A5100972039- Cancer-related gene regulation
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Head and Neck Cancer Studies
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- Wnt/β-catenin signaling in development and cancer
- Electrospun Nanofibers in Biomedical Applications
- Pluripotent Stem Cells Research
- Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Erythrocyte Function and Pathophysiology
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Cell death mechanisms and regulation
- Liver physiology and pathology
- Platelet Disorders and Treatments
- Bone Tissue Engineering Materials
- Salivary Gland Tumors Diagnosis and Treatment
- DNA Repair Mechanisms
- Signaling Pathways in Disease
Guangxi University
2023-2025
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2024-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2015-2025
Chongqing Medical University
2010-2025
Center for High Pressure Science & Technology Advanced Research
2015-2024
Beijing Radiation Center
2022-2024
Georgia Institute of Technology
2024
Guangzhou Institutes of Biomedicine and Health
2022-2023
Shenzhen Institutes of Advanced Technology
2022
Chinese Academy of Sciences
2022
Cancer-associated mesenchymal stem cells (MSCs) play a pivotal role in modulating tumor progression. However, the interactions between liver cancer-associated MSCs (LC-MSCs) and hepatocellular carcinoma (HCC) remain unreported. Here, we identified presence of HCC tissues. We also showed that LC-MSCs significantly enhanced growth vivo promoted sphere formation vitro. metastasis an orthotopic transplantation model. Complementary DNA (cDNA) microarray analysis S100A4 expression was higher...
Abnormal activation of the Sonic hedgehog (SHH) pathway has been described in a wide variety human cancers and cancer stem cells (CSCs), however, role SHH gastric CSCs not reported. In this study, we investigated possibility that abnormal maintained characteristics CSCs. First, identified stem-like (CSLCs) from cell lines (HGC-27, MGC-803 MKN-45) using tumorsphere culture. Compared with adherent cells, floating had more self-renewing capacity chemoresistance. The expressing markers (CD44,...
Up to now, the gingiva-derived mesenchymal stem cells (GMSCs) as a new postnatal have been isolated and characterized with multipotential differentiation capabilities in vitro. However, vivo efficacy of utilizing GMSCs bone regeneration remains obscure. First all, we identified canonical MSCs human gingival tissue, which possessed homogenous immunophenotype (CD34−CD45−CD29+CD105+CD90+ STRO-1+) had tri-lineage potential (osteoblasts, adipocytes, chondrocytes). Next, examined these tissue...
Emerging evidence suggests that epithelial‐mesenchymal transitions (EMTs) play important roles in tumor metastasis and recurrence. Understanding molecular mechanisms regulate the EMT process is crucial for improving treatment of hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) HCC; however, by which miRNAs target their therapeutic potential remains largely unknown. To better explore process, we established an model HCC cells transforming growth factor beta 1 found several tumor‐related...
Stem cells have emerged as a potential therapy for range of neural insults, but their application in Alzheimer's disease (AD) is still limited and the mechanisms underlying cognitive benefits stem remain to be elucidated. Here, effects clinical-grade human umbilical cord-derived mesenchymal (hUC-MSCs) on recovery ability SAMP8 mice, senescence-accelerated mouse model AD explored. A functional assay identifies that core factor hepatocyte growth (HGF) secreted from hUC-MSCs plays critical...
Abstract Thrombosis leads to platelet activation and subsequent degradation; therefore, replenishment of platelets from hematopoietic stem/progenitor cells (HSPCs) is needed maintain the physiological level circulating platelets. Platelet-derived microparticles (PMPs) are protein- RNA-containing vesicles released activated We hypothesized that factors carried by PMPs might influence production HSPCs, in a positive feedback fashion. Here we show that, during mouse acute liver injury, density...
Rescuing or compensating mitochondrial function represents a promising therapeutic avenue for radiation-induced chronic wounds. Adult stem cell efficacies are primarily dependent on the paracrine secretion of mitochondria-containing extracellular vesicles (EVs). However, effective strategies addressing quantity mitochondria and mitochondria-delivery system lacking. Thus, in this study, we aimed to design an hydrogel microneedle patch (MNP) loaded with cell-derived mitochondria-rich EVs...
The high incidence rate of hepatocellular carcinoma (HCC) is mainly the result frequent metastasis and tumor recurrence. Unfortunately, underlying molecular mechanisms driving HCC are still not fully understood. It has been demonstrated that stroma cells contribute to primary growth metastasis. Within environment, activated hepatic stellate (HSCs) can release a number molecules enhance cancer cell proliferation invasiveness in paracrine manner. Here, for first time, we demonstrate epimorphin...
