A5064399135- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Infant Nutrition and Health
- Neonatal and Maternal Infections
- Liver Disease Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Cardiovascular Conditions and Treatments
- Epigenetics and DNA Methylation
- Pneumonia and Respiratory Infections
- Neuroscience of respiration and sleep
- Gestational Trophoblastic Disease Studies
- Eosinophilic Disorders and Syndromes
- Histiocytic Disorders and Treatments
- Tracheal and airway disorders
- Diet, Metabolism, and Disease
- Blood Coagulation and Thrombosis Mechanisms
- Vascular Malformations and Hemangiomas
- Pediatric Hepatobiliary Diseases and Treatments
- Respiratory Support and Mechanisms
- COVID-19 Impact on Reproduction
- Bacterial Infections and Vaccines
- Retinopathy of Prematurity Studies
- Platelet Disorders and Treatments
- Hedgehog Signaling Pathway Studies
XinHua Hospital
2013-2024
Shanghai Jiao Tong University
2013-2024
Southwest Medical University
2024
Chengdu Women's and Children's Central Hospital
2024
University of Electronic Science and Technology of China
2024
Affiliated Hospital of Southwest Medical University
2024
Cincinnati Children's Hospital Medical Center
2014
Guangzhou Women and Children Medical Center
2013
Guangzhou Medical University
2013
Premature infants often require oxygen supplementation, which can elicit bronchopulmonary dysplasia (BPD) and lead to mitochondrial dysfunction. Mitochondria play important roles in lung development, both normal metabolism apoptosis. Enhancing our comprehension of the underlying mechanisms BPD development facilitate effective treatments. Plasma samples from non-BPD were collected at 36 weeks post-menstrual age used for metabolomic analysis. Based on hyperoxia-induced animal cell models,...
Objectives The field of view through transanal endoscopic provides new treatment approaches for solving complex clinical problems. TAMIS belongs to single-port surgery, and the operation is complex. Analyzing learning curve aims facilitate its better promotion. Methods A retrospective cohort study analyzed data 58 patients who underwent by same surgeon from January 2018 October 2024. was obtained using cumulative sum (CUSUM) analysis, optimal number surgeries determined based on peak value...
Current treatments for inflammation associated with bronchopulmonary dysplasia (BPD) fail to show clinical efficacy. Foxm1, a transcription factor of the Forkhead box family, is critical mediator lung development and carcinogenesis, but its role in BPD-associated pulmonary unknown. Immunohistochemistry RNA analysis were used assess Foxm1 tissue from hyperoxia-treated mice patients BPD. LysM-Cre/Foxm1(-/-) mice, which was deleted myeloid-derived inflammatory cells, including macrophages,...
Background: Candida species is an important cause of nosocomial infection in neonatal intensive care units (NICUs). However, most reports China have been limited to single institutions. The aim this study investigate the epidemiology invasive candidiasis multiple NICUs across China. Methods: We retrospectively collected demographic data, clinical characteristics, microbiological results and outcome preterm infants with discharged from 11 academic tertiary during January 2009 December 2011....
Background . Retinopathy of prematurity (ROP) is one the common complications prematurity. Intravitreal injection ranibizumab (IVR), an antivascular endothelial growth factor (VEGF) drug, showed significant benefit for ROP. However, there are concerns about systemic anti-VEGF therapy in preterm infants. Objectives To evaluate serum VEGF level circulation after IVR and associated with premature infants Methods This prospective investigation assessed concentrations ROP patients before therapy....
Objectives: To investigate the association between serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) level on first day of life and a composite outcome bronchopulmonary dysplasia (BPD) or death in cohort infants born before 32 weeks gestation. Methods: We retrospectively identified gestation who had NT-proBNP levels measured when they were admitted to Neonatal Intensive Care Unit shortly after birth. The BPD was assessed at 36 postmenstrual age. with evaluated. Receiver operator...
