A5100752000- Extracellular vesicles in disease
- Lymphoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- Silk-based biomaterials and applications
- Genomics, phytochemicals, and oxidative stress
- Advanced Materials and Mechanics
- Galectins and Cancer Biology
- Drug-Induced Hepatotoxicity and Protection
- Ferroptosis and cancer prognosis
- Animal Genetics and Reproduction
- CAR-T cell therapy research
- Long-Term Effects of COVID-19
- Cardiovascular Effects of Exercise
- Single-cell and spatial transcriptomics
- Nanoparticle-Based Drug Delivery
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- DNA Repair Mechanisms
- Eosinophilic Disorders and Syndromes
- Ovarian cancer diagnosis and treatment
- Viral gastroenteritis research and epidemiology
- Inflammation biomarkers and pathways
Shandong University of Technology
2025
Dezhou University
2025
Guangzhou University of Chinese Medicine
2018-2024
Union Hospital
2022-2024
Huazhong University of Science and Technology
2022-2024
China Institute of Sport Science
2022
The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
2018-2021
United States Department of Veterans Affairs
2019
Nanfang Hospital
2018
Southern Medical University
2018
Background/Aims: Circular RNAs (circRNAs) serve as potential diagnostic biomarkers. In this study, we aimed to identify a biomarker from peripheral blood mononuclear cells (PBMCs) of patients with postmenopausal osteoporosis (PMOP). Methods: CircRNA expression in PBMCs three pairs samples PMOP and controls was initially detected by circRNA microarray. The changes selected circRNAs 28 21 age- sex-matched were confirmed using quantitative reverse transcription polymerase chain reaction...
The main diagnostic indicators of ovarian cancer (OC), including carbohydrate antigen 125 (CA125) and human epididymis protein 4 (HE4), show good sensitivity poor specificity or vice versa.This study investigated changes in CA125 HE4 expression their correlation serum-derived exosomes 55 patients with OC (OC group), 33 malignant tumors (non-OC normal controls (NC group).We compared serum exosomal levels to determine whether contents were elevated.We also the efficacy HE4, CA125, HE4+exosomal...
To promote the development of extracellular vesicles herbal medicine especially establishment standardization, led by National Expert Committee on Research and Application Chinese Herbal Vesicles, research experts in field were invited nationwide with support Professional Extracellular Vesicle Application, Society Hospitals Guangdong Engineering Center Vesicles. Based collation relevant literature, we have adopted Delphi method, consensus meeting method combined nominal group to form a...
The practical application of flexible sensors in sound detection is significantly hindered by challenges such as information isolation, fragmentation, and low fidelity. To address these challenges, this work developed a composite hydrogel via one-pot method, employing polyvinyl alcohol (PVA) the first network, polyacrylic acid (PAA) second two-dimensional nanomaterials—reduced graphene oxide (rGO)—generated through redox reaction polydopamine (PDA) (GO) conductive fillers. uniformly...
Mesenchymal Stem Cells (MSCs) therapy has become a new coming focus of clinical research in regenerative medicine. However, only small number implanted MSCs could successfully reach the injured areas. The previous studies have shown that fracture healing time is inversely proportional to concentration tissue.The migration and osteogenesis were assessed by transwell assay Alizarin Red S staining. Levels gene protein expression checked qPCR Western Blot. On other hand, enhanced ability induced...
Abstract Background Evidence has demonstrated that monitoring of the variable, diversity, and joining gene segments (VDJ) rearrangement immunoglobulin (Ig) genes in circulating tumor DNA (ctDNA) is value predicting outcomes diffuse large B cell lymphoma (DLBCL). In this study, we investigated role VDJ proportion ctDNA for DLBCL progression. Methods Patients diagnosed with newly were included study. The sequences IgH detected using next-generation sequencing (NGS) formalin-fixed...
Circular RNAs (circRNAs) are emerging as important regulators in bone metabolism, which is mediated by microRNA (miRNA) sponges. However, it not clear how circRNA regulates osteogenic differentiation of human marrow mesenchymal stem cells (hBM-MSCs).Therefore, based on the previous chip results, hsa_circ_0006766, differentially expressed hBM-MSCs, was screened out, and bioinformatics analysis performed to predict potential target miRNAs. During hsa_circ_0006766 its miRNAs (miR-4739,...
