A5085681006- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Advanced Memory and Neural Computing
- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- Dermatology and Skin Diseases
- NF-κB Signaling Pathways
- Ferroelectric and Negative Capacitance Devices
- Ferroelectric and Piezoelectric Materials
- 2D Materials and Applications
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Semiconductor materials and devices
- Perovskite Materials and Applications
- Acoustic Wave Resonator Technologies
- Multiferroics and related materials
- Organ and Tissue Transplantation Research
- Bacterial Identification and Susceptibility Testing
- Monoclonal and Polyclonal Antibodies Research
- Topological Materials and Phenomena
- IL-33, ST2, and ILC Pathways
- Antimicrobial Peptides and Activities
East China Normal University
2022-2025
Qilu Hospital of Shandong University
2022-2024
Zhejiang Lab
2024
University of Chicago
2011-2023
Center for Rheumatology
2008-2023
Institute of Cell Biology and Neurobiology
2004
Loyola University Chicago
2004
Bipar
2002
Abstract Among today’s nonvolatile memories, ferroelectric-based capacitors, tunnel junctions and field-effect transistors (FET) are already industrially integrated and/or intensively investigated to improve their performances. Concurrently, because of the tremendous development artificial intelligence big-data issues, there is an urgent need realize high-density crossbar arrays, a prerequisite for future memories emerging computing algorithms. Here, two-terminal ferroelectric fin diode...
Transplantation is the only cure for end-stage organ failure, but without immunosuppression, T cells rapidly reject allografts. While genetic disparities between donor and recipient are major determinants of kinetics transplant rejection, little known about contribution environmental factors. Because colonized organs have worse outcome than sterile organs, we tested influence host microbiota on skin rejection. Compared with untreated conventional mice, pretreatment donors recipients...
Analog storage through synaptic weights using conductance in resistive neuromorphic systems and devices inevitably generates harmful heat dissipation. This thermal issue not only limits the energy efficiency but also hampers very-large-scale highly complicated hardware integration as human brain. Here we demonstrate that can be simulated by reconfigurable non-volatile capacitances of a ferroelectric-based memcapacitor with ultralow-power consumption. The as-designed...
Abstract Acute allograft rejection has often been correlated with Th1 differentiation, whereas transplantation tolerance is frequently associated induction of regulation. The discovery the Th17 phenotype prompted its scrutiny in transplant rejection. Although IL-17 recently observed settings acute and drives T-bet-deficient mice that have impaired type 1 T cell responses, there little evidence requirement during wild-type animals. We others previously shown TLR9 signaling by exogenous CpG at...
Solid organ transplant recipients show heterogeneity in the occurrence and timing of acute rejection episodes. Understanding factors responsible for such variability patient outcomes may lead to improved diagnostic therapeutic approaches. Rejection kinetics transplanted organs mainly depends on extent genetic disparities between donor recipient, but a role environmental is emerging. We have recently shown that major alterations microbiota following broad-spectrum antibiotics, or use...
Innate effector cells that produce Th2-type cytokines are critical in Th2 cell-mediated immune responses. However, it is not known how these acquire the ability to cytokines. IL-4 a potent inducer directs differentiation of naive CD4(+) T into cells. To determine whether can induce and expansion cytokine-producing innate cells, we used mice whose il-4 gene was replaced by knock-in green fluorescence protein (gfp) gene. We found that, directly ex vivo, increased number GFP(+) airway lung...
Abstract Exposure to certain viruses and parasites has been shown prevent the induction of transplantation tolerance in mice via generation cross-reactive memory T cell responses or bystander activation. Bacterial infections are common perioperative period solid organ allograft recipients clinic, correlations between bacterial acute rejection have reported. However, whether at time any effect on remains be established. We used Gram-positive intracellular bacterium Listeria monocytogenes (LM)...
T cells have the capacity to eliminate tumors but signaling pathways by which they do so are incompletely understood. cell priming requires activation of transcription factors AP-1, NFAT and NF-κB downstream TCR, whether cell-NF-κB in vivo is required for tumor control has not been addressed. In humans mice with progressively growing tumors, activity cell-intrinsic often reduced. However, it clear if this causal an inability reject transformed cells, or a consequence growth. important...
Differential calculus is the cornerstone of many disciplines, spanning breadth modern mathematics, physics, computer science, and engineering. Its applications are fundamental to theoretical progress practical solutions. However, current state digital differential technology often requires complex implementations, which struggle meet extensive demands ubiquitous edge computing in intelligence age. To face these challenges, we propose an in-memory computation that capitalizes on dynamic...
Hirschsprung's disease (HSCR) is a congenital disorder characterized by the absence of enteric ganglion cells in distal colon, resulting functional intestinal obstruction. While genetic mutations and microenvironmental imbalances have been implicated HSCR, underlying molecular mechanisms are not fully understood. This study uses integrated quantitative proteomics phosphoproteomics analyses to characterize differential protein profiles phosphorylation modifications associated with HSCR. These...
Significance T lymphocytes are white blood cells that recognize and fight pathogens. Maintenance of sufficient numbers is essential to prevent susceptibility infections. Survival quiescent maintained, in part, by the interaction between soluble factor (IL-7 produced various stromal cells) IL-7 receptor (IL-7R) expressed on surface cells. Here, we show naïve have basal nuclear levels transcription NF-κB key maintain IL-7R expression for their survival. Our results imply antiinflammatory...