Glutathione synthetase deficiency (GSSD) is a rare inborn error of glutathione metabolism with autosomal recessive inheritance. The severe form the disease characterized by acute metabolic acidosis, usually present in neonatal period hemolytic anemia and progressive encephalopathy. A case male newborn infant who had acidosis high anion gap, anemia, hyperbilirubinemia reported. level 5-oxoproline was detected his urine diagnosis generalized GSSD made. DNA sequence analysis revealed to be...
Abstract Metformin has potential anti‐inflammatory properties and accelerates wound healing by enhancing vascular development. In this study, we aimed to investigate the effects of metformin on pulmonary development underlying mechanism. Newborn mice were subcutaneously injected with from day 2 after exposure hyperoxia. Pulmonary development, inflammation, Shh signaling pathway‐related protein expression evaluated western blotting immunofluorescence staining. M2 macrophage polarization was...
Background: Several non-invasive markers have been reported as being effective for the assessment of fibrosis in adults with chronic viral hepatitis. The infantile liver is more susceptible to cholestasis, and it important promptly evaluate guide clinical treatment. However, value these infants cholestasis remains unknown. Aim: To investigate correlation between serum laminin (LN), hyaluronic acid (HA), procollagen III N-terminal peptide (PIIINP) level, stage cholestasis. Methods: One...
Abstract Background: Intrauterine valvuloplasty is an innovative therapy, which promotes ventricular growth and function in some congenital heart diseases (CHDs). The technique remains challenging can only be performed a few centers. This study aimed to assess the feasibility mid-term outcomes of fetal cardiac intervention (FCI) fetuses with critical CHD experienced tertiary center. Methods: Five aortic (FAV) or pulmonary (FPV) procedures were our center between August 2018 May 2022....
Background: Pulmonary stenosis (PS) is one rare congenital heart disease (CHD) featuring obstruction of right ventricular outflow tract. Critical pulmonary (CPS) neonatal PS having cyanosis and evidence patent ductus arteriosus (PDA) dependency. There limited data on the clinical outcomes CPS with different modes transportation. This study aimed to investigate features through intrauterine transport (IT) postnatal (PT). Methods: Single-center retrospective research was performed. Neonates...
Abstract Background The occurrence of severe intraventricular hemorrhage (sIVH) was high in the very preterm infants (VPIs) China. management strategies significantly contributed to sIVH VPIs. However, status perinatal associated with for VPIs rarely described across multiple neonatal intensive care units (NICUs) We aim investigate characteristics NICUs Methods This a retrospective analysis data from prospective cohort Chinese Neonatal Network (CHNN) dataset, enrolling born at 24 +0 —31 +6...
Abstract This multicenter retrospective study was conducted to explore the effects of different courses and durations invasive mechanical ventilation (MV) on respiratory outcomes very low birth weight infants (VLBWI) in China. The population for this consisted with less than 1500 g needing at least 1 course MV admitted neonatal intensive care units affiliated Chinese Neonatal Network within 6 h life from January 1st, 2019 December 31st, 2020. Univariate multivariate logistic regression...
Objectives: To determine the efficacy of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in predicting critical pulmonary stenosis (CPS) neonates. Methods: All neonates with (PS) admitted to neonatal intensive care unit Xinhua Hospital from October 2014 December 2020 were retrospectively reviewed. Infants NT-proBNP measured within 48 h after birth enrolled and divided into CPS non-CPS groups. Serum cardiac Doppler indices compared between two Correlations determined using...
Objective: To explore the high risk factors of stillbirth. Methods: 176 cases stillbirth were collected in Obstetrics and Gynecology Hospital Fudan University from January 1(st), 2010 to December 31(st), 2016. All analyzed retrospectively, including general profile, different years pregnancy periods. Results: (1) The incidence was 0.178%(176/98 785). Stillbirth occured mostly at 28-28(+6) gestational weeks (10.8%,19/176), second peak 29-29(+6) weeks(10.2%,18/176), while third common period...