A5051485828- Lung Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Research Studies
- Respiratory Support and Mechanisms
- RNA modifications and cancer
- Pleural and Pulmonary Diseases
- Epigenetics and DNA Methylation
- Medical Imaging Techniques and Applications
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Cancer Genomics and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Nitric Oxide and Endothelin Effects
- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
- Complement system in diseases
- Global Cancer Incidence and Screening
- Asthma and respiratory diseases
- Eicosanoids and Hypertension Pharmacology
- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Bone health and osteoporosis research
Icahn School of Medicine at Mount Sinai
2021-2025
Mount Sinai Medical Center
2025
Clinica Universidad de Navarra
2015-2024
Mount Sinai Hospital
2022-2024
Cornell University
2023
Mount Sinai Hospital
2023
Navarre Institute of Health Research
2018-2023
Centro de Investigación Biomédica en Red de Cáncer
2018-2023
Alta Bates Summit Medical Center
2023
Universidad de Navarra
2008-2021
Patients with chronic obstructive pulmonary disease (COPD) are afflicted by comorbidities. Few studies have prospectively evaluated COPD comorbidities and mortality risk.To evaluate risk.We followed 1,664 patients in five centers for a median of 51 months. Systematically, 79 were recorded. We calculated risk using Cox proportional hazard, developed graphic representation the prevalence strength association to form "comorbidome". A comorbidity index (COPD specific test [COTE]) was constructed...
Little is known about the clinical factors associated with development of lung cancer in patients chronic obstructive pulmonary disease (COPD), although airway obstruction and emphysema have been identified as possible risk factors.To explore incidence, histologic type, diagnosis a cohort outpatients COPD attending clinic.A 2,507 without initial or radiologic evidence was followed median 60 months(30–90). At baseline, anthropometrics, smoking history, function,and body composition were...
Oxygen (O2) may regulate pulmonary vascular resistance through changes in endothelial nitric oxide (NO) production. To determine whether constitutive NO synthase (cNOS) is regulated by O2, we assessed cNOS expression and activity bovine artery cells exposed to different concentrations of O2. In a time-dependent manner, O2 concentration from 95 3% produced progressive decrease mRNA protein levels resulting 4.8- 4.3-fold reductions after 24h, respectively. This correlated with as determined...
Lobectomy is the standard of care for stage IA lung cancer. Some small retrospective studies have suggested similar results after limited resection tumors < or =2 cm in size. The objective study was to compare survival lobectomy and among Medicare patients with cancer.Using Surveillance, Epidemiology, End Results registry, linked records, we identified 1165 cases I cancer size that underwent (segmentectomy wedge resection). We used logistic regression determine propensity scores undergoing...
Multimorbidity frequently affects the ageing population and their co-existence may not occur at random. Understanding interactions that with clinical variables could be important for disease screening management. In a cohort of 1969 chronic obstructive pulmonary (COPD) patients 316 non-COPD controls, we applied network-based analysis to explore associations between multiple comorbidities. Clinical characteristics (age, degree obstruction, walking, dyspnoea, body mass index) 79 comorbidities...
Rationale: Lung cancer screening using computed tomography (CT) is effective in detecting lung early stages. Concerns regarding false-positive rates and unnecessary invasive procedures have been raised. Objective: To study the efficiency of a protocol spiral CT F-18-fluorodeoxyglucose positron emission (FDG-PET). Methods: High-risk individuals underwent with annual CTs. Follow-up CTs were done for noncalcified nodules 5 mm or greater, FDG-PET was 10 larger smaller (> 7 mm), growing nodules....
There is a medical need for diagnostic biomarkers in lung cancer. We evaluated the performance of complement activation fragments.We assessed four bronchial epithelial and seven cancer cell lines. C4d, degradation product activation, was determined 90 primary tumors; bronchoalveolar lavage supernatants from patients with (n = 50) nonmalignant respiratory diseases 22); plasma samples advanced early 84) subjects inflammatory 133), asymptomatic individuals enrolled computed tomography screening...
