A5014014461- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Herpesvirus Infections and Treatments
- Parvovirus B19 Infection Studies
- Semiconductor Lasers and Optical Devices
- Photonic and Optical Devices
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- Histiocytic Disorders and Treatments
- Ruminant Nutrition and Digestive Physiology
- Animal Nutrition and Physiology
- Algal biology and biofuel production
- Moringa oleifera research and applications
- Semiconductor Quantum Structures and Devices
- HIV Research and Treatment
- Hepatitis C virus research
- Lymphoma Diagnosis and Treatment
- Mosquito-borne diseases and control
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Phytase and its Applications
- Cancer-related molecular mechanisms research
- Advanced Electron Microscopy Techniques and Applications
Henan Agricultural University
2019-2025
Henan University
2019-2025
Guizhou University
2023-2025
Haikou Experimental Station
2024
Ministry of Agriculture and Rural Affairs
2024
Capital Medical University
2024
Beijing Children’s Hospital
2024
Hunan Cancer Hospital
2022-2024
Central South University
2022-2024
Guangxi University
2023-2024
Nasopharyngeal carcinoma, Kaposi's sarcoma, and B-cell lymphomas are human malignancies associated with gammaherpesvirus infections. Members of this virus family characterized by their ability to establish latent infections in lymphocytes. The viral genome expresses very few gene products. infected cells therefore poorly recognized the host immune system, allowing persist for long periods time. We sought identify cell-specific factors that allow these viruses redirect life cycle from...
Abstract Double-stranded RNA (dsRNA) is a virus-encoded signature capable of triggering intracellular Rig-like receptors (RLR) to activate antiviral signaling, but whether intercellular dsRNA structural reshaping mediated by the N 6 -methyladenosine (m A) modification modulates this process remains largely unknown. Here, we show that, in response infection virus Vesicular Stomatitis Virus (VSV), m A methyltransferase METTL3 translocates into cytoplasm increase on virus-derived transcripts...
β-coronaviruses reshape host cell endomembranes to form double-membrane vesicles (DMVs) for genome replication and transcription. Ectopically expressed viral nonstructural proteins nsp3 nsp4 interact zipper bend the ER DMV biogenesis. Genome-wide screens revealed autophagy VMP1 TMEM41B as important factors SARS-CoV-2 infection. Here, we demonstrated that biogenesis, induced by virus infection or expression of nsp3/4, is impaired in KO cells. In cells, nsp3/4 complex forms normally, but...
Abstract Zygotic genome activation (ZGA) marks the beginning of embryonic program for a totipotent embryo, which gives rise to inner cell mass (ICM) where pluripotent epiblast arises, and extraembryonic trophectoderm. However, how ZGA is connected first lineage segregation in mammalian embryos remains elusive. Here, we investigated role nuclear receptor (NR) transcription factors (TFs), whose motifs are highly enriched accessible from 2-cell (2C) 8-cell (8C) stages mouse embryos. We found...
Abstract Diabetic foot ulcers (DFUs) are chronic, difficult‐to‐heal wounds with a very high incidence of amputation. For patients DFUs, prevention amputation is crucial. However, the risk factors associated DFU and extent to which different increase still uncertain. This study intends provide clinical basis for early intervention in by retrospectively analysing A retrospective analysis 200 DFUs admitted between October 2019 2023 was conducted. Sixty‐eight underwent amputations. The overall...
Rta, mainly encoded by open reading frame 50 (ORF50), is the product of an immediate-early gene human herpesvirus-8 (HHV-8)/Kaposi’s sarcoma-associated herpesvirus. Rta a transcriptional activator that both necessary and sufficient to disrupt viral latency activate expression downstream lytic genes. We report ectopically expressed protein could also rta promoter on reporter plasmid up 144-fold, in latently infected B cells uninfected epithelial cells, this activation was dose-dependent....
ABSTRACT Human herpesvirus 8 (HHV-8; Kaposi's sarcoma-associated is linked to sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD), all of which are viewed as cytokine-driven malignancies. In particular, interleukin-6 (IL-6) has been found promote the growth proliferation cells from KS PEL. HHV-8 encodes a homologue IL-6 (viral [vIL-6]), functions similarly cellular IL-6. Therefore, vIL-6 proposed play an important role in tumor progression. Several...
