A5100750521- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Osteoarthritis Treatment and Mechanisms
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Spine and Intervertebral Disc Pathology
- Knee injuries and reconstruction techniques
- Pulmonary Hypertension Research and Treatments
- Histone Deacetylase Inhibitors Research
- Adipose Tissue and Metabolism
- Ultrasound and Hyperthermia Applications
- Sirtuins and Resveratrol in Medicine
- Ferroptosis and cancer prognosis
- Plant-based Medicinal Research
- ATP Synthase and ATPases Research
- Cancer Cells and Metastasis
- Traditional Chinese Medicine Studies
- Cardiac Imaging and Diagnostics
Shanghai Jiao Tong University
2014-2025
Nanjing University
2025
Macau University of Science and Technology
2023-2025
Shanghai Cancer Institute
2024
Wenzhou Medical University
2023-2024
Lu'an First People's Hospital
2019-2024
Anhui Medical University
2019-2024
Quzhou University
2024
Sichuan University
2021-2024
West China Hospital of Sichuan University
2021-2024
Abstract Human hexokinase 2 is an essential regulator of glycolysis that couples metabolic and proliferative activities in cancer cells. The binding to the outer membrane mitochondria critical for its oncogenic activity. However, regulation remains unclear. Here, we report SUMOylation regulates mitochondria. We find can be SUMOylated at K315 K492. SUMO-specific protease SENP1 mediates de-SUMOylation 2. SUMO-defective preferably binds enhances both glucose consumption lactate production...
The metabolic program is altered during macrophage activation and influences polarization. Glutaminolysis promotes accumulation of α-ketoglutarate (αKG), leading to Jumonji domain-containing protein D3 (Jmjd3)-dependent demethylation at H3K27me3 M2 polarization macrophages. However, it remains unclear how αKG regulated This study shows that SENP1-Sirt3 signaling controls glutaminolysis, IL-4-stimulated Activation the axis augments through via glutaminolysis. We also identify glutamate...
Abstract Metabolic programming and mitochondrial dynamics along with T cell differentiation affect fate memory development; however, how to control metabolic reprogramming in development is unclear. Here, we provide evidence that the SUMO protease SENP1 promotes via Sirt3 deSUMOylation. SENP1-Sirt3 signalling augments deacetylase activity of Sirt3, promoting both OXPHOS fusion. Mechanistically, activates mitochondria, leading reduction acetylation metalloprotease YME1L1. Consequently,...
Abstract Mitochondria are cellular powerhouses that generate energy through the electron transport chain (ETC). The mitochondrial genome (mtDNA) encodes essential ETC proteins in a compartmentalized manner, however, mechanism underlying metabolic regulation of mtDNA function remains unknown. Here, we report expression tricarboxylic acid cycle enzyme succinate-CoA ligase SUCLG1 strongly correlates with genes across various TCGA cancer transcriptomes. Mechanistically, restricts succinyl-CoA...
One major function of adipocytes is to store excess energy in the form triglycerides. Insufficient adipose lipid storage associated with many pathological conditions including hyperlipidemia, insulin resistance, and type 2 diabetes. In this study, we observed overexpression SUMO-specific protease (Senp2) tissues during obesity. Adipocyte Senp2 deficiency resulted less accompanied by an ectopic fat accumulation resistance under high-fat diet feeding. We further found that SET domain...
Zinc plays a role in mitophagy and protects cardiomyocytes from ischemia/reperfusion injury. This study is aimed at investigating whether SUMOylation of Drp1 involved the protection zinc ion on cardiac I/R Mouse hearts were subjected to 30 minutes regional ischemia followed by 2 hours reperfusion (ischemia/reoxygenation (I/R)). Infarct size apoptosis assessed. HL-1 cells 24 hypoxia 6 reoxygenation (hypoxia/reoxygenation (H/R)). was given 5 min before for min. SENP2 overexpression plasmid...
3d printing has been a recent research hotspot because of the performance accurately, easy to operate and can complete more complex objects, there are many advantages missing in subtractive manufacturing, at same time match requirements orthopaedic implant scaffolds, scaffolds as one main applications bone tissue regeneration (BTR) also commonly studied, current literature is mostly its raw materials do research. This paper introduces three gives some examples illustrate role or implants...
