A5059713279- DNA Repair Mechanisms
- Enzyme Structure and Function
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Bacterial Genetics and Biotechnology
- Metal-Catalyzed Oxygenation Mechanisms
- Protein Structure and Dynamics
- Nitric Oxide and Endothelin Effects
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- PARP inhibition in cancer therapy
- Monoclonal and Polyclonal Antibodies Research
- Bacteriophages and microbial interactions
- Advanced biosensing and bioanalysis techniques
- Photosynthetic Processes and Mechanisms
- Biochemical and Molecular Research
- Cancer-related Molecular Pathways
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- Glutathione Transferases and Polymorphisms
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Amyotrophic Lateral Sclerosis Research
The University of Texas MD Anderson Cancer Center
2016-2025
Lawrence Berkeley National Laboratory
2016-2025
The University of Texas Health Science Center at Houston
2022
Massachusetts Institute of Technology
1998-2022
Anderson University - South Carolina
2020
Washington University in St. Louis
2017
University of California, Santa Cruz
2017
Molecular Biology Consortium
2017
Scripps Research Institute
2006-2015
QB3
2013
Crystal structures of the murine cytokine-inducible nitric oxide synthase oxygenase dimer with active-center water molecules, substrate l -arginine ( -Arg), or product analog thiocitrulline reveal how dimerization, cofactor tetrahydrobiopterin, and -Arg binding complete catalytic center for synthesis essential biological signal cytotoxin oxide. Pterin refolds central interface region, recruits new structural elements, creates a 30 angstrom deep channel, causes 35° helical tilt to expose heme...
A major challenge in structural biology is to characterize structures of proteins and their assemblies solution. At low resolution, such a characterization may be achieved by small angle x-ray scattering (SAXS). Because SAXS analyses often require comparing profiles calculated from many atomic models against those determined experiment, rapid accurate profile computation molecular needed. We developed fast open-source (FoXS) for computation. To match the experimental within noise, FoXS...
Abstract Unstructured proteins, RNA or DNA components provide functionally important flexibility that is key to many macromolecular assemblies throughout cell biology. As objective, quantitative experimental measures of and disorder in solution are limited, small angle scattering (SAS), particular X‐ray (SAXS), provides a critical technology assess as well shape assembly. Here, we consider the Porod‐Debye law powerful tool for detecting biopolymer SAS experiments. We show region...
Small Angle X-ray Scattering (SAXS) is an increasingly common and useful technique for structural characterization of molecules in solution. A SAXS experiment determines the scattering intensity a molecule as function spatial frequency, termed profile. Here, we describe three web servers modeling atomic structures based on profiles. FoXS (Fast X-Ray Scattering) rapidly computes profile given atomistic model fits it to experimental FoXSDock docks two rigid protein their complex. MultiFoXS...