A5053996737- Ear Surgery and Otitis Media
- Respiratory and Cough-Related Research
- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Tracheal and airway disorders
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Obstructive Sleep Apnea Research
- Esophageal Cancer Research and Treatment
- Sinusitis and nasal conditions
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Hearing Loss and Rehabilitation
- Delphi Technique in Research
- Pediatric health and respiratory diseases
- Prostate Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Vestibular and auditory disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Gastric Cancer Management and Outcomes
- Nasal Surgery and Airway Studies
- Streptococcal Infections and Treatments
- Meningioma and schwannoma management
- Prostate Cancer Treatment and Research
- Congenital Diaphragmatic Hernia Studies
Radboud University Nijmegen
2015-2024
Radboud University Medical Center
2015-2024
University of Twente
2024
University Medical Center
2011-2023
Radboud Institute for Molecular Life Sciences
2015-2023
Kilimanjaro Christian Medical Centre
2023
University Hospital and Clinics
2022
Rogers (United States)
2021
Evidence (Italy)
2018
Government of Western Australia Department of Health
2018
Systematic Reviews (SRs) of experimental animal studies are not yet common practice, but awareness the merits conducting such SRs is steadily increasing. As intervention differ from randomized clinical trials (RCT) in many aspects, methodology for needs to be adapted and optimized studies. The Cochrane Collaboration developed a Risk Bias (RoB) tool establish consistency avoid discrepancies assessing methodological quality RCTs. A similar initiative warranted field experimentation.We provide...
There is growing interest to implement multiparametric magnetic resonance imaging (mpMRI) and MR-guided biopsy (MRGB) for biopsy-naïve men with suspected prostate cancer.Primary objective was compare evaluate an MRI pathway a transrectal ultrasound-guided (TRUSGB) in prostate-specific antigen levels of ≥3ng/ml.A prospective, multicenter, powered, comparative effectiveness study included 626 patients (from February 2015 2018).All underwent prebiopsy mpMRI followed by systematic TRUSGB. Men...
Respiratory syncytial virus (RSV) infection is associated with subsequent recurrent wheeze. Observational studies cannot determine whether RSV the cause of wheeze or first indication preexistent pulmonary vulnerability in preterm infants. The monoclonal antibody palivizumab has shown efficacy preventing severe high-risk infants.In double-blind, placebo-controlled MAKI trial, we randomly assigned 429 otherwise healthy infants born at a gestational age 33 to 35 weeks receive either monthly...
Measures of interaction on an additive scale (relative excess risk due to [RERI], attributable proportion [AP], synergy index [S]), were developed for factors rather than preventive factors. It has been suggested that should be recoded before calculating these measures. We aimed show measures are problematic with prior recoding, and clarify the recoding method used circumvent problems. Recoding done such stratum lowest becomes reference category when both considered jointly (rather one at a...
Respiratory syncytial virus (RSV) is the most important pathogen causing severe lower respiratory tract infection (LRTI) in infants. Epidemiologic and basic studies suggest that vitamin D may protect against RSV LRTI.To determine association between plasma concentrations at birth subsequent risk of LRTI.A prospective cohort study was performed healthy term neonates. Concentrations 25-hydroxyvitamin (25-OHD) cord blood were related to LRTI first year life, defined as parent-reported symptoms...
To update, clarify, and extend IDEAL concepts recommendations.New surgical procedures, devices, other complex interventions need robust evaluation for safety, efficacy, effectiveness. Unlike new medicines, there is no internationally agreed pathway generating analyzing data throughout the life cycle of innovations. The Framework Recommendations were designed to provide this they have been used increasingly since their introduction in 2009. Based on a Delphi survey, expert workshop major...
Points• Systematic reviews are most commonly based on aggregate data extracted from publications or obtained trial investigators.• involving the central collection and analysis of individual participant (IPD) usually larger-scale, international, collaborative projects that can bring about substantial improvements to quantity quality data, give greater scope in analyses, provide more detailed robust results.• The process collecting, checking, analysing IPD is complex than for not all...
To investigate the morbidity that is associated with learning curve of minimally invasive esophagectomy.Although curves have been described, it currently unknown how much extra technically challenging surgical procedures.Prospectively collected data were retrospectively analyzed all consecutive patients undergoing Ivor Lewis esophagectomy in 4 European expert centers. The primary outcome parameter was anastomotic leakage. Secondary parameters operative time and textbook ("optimal outcome")....
Increases in human population size, dengue vector-density and mobility cause rapid spread of virus Indonesia. We investigated the changes haemorrhagic fever (DHF) incidence Indonesia over a 45-year period determined age-specific trends annual DHF incidence.Using an on-going nationwide surveillance program starting 1968, we evaluated all cases related deaths longitudinally up to 2013. Population demographics were used calculate case fatality ratios (CFRs). Age-specific data on available from...