A5068437924- Retinopathy of Prematurity Studies
- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Neonatal Respiratory Health Research
- Retinal Development and Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Intraocular Surgery and Lenses
- Bioinformatics and Genomic Networks
- Topic Modeling
- Cardiovascular Health and Risk Factors
- Glaucoma and retinal disorders
- Natural Language Processing Techniques
- Wnt/β-catenin signaling in development and cancer
- Liver Disease Diagnosis and Treatment
- Air Quality and Health Impacts
- Neonatal Health and Biochemistry
- Metabolism, Diabetes, and Cancer
- Ocular Diseases and Behçet’s Syndrome
- Ocular Oncology and Treatments
- Air Quality Monitoring and Forecasting
- Preterm Birth and Chorioamnionitis
- Cancer-related gene regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Chronic Kidney Disease and Diabetes
- Connexins and lens biology
Shanghai Jiao Tong University
2016-2025
Ruijin Hospital
2011-2025
XinHua Hospital
2015-2024
East China Normal University
1994-2024
Second People Hospital of Hunan
2024
Central South University
2024
Second Xiangya Hospital of Central South University
2024
Tongji Hospital
2023
Huazhong University of Science and Technology
2023
Huadong Hospital
2020-2021
Objective— To evaluate the associations between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis. Methods Results— A total of 8632 participants aged ≥40 years from Jiading district, Shanghai, were included in present study. The presence NAFLD was evaluated by ultrasonography. Carotid intima-media thickness (CIMT) brachial-ankle pulse wave velocity (ba-PWV) measured each participant. prevalence 30.0% population, with 30.3% men 29.9% women, respectively. Subjects had remarkably...
Abstract Diabetic foot ulcers (DFUs) are chronic, difficult‐to‐heal wounds with a very high incidence of amputation. For patients DFUs, prevention amputation is crucial. However, the risk factors associated DFU and extent to which different increase still uncertain. This study intends provide clinical basis for early intervention in by retrospectively analysing A retrospective analysis 200 DFUs admitted between October 2019 2023 was conducted. Sixty‐eight underwent amputations. The overall...
To analyze the incidence and severity of retinopathy prematurity (ROP) in China, to explore workload implications applying different criteria.A prospective, neonatal units-based study undertaken two tertiary level hospitals Shanghai, from January 1, 2010 December 31, 2012. All infants with birth weight (BW) 2000 g or less and/or gestational age (GA) 34 weeks were screened for ROP. Retinopathy was classified using international classification, treated accordance recommendations Early...
Purpose: To investigate timing and risk factors of recurrent retinopathy prematurity (ROP) after intravitreal ranibizumab (IVR) monotherapy. Methods: Fifty eyes (the more severe eye) 50 infants treated with IVR monotherapy for type 1 ROP were studied retrospectively. The mean follow-up time was 31 weeks IVR. Recurrent (recurrence extraretinal fibrovascular proliferation [EFP]) determined by RetCam wide-angle fundus imaging binocular indirect ophthalmoscopy. Risk recurrence estimated...
Mutations in the human BEST1 gene lead to retinal degenerative diseases displaying progressive vision loss and even blindness. BESTROPHIN1, encoded by BEST1, is predominantly expressed pigment epithelium (RPE), but its physiological role has been a mystery for last two decades. Using patient-specific iPSC-based disease model interdisciplinary approaches, we comprehensively analyzed distinct patient mutations, discovered mechanistic correlations between clinical phenotypes, electrophysiology...
ABSTRACT Identifying factors affecting lifespan, including genes or proteins, enables effective interventions. We prioritized potential drug targets and provided insights into biological pathways for healthy longevity by integrating Mendelian randomization, cohort, experimental studies. identified causal effects of tissue‐specific genetic transcripts serum protein levels on three outcomes: the parental top 1% 10% extreme longevity, utilizing randomization multi‐traits colocalization,...
Background Ischemic stroke, accounting for approximately 80% of all stroke cases, is a major public health challenge and leading cause death disability worldwide. Current treatments primarily involve thrombolytic therapy, limited to 4.5-hour window due the risk complications, underscoring need new therapeutic targets. Systemic inflammation plays critical role in progression, with immune cells infiltrating brain exacerbating damage. B cells, particular, have been implicated pathogenesis,...
