A5011034937- Mast cells and histamine
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Urticaria and Related Conditions
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Adenosine and Purinergic Signaling
- Skin and Cellular Biology Research
- Click Chemistry and Applications
- Dermatology and Skin Diseases
- Biotin and Related Studies
- Migraine and Headache Studies
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Supramolecular Self-Assembly in Materials
- Antimicrobial Peptides and Activities
- Psoriasis: Treatment and Pathogenesis
- Silk-based biomaterials and applications
- Monoclonal and Polyclonal Antibodies Research
- Hair Growth and Disorders
- Food Allergy and Anaphylaxis Research
- vaccines and immunoinformatics approaches
- CAR-T cell therapy research
University of Chicago
2012-2019
Macalester College
2010-2014
IL-17–producing CD4 T cells play a key role in immune responses against extracellular bacteria and autoimmunity. Nuclear factor κB (NF-κB) is required for T-cell activation selected effector functions, but its Th17 differentiation controversial. Using genetic mouse models that impede T-cell–NF-κB signaling either downstream of the receptor (TCR) or IκB kinase β (IKKβ), we demonstrate NF-κB controls not only survival proliferation activated cells, but, if cell cell-cycle progression are...
Adaptive immune responses, characterized by T cells and B engaging responding to specific antigens, can be raised biomaterials containing proteins, peptides, other biomolecules. How does one avoid, control, or exploit such responses? This review will discuss major properties processes that influence biomaterials-directed adaptive immunity, including the physical dimensions of a material, its epitope content, multivalency. Selected strategies involving novel designs discussed illustrate these...
Biomaterials used in the context of tissue engineering or wound repair are commonly designed to be "nonimmunogenic." However, previously it has been observed that self-assembled peptide nanofiber materials noninflammatory despite their immunogenicity, suggesting they may appropriate for use wound-healing contexts. To test this hypothesis, mice were immunized with epitope-containing self-assemblies until maintained high antibody titers against material, then gels same assemblies applied...
Significance Activated naïve T cells acquire a memory state that improves their ability to respond second antigen encounter. Whether activated in tolerant settings can develop is less clear. Using mouse model of cardiac transplantation, we show alloreactive failed phenotypic and functional characteristics cells, but instead developed cell-intrinsic hyporesponsiveness. Acquiring the dysfunctional depended on alloantigen persistence duration exposure. Following infection-dependent abrogation...
Abstract Pain is a cardinal component of inflammation and significant public health issue. Cytokines such as TNF-alpha, IL-1beta, IL-15 CXCL1/IL-8, well neutrophil influx have been implicated in the potentiation peripheral inflammatory pain models thermal mechanical hindpaw hypernociception rodents. These lines evidence point to sentinel mast cells tissues possible regulators these responses. Degranulation has shown be important for phosphorylation Erk nociceptive neurons rat model...