A5100640842- RNA modifications and cancer
- Systemic Lupus Erythematosus Research
- Sepsis Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Diet, Metabolism, and Disease
- Renal Diseases and Glomerulopathies
- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Vasculitis and related conditions
- Adipose Tissue and Metabolism
- Amoebic Infections and Treatments
- EEG and Brain-Computer Interfaces
- Neurological Disease Mechanisms and Treatments
- Autoimmune and Inflammatory Disorders Research
- Frailty in Older Adults
- MicroRNA in disease regulation
- Kawasaki Disease and Coronary Complications
- Computational Drug Discovery Methods
- Neonatal and Maternal Infections
- interferon and immune responses
- Neonatal Respiratory Health Research
- Bariatric Surgery and Outcomes
- Immune cells in cancer
- Sirtuins and Resveratrol in Medicine
Shanghai Children's Medical Center
2014-2025
Shanghai Jiao Tong University
2016-2025
Chengdu Third People's Hospital
2025
Renji Hospital
2009-2025
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2025
Huazhong University of Science and Technology
2019-2025
Chengdu Medical College
2025
Hunan Normal University
2024
Hunan Provincial People's Hospital
2024
The metabolic program is altered during macrophage activation and influences polarization. Glutaminolysis promotes accumulation of α-ketoglutarate (αKG), leading to Jumonji domain-containing protein D3 (Jmjd3)-dependent demethylation at H3K27me3 M2 polarization macrophages. However, it remains unclear how αKG regulated This study shows that SENP1-Sirt3 signaling controls glutaminolysis, IL-4-stimulated Activation the axis augments through via glutaminolysis. We also identify glutamate...
Abstract Metabolic programming and mitochondrial dynamics along with T cell differentiation affect fate memory development; however, how to control metabolic reprogramming in development is unclear. Here, we provide evidence that the SUMO protease SENP1 promotes via Sirt3 deSUMOylation. SENP1-Sirt3 signalling augments deacetylase activity of Sirt3, promoting both OXPHOS fusion. Mechanistically, activates mitochondria, leading reduction acetylation metalloprotease YME1L1. Consequently,...
Abstract Cytokine storm (CS) is linked with macrophage dysfunction and acute lung injury (ALI), which can lead to patient mortality. Glycolysis preferentially exploited by the pro-inflammatory macrophages, in pyruvate kinase M2 (PKM2) a critical enzyme. The mechanism underlying link between CS ALI involves cell death, recently discovered programmed death known as ferroptosis being involved. However, relationship glycolysis context of CS-related remains unclear. CS-associated induced poly I:C...
Bis-(−)-nor-meptazinols (bis-(−)-nor-MEPs) 5 were designed and synthesized by connecting two (−)-nor-MEP monomers with alkylene linkers of different lengths via the secondary amino groups. Their acetylcholinesterase (AChE) inhibitory activities more greatly influenced length chain than butyrylcholinesterase (BChE) inhibition. The most potent nonamethylene-tethered dimer 5h exhibited low-nanomolar IC50 values for both ChEs, having a 10 000-fold 1500-fold increase in inhibition AChE BChE...
Patients with metastatic cancer refractory to standard systemic therapies have a poor prognosis and few therapeutic options. Radiotherapy can shape the tumor microenvironment (TME) by inducing immunogenic cell death promoting recognition natural killer cells T lymphocytes. Granulocyte macrophage-colony stimulating factor (GM-CSF) was known promote dendric maturation function, might also induce macrophage polarization anti-tumor capabilities. A phase II trial (ChiCTR1900026175) conducted...
Abstract Bariatric surgery is an effective method to rapidly induce weight loss in severely obese people, however its impact on brain functional connectivity after longer periods of follow-up yet be assessed. We investigated changes 16 women one month before, and year Roux-en-Y gastric bypass (RYGB). 12 lean controls were also enrolled. Resting-state fMRI was acquired for all participants following overnight fast a 260 kcal load. Connectivity between regions involved food-related saliency...
Osteopontin (OPN) is a multifunctional protein expressed in many cell types, tissues and body fluids with the highest concentrations found milk; significantly higher human than bovine milk. Intervention studies have indicated beneficial effects of supplementing infant formula OPN. In this multicenter study, we determined OPN content milk samples from 629 Chinese, Danish, Japanese Korean mothers.At each study site, were collected analyzed for concentration using ELISA infrared spectroscopy,...
Objective This study aimed to evaluate the potential role of whole-exome sequencing (WES) technique in screening pathogenic genes non-cirrhotic and non-malignant portal vein thrombosis (PVT) clinical efficacy AngioJet-assisted pharmacomechanical thrombectomy (PMT) with transjugular intrahepatic portosystemic stent shunt (TIPS) treat this disease. Methods 16 patients acute PVT were retrospectively analyzed. 14 received genetically diagnosed using WES technique, ten PMT or without TIPS 6 cases...
Background: Candida species is an important cause of nosocomial infection in neonatal intensive care units (NICUs). However, most reports China have been limited to single institutions. The aim this study investigate the epidemiology invasive candidiasis multiple NICUs across China. Methods: We retrospectively collected demographic data, clinical characteristics, microbiological results and outcome preterm infants with discharged from 11 academic tertiary during January 2009 December 2011....
To analyse the clinical features of Henoch-Schönlein purpura (HSP) with or without nephritis in Chinese children and to determine risk factors for renal involvement.Patient characteristics, parameters laboratory data were retrospectively analysed patients HSP nephritis. Logistic regression analysis was used identify involvement.A total 535 included study. occurred 267 (49.9%), ranging from isolated haematuria 5.2%, mild proteinuria 77.5%, moderate 6.4% severe 10.9% cases. In 90% cases,...
Xuebijing (XBJ) can alleviate the inflammatory response, improve organ function, and shorten intensive care unit (ICU) stay in patients with pyogenic liver abscess (PLA) complicated sepsis, but molecular mechanisms have not been elucidated. This study aimed to explore mechanism of XBJ treating PLA sepsis using a network pharmacology approach.
In this paper, a support vector machine (SVM) approach using statistical features, P wave absence, spectrum and length-adaptive entropy are presented to classify ECG rhythms as four types: normal rhythm, atrial fibrillation (AF), other too noisy classify.The proposed algorithm consisted of three steps: (1) signal pre-processing based on the wavelet method; (2) feature extraction, extracted features including one power feature, two 17 RR interval-related 11 features; (3) classification SVM...
Abstract Background The definition of sepsis is regularly updated; however, there no standard diagnostic test. To improve diagnosis and prognostic prediction, the aim this study was to determine predictive value circulating plasma mitochondrial DNA (mtDNA) levels in patients admitted emergency department (ED) with sepsis. Methods A total 107 hospitalized from June 2018 January 2019 were divided into ( n = 72) septic shock 35) groups based on sepsis-3 definition. Clinical laboratory data...