Plant-derived nanovesicles (NVs) and extracellular vesicles (EVs) are the next generation of nanocarrier platforms for biotherapeutics drug delivery. EVs exist not only in space, but also within cell wall. Due to limitations existing isolation methods, extraction efficiency is low, a large amount plant material wasted, which concern rare expensive medicinal plants. We proposed validated novel method by enzyme degradation wall release EVs. The released can easily be collected. new was used...
Relapsed and refractory diffuse large B-cell lymphoma (DLBCL) is associated with poor prognosis. As such, a comprehensive analysis of intratumoral components, heterogeneity, the immune microenvironment essential to elucidate mechanisms driving progression DLBCL develop new therapeutics. Here, we used single-cell transcriptome sequencing conventional bulk next-generation (NGS) understand composite tumor landscape single patient who had experienced multiple recurrences following several...
Background. Myocardial infarction (MI) is cardiac tissue necrosis caused by acute and persistent ischemic hypoxia of the coronary arteries. This study aimed at investigating expression long noncoding RNA (lncRNA) LINC00261 in MI its effect on myocardial cells. Methods. qRT-PCR was performed to detect levels LINC00261, miR-522-3p, TNRC6A normal Western blotting analysis protein. Viability apoptosis cells after with knockout or were detected. The relationships among cardiomyocytes evaluated...
Abstract Background Postmenopausal osteoporosis (PMOP) is an estrogen deficiency‐induced skeletal disorder. Bone mineral density (BMD) testing the gold standard for diagnosing osteoporosis. However, its sensitivity fracture risk assessment low. Programmed cell death protein 1 (PD‐1) a key immune checkpoint molecule implicated in pathophysiology of bone remodeling, but role has not yet been explored. Thus, this study aimed to assess expression and diagnostic utility PD‐1 PMOP. Methods A total...
The synergistic disruption of intracellular redox homeostasis through the combination ferroptosis/gas therapy shows promise in enhancing antitumor efficacy. However, development an optimal delivery system encounters significant challenges, including effective storage, precise delivery, and controlled release therapeutic gas. In this study, we propose utilization a disruptor that is selectively activated by tumor microenvironment (TME), conjunction with our newly developed nanoplatforms...
Abstract There is currently a lack of biomarkers to assist the diagnosis and prediction primary gouty arthritis (PG). Therefore, we evaluated clinical value programmed cell death protein 1 (PD‐1) mRNA expression in peripheral blood mononuclear cells (PBMCs) patients with PG. This study included 36 acute phase PG (APPG), 48 non‐acute (NAPPG), 42 asymptomatic hyperuricemia (AH) 79 normal controls (NCs). PD‐1 levels were detected by qRT‐PCR. was statistically analysed ANOVA or t tests, while...
Background Pituitary metastasis accounts for a very low percentage of cases brain from lung cancer, and there are uncertainties challenges in diagnosis treatment. We hope to shed some light on the treatment by reporting case ALK fusion mutation-positive cancer pituitary metastasis. Case presentation report 48-year-old female patient with an initial stage IVB adenocarcinoma fusion. The developed headache, dizziness, hypopituitarism hyperprolactinemia one year after crizotinib. Later,...
PURPOSE: Previous studies on the effects of training pre-adolescent hearts have given inconsistent findings likely due to load dependency conventional parameters characterize left ventricular function. Pressure-strain loop (PSL) analysis provides a novel less load-dependent non-invasive method quantify myocardial work. We aim apply PSL in young athletes test whether LV functional change was related and body growth. METHODS: Cardiac morphology function 20 basketball players were assessed at...
Exosomes are vesicle-like bodies of that actively secreted by cells to the extracellular surrounding with a diameter 40–100 nm. They have several physiological functions, such as cell-cell communication, antitumor immunity, and angiogenesis promotion. many important roles extensively distributed in various fluids throughout body, therefore, they significant interest researchers diverse fields. Based on characteristics functions exosomes, this review summarizes research progression regarding...
ABSTRACT Plant-derived nanovesicles (NVs) and extracellular vesicles (EVs) are considered to be the next generation of nanocarrier platforms for biotherapeutics drug delivery. However, EVs exist not only in space, but also within cell wall. Due limitation isolation methods, extraction efficiency is low, resulting waste a large number plants, especially rare expensive medicinal plants.There few studies comparing NVs. To overcome these challenges, we proposed validated novel method plant by...