A5069812856- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Glycosylation and Glycoproteins Research
- Complement system in diseases
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- Nanoparticle-Based Drug Delivery
- Gut microbiota and health
- Immune Cell Function and Interaction
- Blood Coagulation and Thrombosis Mechanisms
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cell Adhesion Molecules Research
- Mycobacterium research and diagnosis
- Platelet Disorders and Treatments
- Radiopharmaceutical Chemistry and Applications
- Chemokine receptors and signaling
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Drug Transport and Resistance Mechanisms
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Bone health and treatments
Boehringer Ingelheim (Austria)
2022-2024
Boehringer Ingelheim (Germany)
2023
University of Chicago
2013-2016
Universidad de Navarra
2013-2014
Fundación Instituto Valenciano de Oncología
2013
Clinica Universidad de Navarra
2010
Lund University
2009
T cell infiltration of solid tumors is associated with favorable patient outcomes, yet the mechanisms underlying variable immune responses between individuals are not well understood. One possible modulator could be intestinal microbiota. We compared melanoma growth in mice harboring distinct commensal microbiota and observed differences spontaneous antitumor immunity, which were eliminated upon cohousing or after fecal transfer. Sequencing 16S ribosomal RNA identified Bifidobacterium as...
Cigarette smoking is strongly correlated with the onset of lung cancer. Nicotine, a major component in cigarette smoke, has been found to promote tumor growth and angiogenesis, as well protect cancer cells from apoptosis. Among all cases, small cell (SCLC) almost exclusively smokers; metastasis chemoresistance are main reasons for high mortality rates associated SCLC. Retrospective studies have shown that patients tobacco-related cancers who continue smoke after their diagnosis display lower...
Abstract Background: Cytologic examination of specimens obtained from the respiratory tract is a lung cancer diagnostic procedure with high specificity but moderate sensitivity. The use molecular biomarkers may enhance sensitivity cytologic in detection cancer. Methods: Complement factor H, protein secreted by cells, was quantified series bronchoalveolar lavage supernatants patients and nonmalignant diseases. Albumin, total content, hemoglobin were also analyzed. Results validated...
The authors report a novel approach for enhancing the oral absorption of paclitaxel (PTX) by encapsulation in poly(anhydride) nanoparticles (NPs) containing cyclodextrins and poly(ethylene glycol).Formulations were prepared using solvent displacement method. Subsequently, pharmacokinetics organ distribution assays evaluated after administration into C57BL/6J mice. In addition, antitumor efficacy studies performed subcutaneous tumor model Lewis lung carcinoma.PTX-loaded NPs displayed sizes...
Advanced-stage gastrointestinal cancers represent a high unmet need requiring new effective therapies. We investigated the antitumor activity of novel T cell-engaging antibody (B7-H6/CD3 ITE) targeting B7-H6, tumor-associated antigen that is expressed in tumors.Membrane proteomics and IHC analysis identified B7-H6 as tumor tissues with no to very little expression normal tissues. The mode action B7-H6/CD3 ITE was evaluated vitro coculture assays, humanized mouse models, colorectal cancer...
Colorectal cancer (CRC) is one of the most common cancers worldwide and demands more effective treatments. We sought to identify tumor selective CRC antigens their therapeutic potential for cytotoxic T-cell targeting by transcriptomic immunohistochemical analysis. LY6G6D was identified as a selectively expressed antigen, mainly in microsatellite stable (MSS) subtype. A specific anti LY6G6D/CD3 T cell engager (TcE) generated demonstrated potent killing activation vitro. Ex vivo treatment...
<h3>Background</h3> Fibroblast activating protein (FAP) is an attractive target for therapeutic intervention being mainly expressed in malignant tissues. Previous studies have targeted FAP using a variety of methods yet failed clinics. <h3>Methods</h3> Here, we utilize FAP-targeted T cell engager (TcE) KPCY tumor models to recapitulate pre-clinical environment. The use FAP-TcE efficiently depleted FAP+ fibroblasts <i>in vitro</i> and vivo</i> from tumors. <h3>Results</h3> This resulted...
Meeting abstracts T cell infiltration of solid tumors is found in a subset cancer patients and associated with favorable patient outcomes. This demonstrates the capacity immune system to mount protective anti-tumor responses some patients, yet underlying mechanisms
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
<p>Supplementary Figure 1 (A) OGAP® Screen of tumor and non-tumorous (normal, non-diseased tissues). (B) B7-H6 mRNA expression in gastrointestinal cancer tissues (TCGA). Supplementary 2 on cell lines 3 Influence B7-H6/CD3 ITE the B7-H6-induced activation NK-92® MI cells. 4 Pharmacokinetic profile NOG mice.</p>
<p>Supplementary Figure 1 (A) OGAP® Screen of tumor and non-tumorous (normal, non-diseased tissues). (B) B7-H6 mRNA expression in gastrointestinal cancer tissues (TCGA). Supplementary 2 on cell lines 3 Influence B7-H6/CD3 ITE the B7-H6-induced activation NK-92® MI cells. 4 Pharmacokinetic profile NOG mice.</p>
<div>AbstractPurpose:<p>Advanced-stage gastrointestinal cancers represent a high unmet need requiring new effective therapies. We investigated the antitumor activity of novel T cell–engaging antibody (B7-H6/CD3 ITE) targeting B7-H6, tumor-associated antigen that is expressed in tumors.</p>Experimental Design:<p>Membrane proteomics and IHC analysis identified B7-H6 as tumor tissues with no to very little expression normal tissues. The mode action B7-H6/CD3 ITE was...
<div>AbstractPurpose:<p>Advanced-stage gastrointestinal cancers represent a high unmet need requiring new effective therapies. We investigated the antitumor activity of novel T cell–engaging antibody (B7-H6/CD3 ITE) targeting B7-H6, tumor-associated antigen that is expressed in tumors.</p>Experimental Design:<p>Membrane proteomics and IHC analysis identified B7-H6 as tumor tissues with no to very little expression normal tissues. The mode action B7-H6/CD3 ITE was...
<div>Abstract<p><b>Background</b>: Cytologic examination of specimens obtained from the respiratory tract is a lung cancer diagnostic procedure with high specificity but moderate sensitivity. The use molecular biomarkers may enhance sensitivity cytologic in detection cancer.</p><p><b>Methods</b>: Complement factor H, protein secreted by cells, was quantified series bronchoalveolar lavage supernatants patients and nonmalignant diseases. Albumin,...
<div>Abstract<p><b>Background</b>: Cytologic examination of specimens obtained from the respiratory tract is a lung cancer diagnostic procedure with high specificity but moderate sensitivity. The use molecular biomarkers may enhance sensitivity cytologic in detection cancer.</p><p><b>Methods</b>: Complement factor H, protein secreted by cells, was quantified series bronchoalveolar lavage supernatants patients and nonmalignant diseases. Albumin,...