A5042585360- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Vaccine Coverage and Hesitancy
- Respiratory viral infections research
- Clostridium difficile and Clostridium perfringens research
- Mast cells and histamine
- Nosocomial Infections in ICU
- Congenital Diaphragmatic Hernia Studies
- Microscopic Colitis
- Pneumonia and Respiratory Infections
- Pain Mechanisms and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- COVID-19 epidemiological studies
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- Disaster Response and Management
- Skin and Cellular Biology Research
- COVID-19 diagnosis using AI
- Wound Healing and Treatments
- Hair Growth and Disorders
- Neonatal Respiratory Health Research
- Antimicrobial Peptides and Activities
- Data-Driven Disease Surveillance
- Asthma and respiratory diseases
- Healthcare cost, quality, practices
Universidad Panamericana
2022-2024
World Health Organization Regional Office for the Americas
2024
University of Edinburgh
2015-2022
Centre for Global Health Research
2016
Macalester College
2012-2013
Abstract Background The International Health Regulations (2005) (IHR), requires that States Parties develop their capacities to detect, assess, and respond public health threats report the World Assembly through Annual Report (SPAR). National Pandemic Preparedness Response Plans (PPRP) contribute countries however there are some discrepancies between both tools. To identify gaps define priority actions strengthen pandemic plans, we assessed concordance national preparedness response plans...
The interplay among pain, allergy and dysregulated inflammation promises to yield significant conceptual advances in immunology chronic pain. Hapten-mediated contact hypersensitivity reactions are used model skin allergies rodents but have not been utilized study associated changes pain perception the affected skin. Here we characterized mechanical hyperalgesia oxazolone-sensitized female mice challenged with single repeated labiar exposure oxazolone. Female were sensitized topical oxazolone...
<ns4:p><ns4:bold>Background: </ns4:bold>Neuro-inflammatory circuits in the tissue regulate complex pathophysiology of pain. Protective nociceptive pain serves as an early warning system against noxious environmental stimuli. Tissue-resident mast cells orchestrate increased thermal sensitivity following injection basic secretagogue compound 48/80 hind paw tissues ND4 mice. Here we investigated effects pre-treatment with TNF-α neutralizing antibody on 48/80-provoked hyperalgesia....
<ns4:p><ns4:bold>Background:</ns4:bold> Neuro-inflammatory circuits in the tissue regulate complex pathophysiology of pain. Protective nociceptive pain serves as an early warning system against noxious environmental stimuli. Tissue-resident mast cells orchestrate increased thermal sensitivity following injection basic secretagogue compound 48/80 hind paw tissues ND4 mice. Here we investigated effects pre-treatment with TNF-α neutralizing antibody on 48/80-provoked...
In April 2022, after a year of COVID-19 vaccination, there were large differences in coverage between urban and rural areas Guatemala. To address barriers communities, the "Health on Wheels" (HoW) strategy was implemented. The deployed mobile brigades with dedicated team health workers culturally sensitive promotion plan selected communities 15 districts Alta Verapaz, area low vaccination uptake high-level vaccine hesitancy. This study evaluates impact HoW strategy. We measured relative...
The world continues to undergo a profound demographic shift toward increasing longevity –but quality of life is not improving correspondingly. At the same time, countries are taking stock negative impacts COVID-19 pandemic on national immunization programs. exacerbated declines in vaccination coverage for multiple vaccine-preventable diseases (VPD). To ensure that all persons receive vaccines which they eligible, it time consider how applying course approach (LCA) programs can help...
To estimate the early impact of coronavirus disease 2019 (COVID-19) vaccination on cases in older populations four countries (Chile, Colombia, Guatemala, and United States America), deaths Chile Guatemala.Data were obtained from national databases confirmed COVID-19 vaccinations between 1 July 2020 31 August 2021. In each country, pre- post-vaccination incidence ratios calculated for prioritized groups (50-59, 60-69, ≥70 years) compared with those reference group (<50 years). Vaccination...
Abstract Vulvodynia can affect ~20% of women child-bearing age. Activities such as contact with tight clothing or sexual intercourse provoke burning pain sensations whose etiology and underlying mechanisms are poorly understood. Epidemiological evidence suggests a link between history environmental allergies the risk developing vulvodynia. Clinicians find increased mast cell numbers, hyperinnervation up-regulation inflammatory cytokines in biopsies from vulvodynia patients vs. controls. An...
Abstract SPE-7 anti-DNP-IgE initiates inflammatory cytokine production without antigen stimulation in vitro. In contrast, ϵ2624 anti-DNP IgE does not induce cytokines independent of antigen-stimulation. However, their effects vivo have been described. We tested two well-characterized anti-mouse antibody clones our model murine thermal hyperalgesia. found pronounced hindpaw hyperalgesic responses lasting to at least 6 hours following challenge after sensitization with SPE-7. These were...
Abstract Mast cells are involved in a range of physiologies and pathologies including allergic disease, defense against pathogens, neutralization venoms. Recently, these have been shown to play significant roles inflammatory pain. Acute inflammation is beneficial mechanism designed prevent further tissue damage; however, it can also lead decreased quality life and, as such, pervasive health concern. The involvement mast this process has not fully characterized. We show, cell-dependent model...