The herpesvirus life cycle has two distinct phases: latency and lytic replication. balance between these phases is critical for viral pathogenesis. It believed that cellular signals regulate the switch from to To systematically evaluate regulating this reactivation process in Kaposi sarcoma-associated herpesvirus, effects of 26,000 full-length cDNA expression constructs on were individually assessed primary effusion lymphoma-derived cells harbor latent virus. A group diverse signaling...
Cholesterol 25-hydroxylase (CH25H) as an interferon-stimulated gene (ISG) has recently been shown to exert broad antiviral activity through the production of 25-hydroxycholesterol (25HC), which is believed inhibit virus-cell membrane fusion during viral entry. However, little known about function CH25H on HCV infection and replication whether exclusively mediated by 25HC. In present study, we have found that although 25HC produced can replication, mutants lacking hydroxylase still carry...
A conserved herpesvirus tegument protein recruits host phosphatase PPM1G to inactivate STING and MAVS for immune evasion.
Abstract The emergence of heavily mutated SARS-CoV-2 variants concern (VOCs) place the international community on high alert. In addition to numerous mutations that map in spike protein VOCs, expression viral accessory proteins ORF6 and ORF9b also elevate; both are potent interferon antagonists. Here, we present crystal structures Rae1-Nup98 complex with C-terminal tails (CTT) SARS-CoV 2.85 Å 2.39 resolution, respectively. An invariant methionine (M) 58 residue CTT extends its side chain...
Improving mammary gland epithelial cells proliferation through nutrition is an important approach for enhancing sow milk production and piglet growth. An intermediate metabolite of valine, 3-hydroxyisobutyrate (3-HIB), regulates cellular lipid metabolism. In the present study, we investigated effects 3-HIB on porcine The addition appropriate concentration significantly increased cell expression proteins associated with proliferation. Compared to control group, 0.4-0.8 mM levels mTOR...
Replication and transcription activator (RTA) (also referred to as ORF50), an immediate-early gene product of Kaposi's sarcoma-associated herpesvirus (KSHV)/(human 8), plays a critical role in balancing the viral life cycle between latency lytic replication. RTA has been shown act strong for several downstream genes KSHV. Direct binding DNA is thought be one important mechanisms transactivation target genes, while indirect are also implicated certain selected genes. This study demonstrated...
ABSTRACT Tegument is a unique structure of herpesvirus, which surrounds the capsid and interacts with envelope. Morphogenesis gammaherpesvirus poorly understood due to lack efficient lytic replication for Epstein-Barr virus Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8, are etiologically associated several types human malignancies. Murine 68 (MHV-68) genetically related gammaherpesviruses presents an excellent model studying de novo gammaherpesviruses. MHV-68 open reading frame...
MicroRNAs (miRNAs) are a new class of endogenous regulators broad range physiological processes, which act by regulating gene expression post-transcriptionally. The brassica vegetable, broccoli (Brassica oleracea var. italica), is very popular with wide consumers, but environmental stresses such as salinity problem worldwide in restricting its growth and yield. Little known about the role miRNAs response to salt stress. In this study, subjected stress grown under control conditions were...
A hepatitis C virus protein blocks NF-κB activation to suppress the antiviral immune response.
Indoor human speed estimation is critical to in-home health monitoring of elderly people since it can provide the moving status human. Contactless indoor with radio signals challenging due complicated relationship between and signals. In this article, we propose an framework, SpeedNet, estimate from Specifically, SpeedNet first extracts dominant path signal reflected through beamforming technique. Then, obtains doppler frequency shift (DFS) corresponding by analyzing short-time Fourier...
Virus assembly, which takes place during the late stage of viral replication, is essential for virus propagation. However, underlying mechanisms remain poorly understood, especially viruses with complicated structures. Here, we use correlative light and electron microscopy to examine formation cytoplasmic virion assembly compartments (cVACs) infection by a γ-herpesvirus. These cVACs are membraneless organelles liquid-like properties. Formation mediated ORF52, an abundant tegument protein....