Obesity promotes a state of low-grade inflammation that exacerbates chronic inflammatory diseases, such as asthma and bowel disease. In transplantation, the survival organs transplanted into obese patients is reduced compared with allografts in lean recipients. However, whether this due to increased alloimmunity remains be addressed conclusively.We used mouse model high-fat diet (HFD)-induced obesity assessed immune responses allogeneic stimulation vitro, splenocyte immunization vivo, heart...
Abstract Despite that in-sensor processing has been proposed to remove the latency and energy consumption during inevitable data transfer between spatial-separated sensors, memories processors in traditional computer vision, its hardware implementation for artificial neural networks (ANNs) with all-in-one device arrays remains a challenge, especially organic-based ANNs. With advantages of biocompatibility, low cost, easy fabrication flexibility, here we implement self-powered ANN using...
The burgeoning interest in two-dimensional semiconductors stems from their potential as ultrathin platforms for next-generation transistors. Nonetheless, there persist formidable challenges fully obtaining high-performance complementary logic components and the underlying mechanisms polarity modulation of transistors are not yet understood. Here, we exploit both ferroelectric domain-based nonvolatile Fermi level transitional metal dichalcogenides (MoS
Solid organ transplantation is the preferred treatment for end-stage failure. Although transplant recipients take life-long immunosuppressive drugs, a substantial percentage of them still reject their allografts. Strikingly, barrier organs colonized with microbiota have significantly shorter half-lives than non-barrier transplanted organs, even in immunosuppressed hosts. We previously demonstrated that skin allografts monocolonized common human commensal Staphylococcus epidermidis (S.epi)...
Solid organ transplantation can treat end-stage failure, but the half-life of transplanted organs colonized with commensals is much shorter than that sterile organs. Whether colonization plays a role in this not known. We have previously shown an intact whole-body microbiota accelerate kinetics solid allograft rejection untreated mice when compared to germ-free (GF) or antibiotic-pre-treated mice, by enhancing capacity antigen presenting cells (APCs) activate graft-reactive T cells. However,...
Abstract Both type-2 CD4+ Th cells (CD4+Th2) and innate effector play critical roles in generating immunity that can either be protective against parasitic infection or cause tissue damage allergy asthma. How acquire the capacity to produce Th2 cytokines is not entirely known. We previously showed IL-4 induced differentiation of cytokine-producing eosinophils. To determine whether other also induce cells, we cultured bone marrow progenitor presence various cytokines. IL-5, but IL-13 IL-25,...
The induction of donor-specific tolerance remains a major goal in the field transplantation immunology. Therapies that target costimulatory molecules can induce to heart and pancreatic islet allografts mouse models, but fail do so after skin or intestinal allografts. We have proposed organs colonized by commensal bacteria such as skin, lung, intestine may be resistant therapies result bacterial translocation at time transplantation, which promote antigen-presenting cell maturation production...
There is considerable interest in investigating the role of microbiota various diseases, including transplant rejection. Germ-free (GF) and gnotobiotic mice are powerful models for this line investigation, but performing surgery within confines a sterile housing isolator exceptionally challenging. Development rigorous protocols to be able remove axenic from their surgical intervention Class II biological safety cabinet (BSC) without compromising sterility would give many investigators access...
Ferroelectric resistive switching (RS) devices with functional oxide electrodes allow controlled emergent phenomena at an interface. Here, we demonstrate RS polarity reversal due to ferroelectrically induced phase transition a doped charge transfer insulator For BiFeO3/Ca0.96Ce0.04MnO3 bilayers grown on NdAlO3 substrate, by applying voltages Ca0.96Ce0.04MnO3 bottom electrode, the resistance changes from high state (HRS) low (LRS) during positive voltage cycle (0 → 3 0 V), and LRS HRS...
Significance Activated naïve T cells acquire a memory state that improves their ability to respond second antigen encounter. Whether activated in tolerant settings can develop is less clear. Using mouse model of cardiac transplantation, we show alloreactive failed phenotypic and functional characteristics cells, but instead developed cell-intrinsic hyporesponsiveness. Acquiring the dysfunctional depended on alloantigen persistence duration exposure. Following infection-dependent abrogation...
Abstract We analyzed the responses of several T cell fractions reactive with superantigenic toxins (SAGTs), staphylococcal enterotoxin A (SEA), or Yersinia pseudotuberculosis-derived mitogen (YPM) in mice implanted mini-osmotic pumps filled SEA YPM. In pump, SEA-reactive Vβ3+CD4+ cells exhibited a high-level protracted expansion for 30 days, and Vβ11+CD4+ low-level expansion. CD8+ counterparts only transient similar difference was also observed YPM-reactive YPM pump. from pump divisions upon...
The influence of electrodes on antiferroelectricity and fatigue endurance 15 nm thick Hf0.2Zr0.8O2 thin films has been studied by a metal–antiferroelectric–metal capacitor structure using TiN W as electrodes. W|Hf0.2Zr0.8O2|W shows significantly enhanced better compared to the electrode. Assisted grazing incidence x-ray diffraction scanning transmission electron microscopy, different electrical properties are discussed based contents phases diffusion oxygen from film into