A5091143463- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Atomic and Subatomic Physics Research
- Respiratory Support and Mechanisms
- Advanced Radiotherapy Techniques
- Pleural and Pulmonary Diseases
- Lung Cancer Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Salivary Gland Tumors Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Head and Neck Cancer Studies
- Airway Management and Intubation Techniques
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Inhalation and Respiratory Drug Delivery
- Optics and Image Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Astronomical Observations and Instrumentation
- Image Processing Techniques and Applications
- Lymphoma Diagnosis and Treatment
FirstHealth of the Carolinas
2017-2024
Anderson Orthopaedic Clinic
2014-2023
Pulmonary Associates
2023
Health First
2022
Veracyte (United States)
2017
British Association for Immediate Care Scotland
2015
BASilar artery International Cooperation Study
2015
Vanderbilt University
2014
Cambridge Consultants (United Kingdom)
1989
Electromagnetic navigation bronchoscopy (ENB) is a minimally invasive technology that guides endoscopic tools to pulmonary lesions. ENB has been evaluated primarily in small, single-center studies; thus, the diagnostic yield generalizable setting unknown.NAVIGATE prospective, multicenter, cohort study using superDimension system (Medtronic, Minneapolis, Minnesota). In this United States analysis, 1215 consecutive subjects were enrolled at 29 academic and community sites from April 2015...
Electromagnetic navigation bronchoscopy (ENB) has been widely adopted as a guidance technique for biopsy of peripheral lung nodules. However, ENB is limited by the lack real-time confirmation devices. Intraprocedural cone-beam computed tomography (CBCT) imaging can be utilized to assess or confirm location The aim this study determine safety and diagnostic yield (DY) image fusion intraprocedural CBCT data with live fluoroscopy (augmented fluoroscopy) during ENB-guided nodules.Data from 75...
Uncontrolled pilot studies demonstrated promising results of endoscopic lung volume reduction using emphysematous sealant (ELS) in patients with advanced, upper lobe predominant emphysema. We aimed to evaluate the safety and efficacy ELS a randomised controlled setting.Patients were plus medical treatment or alone. Despite early termination for business reasons inability assess primary 12-month end-point, 95 out 300 successfully randomised, providing sufficient data 3- 6-month analysis.57...
Electromagnetic navigation bronchoscopy (ENB) is an image-guided, minimally invasive approach that uses a flexible catheter to access pulmonary lesions.
Traditional bronchoscopy provides limited approach to peripheral nodules. Shape-sensing robotic-assisted (SSRAB, Ion™ Endoluminal System) is a new tool for minimally invasive nodule biopsy. We sought answer the research question: Does SSRAB facilitate sampling of pulmonary nodules during bronchoscopists' initial experience?The lead-in stage multicenter, single-arm, prospective evaluation Ion System (PRECIsE) described. Enrolled subjects ≥ 18 years old had recent computed tomography evidence...
Background: Image-guided percutaneous thermal ablation is an established treatment option for early-stage lung cancer in medically inoperable patients but carries a high risk of pleura-related complications, particularly pneumothorax. Objective: This study aimed to determine if image-guided transbronchial microwave (tMWA) feasible approach treat peripheral stage 1 cancer. Method: A prospective, single-arm, multicenter sought enroll 40 adults who were or declined surgery tumors (≤20 mm)....
The use and availability of diverse advanced X-ray based imaging guidance systems in the field interventional pulmonology are rapidly growing. This popularity links inextricably to an increase ionizing radiation use. Knowing is hazardous, knowledge competent important. globally implemented As Low Reasonably Achievable (ALARA) principle demands careful attention minimize exposure while achieving precise goals intervention therein. To allow targeted weighing risk against reward using...
Background: Computed tomography-to-body divergence caused by respiratory motion, atelectasis, diaphragmatic motion and other factors is an obstacle to peripheral lung biopsies. We examined a conventional ventilation strategy versus navigation protocol (LNVP) optimized for intraprocedural 3-dimensional image acquisition bronchoscopic biopsy of nodules. Methods: A retrospective, single center study was conducted in consecutive subjects with lesions measuring <30 mm. Effects strategies...
Significance Mutations in SMARCAL1, a DNA remodeling protein fundamental to genome integrity during replication, lead the developmental disorder Schimke immuno-osseous dysplasia (SIOD). SMARCAL1-deficient cells exhibit collapsed replication forks, S-phase cell cycle arrest, increased chromosomal breaks, hypersensitivity genotoxic agents, and instability. SMARCAL1 facilitates restart by catalyzing ATP-dependent fork regression branch migration, mechanism of which is poorly understood. Here we...
PURPOSE Guidelines advocate molecular profiling in the evaluation of advanced non–small-cell lung cancer (NSCLC) and support use plasma circulating tumor DNA (ctDNA)-based for patients with insufficient tissue. Thorough prospective clinical validation studies next-generation sequencing (NGS)-based ctDNA assays are lacking. We report multicentered InVision assay untreated NSCLC. METHODS A total 264 NSCLC were prospectively recruited, their was analyzed using a NGS detection genomic...
Background: Navigational bronchoscopy has improved upon traditional to identify suspicious pulmonary lesions, but wide variability exists in the diagnostic yield of various modalities. The aim this study was measure localization accuracy and a novel endobronchial augmented fluoroscopic navigation system (first-generation LungVision system) for peripheral lesions (PPLs). Methods: This prospective single-center included adults undergoing guided evaluate PPLs. Preprocedure computed tomography...
Background: The diagnostic yield of electromagnetic navigation bronchoscopy (ENB) is impacted by biopsy tool strategy and rapid on-site evaluation (ROSE) use. This analysis evaluates usage patterns, accuracy, safety ROSE in a multicenter study. Methods: NAVIGATE (NCT02410837) ENB using the superDimension system (versions 6.3 to 7.1). 1-year included 1215 prospectively enrolled subjects at 29 United States sites. Included herein are 416 who underwent ENB-aided single lung lesion positive for...
Fiducial markers (FMs) help direct stereotactic body radiation therapy (SBRT) and localization for surgical resection in lung cancer management. We report the safety, accuracy, practice patterns of FM placement utilizing electromagnetic navigation bronchoscopy (ENB).NAVIGATE is a global, prospective, multicenter, observational cohort study ENB using superDimension™ system. This prospectively collected subgroup analysis presents patient demographics, procedural characteristics, 1-month...
Background: Electromagnetic navigation bronchoscopy (ENB) aids in lung lesion biopsy. However, anatomic divergence between the preprocedural computed tomography (CT) and actual bronchial anatomy during procedure can limit localization accuracy. An advanced ENB system has been designed to mitigate CT-to-body using a tomosynthesis-based software algorithm that enhances nodule visibility allows for intraprocedural local registration. Materials Methods: A prospective, 2-center study was...
Abstract Introduction Electromagnetic navigation bronchoscopy (ENB)‐guided pleural dye marking is useful to localize small peripheral pulmonary nodules for sublobar resection. Objective To report findings on the use of ENB‐guided among participants in NAVIGATE study. Methods a prospective, multicentre, global and observational cohort study ENB patients with lung lesions. The current subgroup prespecified 1‐month interim analysis United States cohort. Results full includes 1215 subjects from...