Patients with chronic obstructive pulmonary disease (COPD) are at high risk for lung cancer (LC) and represent a potential target to improve the diagnostic yield of screening programs.To develop predictive score LC patients COPD.The Pamplona International Early Lung Cancer Detection Program (P-IELCAP) Pittsburgh Screening Study (PLuSS) databases were analyzed. Only COPD on spirometry included. By logistic regression we determined which factors independently associated in PLuSS developed...
The purpose of this study was to compare the effects Small-Sided Games (SSG) vs. Interval Training (IT) in soccer training on aerobic fitness and physical enjoyment youth elite players during last 8 weeks season. Seventeen U-16 male (age = 15.5 ± 0.6 years, 8.5 years experience) a Spanish First Division club academy were randomized 2 different groups for 6 weeks: SSG group (n 9) IT 8). In addition usual technical tactical sessions competitive games, performed 11 with SSGs, whereas same...
The objectives of this study were to determine the frequency lung cancers associated with a discrete cystic airspace and characterize morphologic pathologic features cancer airspace.We reviewed all diagnosed cases resulting from baseline screening (n=595) annual (n=111) in International Early Lung Cancer Action Program identify those abutting or wall airspace. We also specimens.A total 26 identified Of these, 13 at (13/595, 2%) (13/111, 12%), which was significant (p<0.0001). median...
This multicentre, blinded, sham-controlled study was performed to assess the safety and effectiveness of bronchial valve therapy using a bilateral upper lobe treatment approach without goal lobar atelectasis. Patients with predominant severe emphysema were randomised bronchoscopy (n=37) or (n=36) IBV Valves for 3-month blinded phase. A positive responder defined as having both ≥4-point improvement in St George's Respiratory Questionnaire (SGRQ) volume shift measured by quantitative computed...
Abstract Purpose: Lung cancer remains as the leading cause of cancer-related death worldwide, mainly due to late diagnosis. Cytology is gold-standard method for lung diagnosis in minimally invasive respiratory samples, despite its low sensitivity. We aimed identify epigenetic biomarkers with clinical utility minimally/noninvasive specimens improve accuracy current technologies. Experimental Design: The identification novel stage I tumors was accomplished using an integrative genome-wide...
Uncontrolled pilot studies demonstrated promising results of endoscopic lung volume reduction using emphysematous sealant (ELS) in patients with advanced, upper lobe predominant emphysema. We aimed to evaluate the safety and efficacy ELS a randomised controlled setting.Patients were plus medical treatment or alone. Despite early termination for business reasons inability assess primary 12-month end-point, 95 out 300 successfully randomised, providing sufficient data 3- 6-month analysis.57...
Rationale: Lung cancer (LC) screening using low-dose chest computed tomography is now recommended in several guidelines the National Screening Trial (NLST) entry criteria (age, 55–74; ≥30 pack-years; tobacco cessation within previous 15 yr for former smokers). Concerns exist about their lack of sensitivity.Objectives: To evaluate performance NLST two different LC studies from Europe and United States, to explore effect emphysema as a complementary criterion.Methods: Participants Pamplona...
<h3>Background</h3> The Global Obstructive Lung Disease (GOLD) 2011 revision recommends the multidimensional assessment of COPD including comorbidities and has developed a disease categories system (ABCD) attempting to implement this strategy. added value provided by quantifying integrating them indices not been explored. <h3>Objective</h3> Compare prognostic GOLD ABCD versus BMI, Obstruction, Dyspnea, Exercise (BODE) index, explore evaluation assessment. <h3>Methods</h3> From patients who...
Aging is an important risk factor for most chronic diseases. Patients with COPD develop more comorbidities than non-COPD subjects. We hypothesized that the development of characteristically affecting elderly occur at earlier age in subjects diagnosis COPD.
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Background The low-dose CT (≤3 mGy) screening report of 1000 Early Lung Cancer Action Program (ELCAP) participants in 1999 led to the International ELCAP (I-ELCAP) collaboration, which enrolled 31 567 annual between 1992 and 2005. In 2006, I-ELCAP investigators reported 10-year lung cancer-specific survival 80% for 484 diagnosed with a first primary cancer through screening, high frequency clinical stage I (85%). Purpose To update cure rate by determining 20-year expanded cohort. Materials...