Abstract The human microbiome exhibits a profound connection with the cancer development, progression, and therapeutic response, particular emphasis on its components of mycobiome, which are still in early stages research. In this review, we comprehensively summarize cancer‐related symbiotic pathogenic fungal genera. intricate mechanisms through fungi impact as an integral member both gut tissue‐resident microbiomes further discussed. addition, shed light pivotal physiological roles various...
Abstract Objective Anti-melanoma differentiation–associated gene 5 (Anti-MDA5)–positive DM is a rare but life-threatening autoimmune disorder that associated with high risk of developing rapidly progressive interstitial lung disease. Current empirical therapies offer limited benefit in terms patient survival, as little known about the aetiology anti-MDA5 DM. To best understand its immune landscape, we applied single-cell RNA sequencing (scRNA-seq) to peripheral blood samples from patients...
The present study aimed to investigate the effects of 17β-estradiol (E2) and 2-methoxyestradiol (2ME) on oxidative stress-hypoxia inducible factor-1 (OS-HIF-1) pathway in hypoxic pulmonary hypertensive rats. Female Sprague‑Dawley rats were divided randomly into 4 groups, as follows: i) Control (Group A); ii) ovariectomy (OVX) + hypoxia B); iii) OVX E2 injection C); iv) 2ME D). maintained under conditions for 8 weeks, mean artery pressure (mPAP) arteriole morphology measured. reactive oxygen...
Abstract Increasing lines of evidence indicate the role long non-coding RNAs (LncRNAs) in gene regulation and tumor development. Hence, it is important to elucidate mechanisms LncRNAs underlying proliferation, metastasis, invasion lung adenocarcinoma (LUAD). We employed microarrays screen LUAD tissues with without lymph node metastasis revealed their effects on LUAD. Among them, Linc00426 was selected for further exploration its expression, biological significance, molecular mechanisms....
The present study is aimed at exploring the specific expression of miR-193a-3p and mechanism underlying miR-193a-3p-mediated mesenchymal transition (MT), invasion, migration in glioma.The gene profile datasets GSE39486 GSE25676 were downloaded from National Center for Biotechnology (NCBI). Data regarding survival curves derived Chinese Glioma Genome Atlas (CGGA). Online websites including miRWalk, DIANA, starbase employed to predict target genes miR-193a-3p. Gene Ontology (GO) Kyoto...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a profoundly aggressive and fatal cancer. One of the key factors defining its aggressiveness resilience against chemotherapy existence cancer stem cells (CSCs). The important task discovering upstream regulators stemness that are amenable for targeting in PDAC essential advancement more potent therapeutic approaches. In this study, we sought to elucidate function nuclear receptor subfamily 5, group A, member 2 (NR5A2) context...
Hepatocellular carcinoma (HCC) stands as the third leading cause of cancer-related fatalities globally. In this study, we observed a significant increase in expression level YEATS2 gene HCC patients, and it is negatively correlated with patients' survival rate. While have previously identified association between pancreatic cancer cells, regulatory mechanisms significance are still to be fully elucidated. Our study shows that knockdown (KD) leads DNA damage, which turn results an...
Abstract Purpose The purpose of this study was to analyse the difference between arthroscopic fixation and open reduction internal (ORIF) posterior cruciate ligament (PCL) tibial avulsion fractures. Methods This retrospective analysed patients with an acute PCL fracture who underwent surgical treatment at our hospital follow-up for least 24 months. Variables based on sex, age, Meyers–McKeever type, method, meniscus tear, external fixation, labour or sports, Lysholm knee score, IKDC KT-1000...
Pancreatic ductal adenocarcinoma (PDAC) poses significant clinical challenges, often presenting as unresectable with limited biopsy options. Here, we show that circulating tumor cells (CTCs) offer a promising alternative, serving "liquid biopsy" enables the generation of in vitro 3D models and highly aggressive vivo for functional molecular studies advanced PDAC. Within retrieved CTC pool (median 65 CTCs/5 mL), identify subset content 8.9%) CXCR4