We characterized the ocular pharmacokinetics of bevacizumab in vitrectomized eyes with silicone oil tamponade.A total 18 pigmented rabbits underwent vitrectomy and tamponade before an intra-silicone injection 1.25 mg bevacizumab. At post-injection days 1, 7, 14, 28, 42, 56, 3 were sacrificed enucleated, concentrations measured various tissues plasma.The peak concentration was reached at day 14 aqueous humor (4030.70 ng/mL), retina (42,171.7 ng/g), choroid (56,243.33 ng/g). In iris/ciliary...
No generally accepted thresholds for quantitative ultrasound (QUS) parameters to screen individuals at high risk of osteoporotic fractures have been defined.We sought define appropriate cutoff points calcaneus according participants' prevalent fractures.This was a cross-sectional, population-based study conducted in Shanghai, China.A total 9352 Chinese women and men aged 40 older were studied.We measured QUS (Achilles Express, GE Lunar) values their relationships with fractures.A prevalence...
Background Previous studies indicated that apolipoprotein measurements predicted cardiovascular disease (CVD) risk; however, associations between apolipoproteins and carotid intima-media thickness (CIMT) were less explored. Methodology Principal Findings The cross-sectional study included 6069 participants aged 40 years or older with NGT from Shanghai, China. Serum fasting traditional lipids (total cholesterol [TC], low-density lipoprotein [LDL-C], high-density [HDL-C] triglycerides [TG]),...
Retinitis pigmentosa (RP) is an incurable neurodegenerative condition featuring photoreceptor death that leads to blindness. Currently, there no approved therapeutic for degenerative conditions like RP and atrophic age-related macular degeneration (AMD). Although are promising results in human gene therapy, a genetically diverse disorder, such gene-specific therapies would be practical small fraction of patients with RP. Here, we explore non-gene-specific strategy entails reprogramming...
Objectives Nationwide studies focusing on the impact of early-onset type 2 diabetes and obesity development cardiovascular diseases (CVD) are limited in China. We aimed to investigate association between age at diagnosis risk CVD, further examine modifying effect this among Chinese adults. Methods This study included 23,961 participants with previously diagnosed from a large nationwide population-based cohort across mainland With an interviewer-assisted questionnaire, we collected detailed...
The burgeoning interest in two-dimensional semiconductors stems from their potential as ultrathin platforms for next-generation transistors. Nonetheless, there persist formidable challenges fully obtaining high-performance complementary logic components and the underlying mechanisms polarity modulation of transistors are not yet understood. Here, we exploit both ferroelectric domain-based nonvolatile Fermi level transitional metal dichalcogenides (MoS
To evaluate the effect of early vitreoretinal surgery on vascularly active stage 4 ROP through preoperative use intravitreal bevacizumab.This was a retrospective study. Eighteen patients with who underwent primary vitrectomy from April 2007 to March 2010 were enrolled. Twelve eyes eight received one-time injection 0.625 mg bevacizumab 7 days prior (bevacizumab group), and 11 10 surgical procedure without (control group). Demographical information all recorded. The followed up for 12-36...
We sought to better characterize the intravitreal profile of different triamcinolone formulations.The study was performed in vitro and vivo. Kenalog-40, Triesence, Transton were characterized for ocular pharmacokinetics, particle size, crystallinity, dissolving kinetics vitreous following an injection into 12 rabbit eyes. The relationship free drug levels aqueous investigated through a dual-probe microdialysis liquid chromatography tandem mass spectrometry.Triesence had most uniform size...
Abstract Usher syndrome is an inherited and irreversible disease that manifests as retinitis pigmentosa (RP) bilateral neurosensory hearing loss. Mutations in Usherin 2A (USH2A) are not only a frequent cause of syndrome, but also nonsyndromic RP. Although gene- cell-based therapies on the horizon for RP studies characterizing natural lacking. In this retrospective analysis, retinal function USH2A patients was quantified with electroretinography. Both groups had markedly reduced rod cone...
Abstract Purpose Early detection of ocular abnormalities in newborns is essential for timely diagnosis and treatment. This study aimed to assess the 1‐year result a multicentre prospective neonatal eye examination programme with wide‐field digital imaging system China. Methods A collaborative group screening was established nine hospitals, including eight Maternal Children's Hospitals, one general hospital across China from July 2016 June 2017. Ocular examinations were performed on within 28...
Background Diabetes mellitus, especially type 2 diabetes mellitus (T2DM), is regarded as highly heterogeneous. Novel phenotypes by cluster analysis have been proposed in Europeans but may show different features Asians. The applicability of middle-aged and elderly Chinese community T2DM patients needs further investigation. Methods Participants were recruited from Jiading Shanghai, China. We adopted k-means 1130 (aged ≥ 40 years) with newly-diagnosed at baseline. Cluster was performed based...