A5034270688- Cytokine Signaling Pathways and Interactions
- Retinoids in leukemia and cellular processes
- Nuclear Receptors and Signaling
- Epigenetics and DNA Methylation
- Drug Transport and Resistance Mechanisms
- Photochemistry and Electron Transfer Studies
- Immune Cell Function and Interaction
- Adenosine and Purinergic Signaling
- Diversity and Career in Medicine
- Dental Education, Practice, Research
- Global Health Workforce Issues
- Innovations in Medical Education
- Surgical Simulation and Training
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced Chemical Physics Studies
- Simulation-Based Education in Healthcare
- Mass Spectrometry Techniques and Applications
University of Chicago
2025
Lawrence Berkeley National Laboratory
2014
We present kinematically complete measurements of the photo-double-ionization ethylene (double CC bond) and acetylene (triple hydrocarbons just above double-ionization threshold. discuss results in terms coincident kinetic energy photoelectrons nuclear kinetic-energy release recoiling ions. have incorporated quantum chemistry calculations to interpret which electronic states dication been populated trace various subsequent fragmentation channels. suggest pathways that involve ground excited...
Based on the notion that hypomorphic germline genetic variants are linked to autoimmune diseases, we reasoned novel targets for cancer immunotherapy might be identified through associated with greater T-cell infiltration into tumors. Here, report while investigating polymorphisms a tumor immune gene signature, PKCδ as candidate. Genetic deletion of in mice resulted improved endogenous antitumor immunity and increased efficacy anti-PD-L1. Single-cell RNA sequencing revealed myeloid cell...
<div>Abstract<p>Based on the notion that hypomorphic germline genetic variants are linked to autoimmune diseases, we reasoned novel targets for cancer immunotherapy might be identified through associated with greater T-cell infiltration into tumors. Here, report while investigating polymorphisms a tumor immune gene signature, protein kinase C delta (PKCδ) as candidate. Genetic deletion of <i>Prkcd</i> in mice resulted improved endogenous antitumor immunity and...
<p>SNP alleles correlate with an M1/M2 gene signature score</p>
<p>SNP alleles correlate with <i>PRKCD</i> expression and the 160 gene signature score</p>
<p>Hematopoietic loss of PKCδ leads to an altered immune response</p>
<p>Supplemental Table 4</p>
<p>Supplemental Table 6</p>
<p>Supplemental Table 2</p>
<p>Supplemental Table 3</p>
<p>Supplemental Table 5</p>
<p>Hematopoietic loss of PKCδ via Vav1-iCre delays tumor growth and alters inflammatory gene expression in alternative “2C1”Prkcdfl/fl founder.</p>
<p>Overview of the targeting strategy employed for creation <i>Prkcd</i> conditional knockout mice</p>
<p>Supplemental Table 7</p>
<p>T cell priming is unaltered with hematopoietic loss of PKCδ</p>
<p>Hematopoietic loss of PKCδ via Vav1-iCre delays tumor growth and alters inflammatory gene expression in “2B4”Prkcdfl/fl founder.</p>
<p>Supplemental Table 1</p>
<p>Loss of PKCδ in myeloid cells delays tumor growth and is further delayed with anti-PD-L1 therapy multiple Prkcdfl/fl founders.</p>
<p>GSEA reveals many macrophage-related gene sets that are enriched in the C1qa DEG list.</p>