miRNAs/miRs) modulate induced by psoralen have not yet examined, best authors' knowledge. The present study aimed identify...
Mesenchymal Stem Cells (MSCs) therapy has become a new coming focus of clinical research in regenerative medicine. However, only small number implanted MSCs could successfully reach the injured areas. The previous studies have shown that fracture healing time is inversely proportional to concentration tissue.The migration and osteogenesis were assessed by transwell assay Alizarin Red S staining. Levels gene protein expression checked qPCR Western Blot. On other hand, enhanced ability induced...
The difficulty in associating diverse pollutants with mixture effects has led to significant challenges identifying toxicants combined pollution. In this study, pathways were used link and toxicants. By evaluated by the concentration-dependent transcriptome, individual extended molecular mechanisms encompassing 135 corresponding 6 biological processes. Accordingly, mechanism-based identification of was achieved constructing a pathway toxicant database containing 2413 chemical–pathway...
Abstract Background The influence of β -glucan on the human gut microbiota is closely related to physicochemical structure -glucan. We purified a homogeneous water-soluble polysaccharide from Tibetan hull-less barley 25 and studied its in vitro fermentation profile. Results Analysis by gas chromatography (GC), Fourier-transformed infrared (FT-IR), nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), atomic force micrograph (AFM) helped determine be (molecular weight: 3.45 ×...
Our previous study showed that (+)-cholesten-3-one (CN) has the potential to induce osteoblastic differentiation of mesenchymal stem cells (MSCs). However, roles CN in targeting miRNA-mRNA-lncRNA interactions regulate osteoblast remain poorly understood.A total 77 miRNAs (36 upregulated and 41 downregulated) 295 lncRNAs (281 14 were significantly differentially expressed during CN-induced MSC osteogenic differentiation. Bioinformatic analysis identified several pathways may play vital...
Bushen Huoxue decoction (BHD) has a significant effect on fracture rehabilitation, yet its underlying mechanism is still unknown. The purpose of this study was to explore whether BHD promotes bone marrow mesenchymal stem cell (BMSC) migration through the Wnt5a signalling pathway. extracted by petroleum, and composition analysed. Cell viability in presence various concentrations for 24, 48 72 h measured using Counting Kit-8 assay. Transwell assays wound healing were used observe ability...
Mesenchymal stem cells (MSCs) can be easily expanded without losing the ability of multilineage differentiation, including oesteogenic, chondrogenic and adipogenic differentiation. These characters make MSCs a promising cell resource for cartilage defect repair. could recruited by inflammatory stimulation, then home to injury tissues. However, its capacity homing is extremely limited. Thus, it has become necessary develop an agent or method, which used enhance efficiency homing. This study...