A5102017428- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Bone health and treatments
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Bone fractures and treatments
- Medicinal Plant Pharmacodynamics Research
- Immune cells in cancer
- Fibroblast Growth Factor Research
- Mesenchymal stem cell research
- Gut microbiota and health
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Signaling Pathways in Disease
- Kruppel-like factors research
- Otolaryngology and Infectious Diseases
- Connective Tissue Growth Factor Research
- Scoliosis diagnosis and treatment
- Phytochemical and Pharmacological Studies
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Hip and Femur Fractures
- TGF-β signaling in diseases
- Environmental Changes in China
- Effects of Radiation Exposure
China Medical University
2024
Xijing Hospital
2023
Guangxi Academy of Special Crops
2023
Chinese Academy of Sciences
2023
Air Force Medical University
2014-2023
Foshan Second People's Hospital
2022-2023
Henan University Huaihe Hospital and Huaihe Clinical Institute
2023
Shandong University of Traditional Chinese Medicine
2023
Guangxi Institute of Botany
2023
First Affiliated Hospital of Xiamen University
2022
Autoimmune diseases such as ankylosing spondylitis (AS) can be driven by emerging neoantigens that disrupt immune tolerance. Here, we developed a workflow to profile posttranslational modifications involved in neoantigen formation. Using mass spectrometry, identified panel of cysteine residues differentially modified carboxyethylation required 3-hydroxypropionic acid generate patients with AS. The lysosomal degradation integrin αIIb [ITGA2B (CD41)] carboxyethylated at Cys96 (ITGA2B-ceC96)...
Purpose: A key factor in regulating bone absorption is the proportion of RANKL/OPG. Although many reports showing diverse transcription factors or epigenetic modification could be responsible for RANKL&OPG ratio, there still little exploration on promoter methylation status both genes osteoporotic tissues. Our aim to investigate changes CpG island these genes' promoters patients with primary osteoporosis. Methods: The diagnosis osteoporosis was based results dual energy X-ray absorptiometry...
Radiation-induced cardiopulmonary injuries are the most common and intractable side effects that entwined with radiotherapy for thorax cancers. However, therapeutic options such complications have yielded disappointing results in clinical applications. Here, we reported gut microbiota-derived l-Histidine its secondary metabolite imidazole propionate (ImP) fought against radiation-induced injury an entiric flora-dependent manner mouse models. Local chest irradiation decreased level of fecal...
As a surface glycoprotein, CD147 is capable of stimulating the production matrix metalloproteinases (MMPs) from neighboring fibroblasts. The aim present study to explore role soluble on MMPs secretion hepatocellular carcinoma (HCC) cells, and investigate diagnostic value serum in HCC detection. We identified form cell culture supernate cells patients with HCC, explored secretion. Serum levels were detected by enzyme-linked immunosorbent assay, as marker detection was analyzed. Full length...
Problem Estradiol (E2) deficiency can cause bone loss and the skew of Th1/Th2 cells. However, correlation between cells induced by estrogen remains unclear. Our aim was to investigate role in elucidated therapeutical effect catalpol this condition. Method Study Young, sham-operated (Sham), ovariectomized (Ovx), naturally aged mice, treated with at different doses or control vehicle, were used study as indicated each experiment. ELISA assay, dual-energy X-ray absorptiometry, flow cytometry...
Purpose . SOST gene is one of the key factors in regulating bone absorption. Although there are reports showing diverse transcription factors, epigenetic modification could be responsible for expression. There still little exploration on promoter methylation status osteoporotic tissues. The aim this study to investigate involvement CpG regulation expression patients with primary osteoporosis. Methods diagnosis osteoporosis was established basis dual energy X-ray absorptiometry measure BMD....
Icaritin, a metabolite of icariin, is potent promoter bone marrow‑derived mesenchymal stem cells (BMSCs) osteogenesis, but the underlying mechanisms remain unclear. To examine effects icaritin on osteogenic differentiation, BMSCs were exposed to induction medium with or without pretreatment in present study. It was identified that (0.01‑1 µM) exhibited no cytotoxicity proliferative abilities BMSCs. Icaritin at 1 µM increased alkaline phosphatase activity, mineral deposition and...
Abstract Problem Postmenopausal osteoporosis (PMO) is a common osteoporosis. Hyperoside (Hyp), natural flavonoid compound, has anti‐osteoporotic effects, but the underlying mechanisms remain poorly understood. Inflammatory cytokine IL‐17A upregulated in PMO and plays vital roles bone loss, upstream regulatory factors are still unknown. Method of study Twenty patients 20 healthy control subjects were included to analyze expression changes screen dys‐regulated miRNAs peripheral blood patients....
Refractory femoral neck fractures cannot be anatomically reduced by closed traction reduction which may affect fracture healing. We evaluated the biomechanical effects of positive, negative, and anatomic various degrees displacement in Pauwels I a finite element analysis.Five models type were established using Mimics 17.0 (Materialize, Leuven, Belgia) Hypermesh 12.0 (Altair Engineering, Troy, MI, USA). According to degree displacement, there three positive support, an model, negative 2 mm...
Bushen Huoxue decoction (BHD) has a significant effect on fracture rehabilitation, yet its underlying mechanism is still unknown. The purpose of this study was to explore whether BHD promotes bone marrow mesenchymal stem cell (BMSC) migration through the Wnt5a signalling pathway. extracted by petroleum, and composition analysed. Cell viability in presence various concentrations for 24, 48 72 h measured using Counting Kit-8 assay. Transwell assays wound healing were used observe ability...
Abstract Background Airway management, including noninvasive endotracheal intubation or invasive tracheostomy, is an essential treatment strategy for patients with deep neck space abscess (DNSA) to reverse acute hypoxia, which aids in avoiding cerebral hypoxia and cardiac arrest. This study aimed develop validate a novel risk score predict the need airway management DNSA. Methods Patients DNSA admitted 9 hospitals Guangdong Province between January 1, 2015, December 31, 2020, were included....
HELLP syndrome is a combination of symptoms described as hemolysis, elevated liver enzymes and low platelets. common life-threatening complication pregnancy thought to be variant or preeclampsia. In this case report, we aimed present woman with acute postpartum complicated by pulmonary edema after caesarean section following severe Our experience suggests that early detection timely management will bring good outcomes.
In the present study, promoter hypermethylation of cysteine dioxygenase type 1 (CDO1) was evaluated in non-small cell lung cancer (NSCLC) tissues to assess value CDO1 as a novel biomarker improve diagnosis NSCLC. Tumor tissue samples and corresponding normal from 42 patients with NSCLC were obtained at Department Thoracic Surgery, The Second Xiangya Hospital (Changsha, China). Conventional methylation-specific PCR (cMSP) methylation-on-beads followed by quantitative (MOB-qMSP) used analyze...
Objective. The classical osteoporotic signaling pathways include the four key genes (LRP5, Runx2, Osterix, and RANKL) influencing regulation of osteogenesis osteoclastogenesis. This study investigates expression these associated with bone remodeling during fracture healing. Methods. Ovariectomized rats as an group were randomly divided into three groups-group A, B, C. Nonosteoporotic control likewise groups A0, B0, C0, using same method. killed on third day fractures in A seventh B...
Aims: Mineral elements are important determinants of soil nutrients and related to forest community composition nutrient cycling.There is high terrain heterogeneity in karst seasonal rainforest local scale, but there still lack research on how other abiotic biotic factors affect the spatial distribution mineral inkarst area.Methods: In this study, we set up 100 litter fall traps along elevation gradient 15 ha northern tropical dynamics plot Nonggang, southwestern Guangxi, conducted sampling...