Abstract Hepatocellular carcinoma (HCC) has a high mortality rate due to the lack of effective treatments and drugs. Arsenic trioxide (ATO), which been proved successfully treat acute promyelocytic leukemia (APL), was recently reported show therapeutic potential in solid tumors including HCC. However, its anticancer mechanisms HCC still need further investigation. In this study, we demonstrated that ATO inhibits tumorigenesis distant metastasis mouse models, corresponding with prolonged mice...
SPINDLIN1, a new member of the SPIN/SSTY gene family, was first identified as highly expressed in ovarian cancer cells. We have previously shown that it is involved process spindle organization and chromosomal stability plays role development cancer. Nevertheless, mechanisms underlying its oncogenic are still largely unknown. Here, we showed expression SPINDLIN1 upregulated clinical tumors. Ectopic promoted cell proliferation activated WNT/T-cell factor (TCF)-4 signaling. The Ser84 Ser99...
Biological scaffolds based stem cell delivery methods have emerged as a promising approach for tissue repair and regeneration. Here we developed hydrogel biological scaffold from human decellularized adipose matrix (hDAM) adipose-derived cells (hASCs) to accelerate chronic wound healing. The hDAM was prepared by pepsin mediated digestion pH controlled neutralization. morphology, survival, proliferation, angiogenic paracrine activity of hASCs cultured in the were assessed. Moreover,...
Fusarium sacchari is a causal agent of sugarcane Pokkah boeng, an important fungal disease that causes considerable reduction in yield and sugar content susceptible varieties worldwide. Despite its importance, the factors regulate virulence this pathogen remain largely unknown. In our previous study, mapping insertional mutant defect resulted identification cutinase G-box binding protein gene, designated FsCGBP, encodes C2H2-type transcription factor (TF). FsCGBP was shown to localize...
Objective:To investigate optimal treatment strategy for pT3N0 laryngeal squamous cell carcinoma（SCC）. Methods:A retrospective study of 150 patients with SCC treated in the First Affiliated Hospital Chongqing Medical University was performed. The efficacies partial laryngectomy and total laryngectomy, as well surgery alone postoperative radiotherapy were evaluated. overall survival（OS）, disease specific survival（DSS） disease-free survival（DFS） analyzed statistical package from SPSS....
Fusarium sacchari is one of the primary causal agents Pokkah boeng disease (PBD), an important sugarcane worldwide. The acyl-CoA dehydrogenases (ACADs) constitute a family flavoenzymes involved in β-oxidation fatty acids and amino acid catabolism mitochondria. However, role ACADs pathogenesis F. unclear. Here, 14 ACAD-encoding genes (FsACAD-1–FsACAD-14) were identified by screening entire genome sequence sacchari. FsACAD are distributed across seven chromosomes classified into clades based...
Cognitive aging is a leading public health concern with the increasing population, but there still lack of specific interventions directed against it. Recent studies have shown that cognitive function intimately affected by systemic milieu in brain, and improvement environment brain may be promising approach for rejuvenating aging. Here, we sought to study intervention effects clinical-grade human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) on murine model The conventional mice...
Cancer stem cells (CSCs) are reported to play essential roles in chemoresistance and metastasis. Pathways regulating CSC self-renewal proliferation, such as Hedgehog, Notch, Wnt/β-catenin, TGF-β, Myc, may be potential therapeutic targets. Here, a functional screening from the focused library with 365 compounds is performed by step-by-step strategy. Among these candidate molecules, phenyl-2-pyrimidinyl ketone 4-allyl-3-amino selenourea (CU27) chosen for further identification because it...
ABSTRACT Genetic alterations of 13q21 ( PCDH 8,9,17 , and 20 ) are frequently observed in multiple tumors, suggesting the presence critical tumor suppressor genes (TSGs). P rotocadherin20 PCDH20 ), located at 13q21.2, belongs to δ1‐protocadherins, which constitutes one largest subgroup within adherin superfamily. Frequent downregulation/silencing was found NPC cell lines using semiquantitative PCR. mRNA broadly expressed normal nasopharyngeal tissues lines. Promoter methylation 80% (4/5)...
The enzymatic activities of Furin, Transmembrane serine proteinase 2 (TMPRSS2), Cathepsin L (CTSL), and Angiotensin-converting enzyme (ACE2) receptor binding are necessary for the entry coronaviruses into host cells. Precise inhibition these key proteases in ACE2
Protocadherin8 (PCDH8), an integral membrane protein, was reported to be a tumor suppressor involved in tumorigenesis cancers. We aimed investigate the epigenetic inactivation of PCDH8 and its tumor-suppressor function nasopharyngeal carcinoma (NPC). Frequent downregulation/silencing found NPC cell lines using semiquantitative PCR. Promoter methylation observed 100% (5/5) 85.3% (35/41) primary tumors by methylation-specific PCR, but not normal tissues. Treatment cells with...