A5100347235- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Pickering emulsions and particle stabilization
- Viral Infections and Vectors
- Cancer Research and Treatments
- Genetics and Neurodevelopmental Disorders
- PARP inhibition in cancer therapy
- Neuroendocrine Tumor Research Advances
- Vascular Tumors and Angiosarcomas
- Lung Cancer Research Studies
- Autoimmune Neurological Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- Lattice Boltzmann Simulation Studies
- Solar-Powered Water Purification Methods
- Antioxidant Activity and Oxidative Stress
- Hemodynamic Monitoring and Therapy
- Hydrogels: synthesis, properties, applications
- Photoacoustic and Ultrasonic Imaging
- Thermal properties of materials
- Renal and related cancers
Tianjin Medical University Cancer Institute and Hospital
2006-2025
Southern Medical University
2016-2024
Zhujiang Hospital
2004-2023
Sichuan University
2022
Chengdu University
2022
Chongqing Cancer Hospital
2021
Chongqing University
2021
Shanghai Jiao Tong University
2008
Existing nanoparticle-mediated drug delivery systems for glioma systemic chemotherapy remain a great challenge due to poor efficiency resulting from the blood brain barrier/blood-(brain tumor) barrier (BBB/BBTB) and insufficient tumor penetration. Here, we demonstrate distinct design by patching doxorubicin-loaded heparin-based nanoparticles (DNs) onto surface of natural grapefruit extracellular vesicles (EVs), fabricate biomimetic EV-DNs, achieving efficient thus significantly enhancing...
Abstract Multidrug resistance remains a great challenge for cancer chemotherapy. Herein, biomimetic drug delivery system based on lemon‐derived extracellular vesicles (EVs) nanodrugs (marked with heparin‐cRGD‐EVs‐doxorubicin (HRED)) is demonstrated, achieving highly efficient overcoming multidrug resistance. The HRED fabricated by modifying functional heparin‐cRGD (HR) onto the surface of EVs and then loading doxorubicin (DOX). obtained enable to effectively enter DOX‐resistant cells...
Abstract Existing solid‐nanoparticle‐based drug delivery systems remain a great challenge for glioblastoma chemotherapy due to their poor capacities in crossing the blood–brain barrier/blood–brain tumor barrier (BBB/BBTB). Herein, fruit‐derived extracellular‐vesicle (EV)‐engineered structural droplet drugs (ESDDs) are demonstrated by programming self‐assembly of EVs at DOX@squalene–PBS interface, greatly enhancing antitumor efficacy against glioblastoma. The ESDDs experience flexible via...
Extracellular vesicles (EVs) have recently received much attention about the application of drug carriers due to their desirable properties such as nano-size, biocompatibility, and high stability. Herein, we demonstrate orange-derived extracellular (OEV) nanodrugs (DN@OEV) by modifying cRGD-targeted doxorubicin (DOX) nanoparticles (DN) onto surface OEV, enabling significantly enhancing tumor accumulation penetration, thereby efficiently inhibiting growth ovarian cancer. The obtained DN@OEV...
Solid nanoparticle-mediated drug delivery systems are usually confined to nanoscale due the enhanced permeability and retention effect. However, they remain a great challenge for malignant glioma chemotherapy because of poor efficiency insufficient tumor penetration resulting from blood-brain barrier/blood-brain barrier (BBB/BBTB). Inspired by biological microparticles (e.g., cells) with excellent adaptive deformation, it is demonstrated that microdrugs (even up 3.0 µm in size) more...
To promote the development of extracellular vesicles herbal medicine especially establishment standardization, led by National Expert Committee on Research and Application Chinese Herbal Vesicles, research experts in field were invited nationwide with support Professional Extracellular Vesicle Application, Society Hospitals Guangdong Engineering Center Vesicles. Based collation relevant literature, we have adopted Delphi method, consensus meeting method combined nominal group to form a...
The systemic inflammatory response index (SIRI), a novel inflammation maker, has proven to be associated with prognostic outcomes in various diseases. However, few studies have been conducted assessing how SIRI may influence of patients on peritoneal dialysis (PD). Herein, we assessed the predictive value mortality all-cause mortality, including cardiovascular disease (CVD) PD patients.
Vasculogenic minicry (VM), an alternative blood supply modality except to endothelial cells-mediated vascular network, is a potential therapeutic target for ovarian cancer due VM correlated with poor prognosis in patients. Accelerated extracellular matrix (ECM) degradation prerequisite formation induced by epithelial-mesenchymal transition (EMT). Previous reports demonstrate uPA has ability degrade ECM thereby promoting tumor angiogenesis. Also, exogenous cRGD sequence enables modulate...
Abstract Background Nuclear expression of CTNNB1 is occasionally negative in solid‐pseudopapillary neoplasm (SPN) the pancreas, leading to a missed diagnosis. In present study, we aimed investigate clinical significance mutation detection for diagnosing SPN and explore difference clinicopathological characteristics at different ages sex. Methods Patients who underwent surgery pathologically confirmed our institution between 2011 2020 were collected. Their data analyzed. Results The median...
Background: Non-small cell lung cancer (NSCLC) is the most commonly diagnosed solid tumor. While it has been established that stereotactic body radiotherapy for NSCLC plays an important role in antitumor immune response, possible effects of dose rate on this response not fully clarified.Methods: In vitro, A549 cells were irradiated a Varian TrueBeam® Linear Accelerator with and escalation using flattening filter-free (FFF) technique, which was followed by coculturing peripheral blood...
Beyond traditional endothelium-dependent vessel (EDV), vascular mimicry (VM) is another critical tumor angiogenesis that further forms in many malignant metastatic tumors. However, the existing anti-angiogenesis combined chemotherapeutics strategies are only efficient for treatment of EDV-based subcutaneous tumors, but remain a great challenge situ associated with EDV and VM. Here, we demonstrate self-assembled nanoparticle (VE-DDP-Pro) featuring self-anti-EDV -VM capacity enables to...
Objective. To study the clinical characteristics and surgical outcomes of anti-NMDAR encephalitis immunopathology associated teratomas. Methods. Twenty-one patients were enrolled in this retrospective study, who diagnosed with ovarian teratoma admitted to two tertiary hospitals South China from July 2014 December 2019. The data reviewed. Comparisons made between different after surgery. Immunohistochemical analyses teratomas performed. Results. mean age was <math...
Abstract Owing to low drug delivery efficiency (<1%), nanoparticle‐based system remains great challenge for efficient tumor chemotherapeutics. In this study, bioinspired coordination‐assembled nanoparticles (CuET@HR‐Pro) are fabricated by programming the assembly of three types functional biomolecules (heparin, cRGD, and protamine) anti‐cancer (CuET). The enhanced an intravenous injective dose up 6.9%, thereby significantly improving anti‐tumor efficacy drug. CuET@HR‐Pro is patching...
The single-walled carbon nanotubes (SWNTs) were randomly deposited on pre-treated silicon substrate by a self-assembling method. By this method, the SWNTs film with uniform distribution and random structure formed density of could be controlled concentration suspension assembling time. Also, Cr interdigitated electrodes patterned assembled traditional lift-off process. results show that films made self-assembly can adhere firmly to substrate.