A5014711277- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Helicobacter pylori-related gastroenterology studies
- Cancer-related gene regulation
- Ovarian cancer diagnosis and treatment
- Wnt/β-catenin signaling in development and cancer
- Cancer Research and Treatments
- Hedgehog Signaling Pathway Studies
- Cancer, Lipids, and Metabolism
- Sarcoma Diagnosis and Treatment
- Enhanced Recovery After Surgery
- Cancer, Stress, Anesthesia, and Immune Response
- Angiogenesis and VEGF in Cancer
- Esophageal Cancer Research and Treatment
Chinese PLA General Hospital
2016-2025
Naval Academy
2025
Dalian Naval Academy
2025
Sun Yat-sen University
2010-2024
Nankai University
2020-2024
Third Affiliated Hospital of Sun Yat-sen University
2010-2024
West China Hospital of Sichuan University
2024
Sichuan University
2024
Ningxia Medical University
2024
Chinese People's Liberation Army
2012-2023
Long non-coding RNAs (lncRNAs) can serve as blood-based biomarkers for cancer detection.To identify novel lncRNA gastric (GC), we conducted, the first time, genome-wide screening analysis in two sets of samples: five paired preoperative and postoperative day 14 plasma samples from GC patients, tissue tumor adjacent normal tissues.Candidate tumor-related lncRNAs were then quantitated evaluated three independent phases comprising 321 participants.The expression levels also measured cell lines...
Abnormal activation of the Sonic hedgehog (SHH) pathway has been described in a wide variety human cancers and cancer stem cells (CSCs), however, role SHH gastric CSCs not reported. In this study, we investigated possibility that abnormal maintained characteristics CSCs. First, identified stem-like (CSLCs) from cell lines (HGC-27, MGC-803 MKN-45) using tumorsphere culture. Compared with adherent cells, floating had more self-renewing capacity chemoresistance. The expressing markers (CD44,...
Abstract Background Stress, anxiety and depression can cause complex physiological neuroendocrine changes, resulting in increased level of stress related hormone catecholamine, which may constitute a primary mechanism by factors impact gene expression tumors. In the present study, we investigated effects catecholamine stimulation on MMP-7 gastric cancer cells elucidated molecular mechanisms up-regulation through an adrenergic signaling pathway. Results Increased was identified at both mRNA...
Abstract The prognosis of gastric cancer remains poor due to clinical drug resistance. Novel drugs are urgently needed. Shikonin (SHK), a natural naphthoquinone, has been reported trigger cell death and overcome resistance in anti-tumour therapy. In this study, we investigated the effectiveness molecular mechanisms SHK treatment with cancer. vitro , suppresses proliferation triggers cells but leads minor damage epithelial cells. induces generation intracellular reactive oxygen species (ROS),...
Abstract Purpose: Ovarian cancer represents a major clinical hurdle for immune checkpoint blockade (ICB), with reported low patient response rates. We found that the ligand PD-L2 is robustly expressed in samples of ovarian cancers and other malignancies exhibiting suboptimal to ICB but not are sensitive. Therefore, we hypothesize can facilitate escape from through incomplete PD-1 signaling pathway. Experimental Design: engineered soluble form receptor (sPD-1) capable binding neutralizing...
Accumulating evidence has proved the close association between alterations in gut microbiota and resistance to chemotherapeutic drugs. However, potential roles of regulating oxaliplatin sensitivity gastric cancer (GC) have not been investigated before. We first found that antibiotic treatment diminished therapeutic efficacy a GC mouse model. Importantly, this effect could be transmitted germ-free mice via fecal transplantation, indicating role modulation efficacy. Further, metagenomics data...
Background Overall, gastric cancer prognosis remains poor. Detailed characterization of molecular markers that govern pathogenesis is warranted to establish innovative therapeutic options. HIF-1α overexpression has been linked poor prognosis. However, though researched for years, the prognostic role in still controversial. Hence, objective present study was analyze values HIF-1α, TGF-β, VEGF and pERK1/2 patients following gastrectomy. Methods This included 446 with confirmed who underwent...
Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5), which is identified as a novel intestinal stem cell marker, overexpressed in various tumours. In this study, we explore Lgr5 expression gastric carcinoma and analyse its role invasion, metastasis, prognosis carcinoma. A combination of immunohistochemistry, western blotting, quantitative reverse transcription–polymerase chain reaction were used to detect mRNA protein levels matrix metalloproteinase 2 (MMP2). Small interfering...
// Yanan Zhang 1, 2 , Jie Liu 1 Jing Lin 3 Lei Zhou 4 Yuhua Song 5 Bo Wei 6 Xiaoli Luo Zhida Chen Yingjie Jiaxiu Xiong Xiaojie Xu Lihua Ding Qinong Ye Department of Medical Molecular Biology, Beijing Institute Biotechnology, Collaborative Innovation Center for Cancer Medicine, Beijing, People's Republic China Stem Cell, Center, Dalian University, Liaoning, First Affiliated Hospital, Chinese PLA General Shijitan Capital The Hospital Qing Dao Qingdao, Surgery, Correspondence to: Ye, e-mail:...
// Wenquan Liang 1, 2, * , Jianxin Cui Kecheng Zhang Hongqing Xi 2 Aizhen Cai 1 Jiyang Li Yunhe Gao Chong Hu Yi Liu Yixun Lu Ning Wang Xiaosong Wu Bo Wei and Lin Chen Department of General Surgery, Chinese People’s Liberation Army Hospital, Beijing 100853, China Institute These authors have contributed equally to this work Correspondence to: Chen, email: chenlinbj@sina.com Wei, weibo@vip.163.com Wu, wuxs216@163.com Keywords: colon cancer; shikonin; ROS; mitochondria; apoptosis...
Abstract Background Stearoyl-CoA desaturase-1 (SCD1) is reported to play essential roles in cancer stemness among several cancers. Our previous research revealed significant overexpression of SCD1 primary gastric stem cells (GCSCs), with its functional role still unknown. Methods We stably established three GCSCs by sphere-forming assays and flow cytometry. Protein quantification bioinformatics analysis were performed reveal the differential protein pattern. Lentivirus-based...
The neuromorphic vision system (NVS) equipped with optoelectronic synapses integrates perception, storage, and processing is expected to address the issues of traditional machine vision. However, owing their lack stereo vision, existing NVSs focus on 2D image processing, which makes it difficult solve problems such as spatial cognition errors low-precision interpretation. Consequently, inspired by human visual system, an NVS developed achieve 3D object recognition, depending prepared ReS2...