A5070568170- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Genetic Associations and Epidemiology
- Global Maternal and Child Health
- Child Nutrition and Water Access
- Nutrition, Genetics, and Disease
- Emergency and Acute Care Studies
- Influenza Virus Research Studies
- Glycosylation and Glycoproteins Research
- Child and Adolescent Health
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vaccine Coverage and Hesitancy
- Viral gastroenteritis research and epidemiology
- Diet and metabolism studies
- Tracheal and airway disorders
- Genetic factors in colorectal cancer
- Bacterial Infections and Vaccines
- Galectins and Cancer Biology
- Respiratory Support and Mechanisms
- Birth, Development, and Health
- Genetic and phenotypic traits in livestock
- Diabetes and associated disorders
- Genetic Mapping and Diversity in Plants and Animals
University of Edinburgh
2016-2025
Centre for Global Health Research
2016-2024
Karolinska Institutet
2023
Edinburgh College
2022
World Health Organization
1991-2022
Princess Alexandra Hospital NHS Trust
2021
Edinburgh Cancer Research
2020
Western General Hospital
1995-2020
Medical Research Council
1989-2020
Institute of Population and Public Health
2019-2020
Pneumococcal conjugate vaccine (PCV) and Haemophilus influenzae type b (Hib) are now used in most countries. To monitor global regional progress towards improving child health to inform national policies for disease prevention treatment, we prepared global, regional, burden estimates these pathogens children from 2000 2015.Using WHO Maternal Child Epidemiology Estimation collaboration country-specific of pneumonia meningitis mortality morbidity 2015, applied pneumococcal Hib cause-specific...
The human genome is characterised by many runs of homozygous genotypes, where identical haplotypes were inherited from each parent. length run determined partly the number generations since common ancestor: offspring cousin marriages have long homozygosity (ROH), while numerous shorter tracts relate to shared ancestry tens and hundreds ago. Human populations experienced a wide range demographic histories hold diverse cultural attitudes consanguinity. In global population dataset, genome-wide...
All immunoglobulin G molecules carry N-glycans, which modulate their biological activity. Changes in N-glycosylation of IgG associate with various diseases and affect the activity therapeutic antibodies intravenous immunoglobulins. We have developed a novel 96-well protein monolithic plate used it to rapidly isolate from plasma 2298 individuals three isolated human populations. N-glycans were released by PNGase F, labeled 2-aminobenzamide analyzed hydrophilic interaction chromatography...
The recent series of reviews conducted within the Global Action Plan for Pneumonia and Diarrhoea (GAPPD) addressed epidemiology two deadly diseases at global regional level; it also estimated effectiveness interventions, barriers to achieving high coverage main implications health policy. aim this paper is provide estimates childhood pneumonia country level. This should allow national policy-makers stakeholders implement proposed policies in World Health Organization (WHO) UNICEF member...
Background The phecode system was built upon the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) for phenome-wide association studies (PheWAS) using electronic health record (EHR). Objective goal this paper to develop and perform an initial evaluation maps from 10th Revision (ICD-10) (ICD-10-CM) codes phecodes. Methods We mapped ICD-10 ICD-10-CM phecodes a number methods resources, such as concept relationships explicit mappings Centers Medicare...