A5112265453- Cytokine Signaling Pathways and Interactions
- Retinoids in leukemia and cellular processes
- Nuclear Receptors and Signaling
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Hormonal Regulation and Hypertension
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Bioinformatics and Genomic Networks
- Immune Cell Function and Interaction
- Gene expression and cancer classification
- Pharmacological Effects of Natural Compounds
- Genetic Mapping and Diversity in Plants and Animals
- Inflammatory mediators and NSAID effects
- Lymphoma Diagnosis and Treatment
- Dermatology and Skin Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Gut microbiota and health
- Ferroptosis and cancer prognosis
- Adenosine and Purinergic Signaling
University of Chicago
2013-2025
PharmacoGenetics (China)
2011
T cell infiltration of solid tumors is associated with favorable patient outcomes, yet the mechanisms underlying variable immune responses between individuals are not well understood. One possible modulator could be intestinal microbiota. We compared melanoma growth in mice harboring distinct commensal microbiota and observed differences spontaneous antitumor immunity, which were eliminated upon cohousing or after fecal transfer. Sequencing 16S ribosomal RNA identified Bifidobacterium as...
Understanding the genetic architecture of gene expression traits is key to elucidating underlying mechanisms complex traits. Here, for first time, we perform a systematic survey heritability and distribution effect sizes across all representative tissues in human body. We find that local h2 can be relatively well characterized with 59% expressed genes showing significant (FDR < 0.1) DGN whole blood cohort. However, current sample (n ≤ 922) do not allow us compute distal h2. Bayesian Sparse...
Transplantation is the only cure for end-stage organ failure, but without immunosuppression, T cells rapidly reject allografts. While genetic disparities between donor and recipient are major determinants of kinetics transplant rejection, little known about contribution environmental factors. Because colonized organs have worse outcome than sterile organs, we tested influence host microbiota on skin rejection. Compared with untreated conventional mice, pretreatment donors recipients...
High-confidence prediction of complex traits such as disease risk or drug response is an ultimate goal personalized medicine. Although genome-wide association studies have discovered thousands well-replicated polymorphisms associated with a broad spectrum traits, the combined predictive power these associations for any given trait generally too low to be clinical relevance. We propose novel systems approach prediction, which leverages and integrates similarity in genetic, transcriptomic,...
Based on the notion that hypomorphic germline genetic variants are linked to autoimmune diseases, we reasoned novel targets for cancer immunotherapy might be identified through associated with greater T-cell infiltration into tumors. Here, report while investigating polymorphisms a tumor immune gene signature, PKCδ as candidate. Genetic deletion of in mice resulted improved endogenous antitumor immunity and increased efficacy anti-PD-L1. Single-cell RNA sequencing revealed myeloid cell...
<div>Abstract<p>Based on the notion that hypomorphic germline genetic variants are linked to autoimmune diseases, we reasoned novel targets for cancer immunotherapy might be identified through associated with greater T-cell infiltration into tumors. Here, report while investigating polymorphisms a tumor immune gene signature, protein kinase C delta (PKCδ) as candidate. Genetic deletion of <i>Prkcd</i> in mice resulted improved endogenous antitumor immunity and...
<p>SNP alleles correlate with an M1/M2 gene signature score</p>
<p>SNP alleles correlate with <i>PRKCD</i> expression and the 160 gene signature score</p>
<p>Hematopoietic loss of PKCδ leads to an altered immune response</p>
<p>Supplemental Table 4</p>
<p>Supplemental Table 6</p>
<p>Supplemental Table 2</p>
<p>Supplemental Table 3</p>
<p>Supplemental Table 5</p>
<p>Hematopoietic loss of PKCδ via Vav1-iCre delays tumor growth and alters inflammatory gene expression in alternative “2C1”Prkcdfl/fl founder.</p>
<p>Overview of the targeting strategy employed for creation <i>Prkcd</i> conditional knockout mice</p>
<p>Supplemental Table 7</p>
<p>T cell priming is unaltered with hematopoietic loss of PKCδ</p>
<p>Hematopoietic loss of PKCδ via Vav1-iCre delays tumor growth and alters inflammatory gene expression in “2B4”Prkcdfl/fl founder.</p>
<p>Supplemental Table 1</p>
<p>Loss of PKCδ in myeloid cells delays tumor growth and is further delayed with anti-PD-L1 therapy multiple Prkcdfl/fl founders.</p>
<p>GSEA reveals many macrophage-related gene sets that are enriched in the C1qa DEG list.</p>
Little is known about genetic contributors to higher than usual warfarin dose requirements, particularly for African Americans. This study tested the hypothesis that γ-glutamyl carboxylase (GGCX) genotype contributes requirements greater 7.5 mg/day in an American population.