A5080333757- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Plant Molecular Biology Research
- Lung Cancer Treatments and Mutations
- Plant nutrient uptake and metabolism
- Viral-associated cancers and disorders
- Legume Nitrogen Fixing Symbiosis
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Photosynthetic Processes and Mechanisms
- Genomics and Phylogenetic Studies
- Multiple Myeloma Research and Treatments
China Agricultural University
2023-2025
Health Biomed (China)
2022
Plants generally enhance their root growth in the form of greater biomass and/or length to boost nutrient uptake response short-term low nitrogen (LN). However, underlying mechanisms LN-mediated remain largely elusive. Our genome-wide association study, haplotype analysis, and phenotyping transgenic plants showed that crucial nitrate signaling component NIN-LIKE PROTEIN3.2 (ZmNLP3.2), a positive regulator biomass, is associated with natural variations maize (Zea mays L.) seedlings under LN....
Abstract Background Evidence has demonstrated that monitoring of the variable, diversity, and joining gene segments (VDJ) rearrangement immunoglobulin (Ig) genes in circulating tumor DNA (ctDNA) is value predicting outcomes diffuse large B cell lymphoma (DLBCL). In this study, we investigated role VDJ proportion ctDNA for DLBCL progression. Methods Patients diagnosed with newly were included study. The sequences IgH detected using next-generation sequencing (NGS) formalin-fixed...
Abstract Purposes Evidence has demonstrated that monitoring of the variable, diversity, and joining gene segments (VDJ) rearrangement immunoglobulin (Ig) in circulating tumor DNA (ctDNA) is highly valuable predicting prognosis patients with diffuse large B cell lymphoma (DLBCL). In this study, we investigated role both Ig heavy chain (IGH) kappa light (IGK) rearrangements detected ctDNA samples DLBCL progression. Methods Next-generation sequencing (NGS) was used to identify dominant V(D)J...
SUMMARY As a maternal tissue, the pericarp supports and protects for other components of seed, such as embryo endosperm. Despite importance maize in genome‐wide transcriptome pattern throughout development has not been well characterized. Here, we developed RNA‐seq atlas B73 based on 21 samples from 5 days before fertilization (DBP5) to 32 after (DAP32). A total 25 346 genes were detected programming development, including 1887 transcription factors (TFs). Together with morphological...
Diagnosis classification and risk stratification are crucial in the prognosis prediction treatment selection of acute myeloid leukemia (AML). Here, we used a database 536 AML patients to compare 4th 5th WHO classifications 2017 2022 versions ELN guidance.AML were classified according classifications, as well European LeukemiaNet (ELN) guidance. Kaplan-Meier curves with log-rank tests for survival analysis.The biggest change was that 25 (5.2%), 8 (1.6%), 1 (0.2%) AML, not otherwise specified...
Characterization of gene mutation profiles can provide new treatment options for patients with diffuse large B-cell lymphoma (DLBCL). However, this method is challenged by the limited source tissue specimens, especially those DLBCL at advanced stages. Therefore, in current study, we aimed to describe landscape using circulating tumor DNA (ctDNA) samples obtained from patients' blood samples, as well explore relationship between ctDNA mutations and prognosis response newly diagnosed DLBCL.A...
Purposes Osimertinib, one of the third-generation EGFR -tyrosine kinase inhibitors (TKIs) designed to target T790M mutation, significantly improves prognosis lung cancer. However, drug resistance still happens and MET amplification is responsible for main causes. Fluorescence in situ hybridization (FISH) gold standard detection, but fundamentally limited by observer subjectivity. Herein, we assessed value next-generation sequencing (NGS) method detection non-small cell cancer (NSCLC), as...