A5080277525- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Head and Neck Cancer Studies
- Ultrasound in Clinical Applications
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Esophageal Cancer Research and Treatment
- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Microbial Inactivation Methods
- Brain Metastases and Treatment
- Actinomycetales infections and treatment
- Pleural and Pulmonary Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Obstructive Sleep Apnea Research
- Voice and Speech Disorders
Radboud University Nijmegen
2017-2025
Radboud University Medical Center
2017-2025
University Medical Center
2024
Pulmonary Associates
2020-2021
Radboud Institute for Molecular Life Sciences
2020
University of Twente
2018
Bronchoscopic diagnosis of small peripheral lung lesions suspected cancer remains a challenge. A successful endobronchial comprises navigation, confirmation, and tissue acquisition. In all steps, 3-dimensional information is essential. Cone-beam computed tomography (CBCT) imaging can provide augmented fluoroscopy imaging. We assessed whether CBCT improve navigation by 2 clinical workflows with cross-over design: (1) primary radial ultrasound mini probe imaging-based approach (2)...
Background: The endobronchial diagnosis of peripheral lung lesions suspected cancer remains a challenge from navigation as well an adequate tissue sampling perspective. Cone-beam computed tomography (CBCT) guidance is relatively new technology and allows for 3-dimensional imaging confirmation biopsy guidance, but, also involves radiation. This study investigates how radiation exposure diagnostic accuracy in the CBCT-guided bronchoscopy evolves with increasing experience, and, specific...
The use and availability of diverse advanced X-ray based imaging guidance systems in the field interventional pulmonology are rapidly growing. This popularity links inextricably to an increase ionizing radiation use. Knowing is hazardous, knowledge competent important. globally implemented As Low Reasonably Achievable (ALARA) principle demands careful attention minimize exposure while achieving precise goals intervention therein. To allow targeted weighing risk against reward using...
ABSTRACT Background and Methods Surgery remains the standard of care for non‐small cell lung cancer (NSCLC) but is applicable to ≤ 30% patients. Pulsed Electric Fields (PEF) ablation uses short‐duration, high‐voltage electrical pulses induce death without relying on thermal mechanisms. Safety findings are reported from a two‐arm, non‐randomized, study evaluating use PEF in patients with early‐stage NSCLC. energy was delivered bronchoscopically or percutaneously 36 suspected confirmed NSCLC...
Advanced technological aids are frequently used to improve outcome of transbronchial diagnostics for peripheral pulmonary lesions. Even when lesion access has been confirmed by 3D imaging, obtaining an accurate tissue sample however remains difficult. In this single institution study, we evaluate the comparative accuracy different sampling methodologies and rapid on-site evaluation cytopathology (ROSE) in navigation bronchoscopy cases where imaging catheter have accurately accessed...
ObjectivesLymph node staging in patients with non-small cell lung cancer is crucial for determining prognosis and treatment. Our objective was to evaluate the clinical- pathological agreement of guideline-concordant nodal resectable NSCLC assess occurrence distribution occult lymph metastases (OLM).Materials methodsIn a retrospective single center cohort study (n = 390), we analyzed all surgically treated from January 2015 until April 2019. Patients were classified into sub-groups (1)...
<b><i>Background:</i></b> In lung cancer staging, mediastinal lymph nodes are currently aspirated using endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) based on size and FDG-PET avidity. EBUS strain elastography (SE) is a new technique that may help predict the presence of malignancy. However, standardized assessment strategy for EBUS-SE measurement lacking. <b><i>Objectives:</i></b> The aim this study was to determine...
<b><i>Background:</i></b> Systematic assessment of lymph node status by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is indicated in (suspected) lung cancer. Sampling herein guided nodal size and FDG-PET characteristics. Ultrasound strain elastography (SE) might further improve risk stratification. By imaging tissue deformation over time, SE computes relative strain. In several tissues, a lower (deformation) has been associated with...
Rapid on-site evaluation (ROSE) of cytopathology plays an important role in determining whether representative samples have been taken during navigation bronchoscopy. With touch imprint cytology (TIC), histologic can be assessed using ROSE. Although advised by guidelines, there almost no studies on the performance TIC The objective this study was to evaluate value TIC-ROSE (forceps/cryobiopsy) combination with conventional ROSE (cytology needle/brush).
Cone beam CT based Navigation Bronchoscopy (CBCT-NB) has predominantly been investigated as a diagnostic tool in (suspected) primary lung cancers. Small metastatic lesions are clinically considered more challenging to diagnose, but no study explored the yield of navigation bronchoscopy patients with pulmonary (ML) compared cancers (PL), correcting for known lesion characteristics affecting yield.
Assess the feasibility of a prototype image reconstruction algorithm in correcting motion artifacts cone-beam computed tomography (CBCT) scans interventional instruments lung.
Introduction Cone Beam CT-guided Navigation Bronchoscopy (CBCT-NB) with Augmented Fluoroscopy (AF) guidance represents a minimally invasive endobronchial technique for diagnosing small, peripheral pulmonary lesions. This approach is characterized by its high diagnostic accuracy and low complication risk. Current pilot trials are exploring the application of localized therapies using this innovative approach. reportaims to provide detailed procedural guide performing CBCT-NB AF as only tool...
To the Editors: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), increasingly used for pathological confirmation of clinical suspect sarcoidosis, has a 20% failure rate in detection granulomas.1-4 Clinical experience and anecdotal reports suggest that at least some non-diagnostic EBUS-TBNA sarcoidosis may be caused by presence lymph nodes with extensive fibrosis.2, 5 We assessed role EBUS-strain elastography (EBUS-SE) patients enrolled Nijmegen (The Netherlands)...
Objectives To determine if cone beam CT-guided navigation bronchoscopy (CBCT-NB) is a cost-effective diagnostic procedure in patients with pulmonary nodule (PN) an intermediate risk for lung cancer. Materials and methods Two decision analytical models were developed to compare the long-term costs, survival quality of life. In first model, CBCT-NB was compared transthoracic needle biopsy (TTNB) TTNB eligible patients. second direct treatment (without pathology proven cancer) whom not...
<b><i>Background:</i></b> Endoscopic ultrasound routinely guides lymph node evaluation for the staging of a known or suspected lung cancer. Characteristics seen on B-mode imaging might help observer decide nodes risk. The influence nodal size predictivity these characteristics and agreement with which operators can combine malignancy risk prediction is to be determined. <b><i>Objectives:</i></b> We evaluated (1) if prospectively scored...
<h3>Background</h3> Enhancing anti-tumor immunity is a foundational therapeutic strategy against cancer.<sup>1</sup> The Aliya Pulsed Electric Fields (PEF) proprietary system has been shown to promote local and systemic immune activation in pre-clinical murine models through the of immunogenic cell death (ICD) release damage associated molecular patterns (DAMPs) tumor-specific antigens.<sup>2 3</sup> Unlike apoptosis, often immunosuppressive, ICD mechanisms generate potent response by...
: As the first sentinel lymph nodes (SLN) in lung cancer are most likely to harbor metastasis, their non-invasive identification could have a significant role future treatments. We investigated feasibility of adding an SLN procedure diagnostic navigation bronchoscopy.
<b>Introduction:</b> Technology such as electromagnetic navigation technology (EMN) or radial EBUS mini probes (r-EBUS) have helped greatly in gaining access to peripheral pulmonary lesions, but reported pooled yield remains around 70%. An even lower diagnostic is lesions <2cm. In this prospective trial, we evaluated if addition of cone beam CT (CBCT) could be added value EMN and r-EBUS increasing yield. <b>Methods:</b> All patients who had an indication for diagnosis their lesion were...