A5033196820- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- MRI in cancer diagnosis
- Breast Lesions and Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- AI in cancer detection
- Radiopharmaceutical Chemistry and Applications
- Hernia repair and management
- Molecular Biology Techniques and Applications
- Pelvic floor disorders treatments
- Bladder and Urothelial Cancer Treatments
- Environmental Impact and Sustainability
- Digital Radiography and Breast Imaging
- Radiation Therapy and Dosimetry
- Peptidase Inhibition and Analysis
- Cancer Treatment and Pharmacology
- Cardiac Imaging and Diagnostics
- Genital Health and Disease
- Environmental Policies and Emissions
- Diverticular Disease and Complications
- Colorectal Cancer Screening and Detection
- Pelvic and Acetabular Injuries
- Cancer Genomics and Diagnostics
Radboud University Nijmegen
2007-2024
Radboud University Medical Center
2016-2024
Robert Bosch (Netherlands)
2018
Nieuwegein Fonds
2018
University Medical Center
2016
Zero to Three
2007
Maastricht University
2007
Catharina Ziekenhuis
2007
Instituut Verbeeten
2007
Eindhoven Cancer Registry
2007
There is growing interest to implement multiparametric magnetic resonance imaging (mpMRI) and MR-guided biopsy (MRGB) for biopsy-naïve men with suspected prostate cancer.Primary objective was compare evaluate an MRI pathway a transrectal ultrasound-guided (TRUSGB) in prostate-specific antigen levels of ≥3ng/ml.A prospective, multicenter, powered, comparative effectiveness study included 626 patients (from February 2015 2018).All underwent prebiopsy mpMRI followed by systematic TRUSGB. Men...
To make magnetic resonance imaging (MRI) more accessible to men at risk of high-grade prostate cancer (PCa), there is a need for quicker, simpler, and less costly MRI protocols. compare the diagnostic performance monoplanar ("fast" biparametric [bp-MRI]) triplanar noncontrast bp-MRI with that current contrast-enhanced multiparametric (mp-MRI) in detection PCa biopsy-naïve men. A prospective, multireader, head-to-head study included 626 men, between February 2015 2018. Men underwent prebiopsy...
There is large variability among radiologists in their detection of clinically significant (cs) prostate cancer (PCa) on multiparametric magnetic resonance imaging (mpMRI).To reduce the interpretation and achieve optimal accuracy assessing mpMRI.How mpMRI can be optimized demonstrated here. Whereas part 1 "surgery-in-motion" paper focused acquisition, this shows correlation between (ab)normal anatomical structures image characteristics mpMRI, how standardized according to Prostate Imaging...
Abstract Objectives To assess the diagnostic performance of 3D automated breast ultrasound (3D-ABUS) in cancer screening a clinical setting. Materials and methods All patients who had 3D-ABUS between January 2014 2022 for were included this retrospective study. The images reported by 1 6 radiologists based on Breast Imaging Reporting Data Systems (BI-RADS). was reviewed together with digital tomosynthesis (DBT). Recall rate, biopsy positive predictive value (PPV) detection yield calculated....
To compare clinically significant prostate cancer (csPCa) detection rates between magnetic resonance imaging (MRI)–transrectal ultrasound (TRUS) fusion-guided biopsy (FGB) and direct in-bore MRI-guided (MRGB). We performed a comparison of csPCa FGB MRGB. Included patients had (1) at least one prior negative TRUS biopsy; (2) Prostate Imaging Reporting Data System (PI-RADS) 4 or 5 lesion (3) size ≥8 mm measured in direction. considered Gleason score ≥7 being csPCa. Descriptive statistics with...
To determine the proportion of men avoiding biopsy because negative multiparametric magnetic resonance imaging (mpMRI) findings in a prostate MRI expert centre, and to assess number clinically significant cancers (csPCa) detected during follow-up.Retrospective study 4259 consecutive having mpMRI between January 2012 December 2017, with either history previous transrectal ultrasonography-guided or naïve. Patients underwent referral centre. Lesions were classified according Prostate Imaging...
Abstract BACKGROUND. The objectives of this study were to the probability local control after breast‐conserving therapy (BCT) in a large population patients with early‐stage breast cancer aged ≤40 years and determine which factors had prognostic value. METHODS. All (n = 758) clinical stage I or II who underwent BCT general hospitals southern part Netherlands between 1988 2002 selected for current analysis. included excision tumor followed by irradiation breast. Of 758 patients, 329 (43%)...
Abstract Aim This study compared the diagnostic capabilities of dynamic magnetic resonance defaecography (D‐ MRI ) with conventional ( CD , reference standard) in patients symptoms prolapse posterior compartment pelvic floor. Method Forty‐five consecutive underwent and D‐ . Outcome measures were presence or absence rectocele, enterocele, intussusception, rectal descent anorectal junction on straining, measured millimetres. Cohen's Kappa, sensitivity, specificity, positive predictive value...
Abstract 68 Ga-PSMA PET/CT is an imaging technique used in staging and detection of prostate cancer. However, enhanced uptake on scan has also been ascribed to other malignant benign lesions. We report a case 56-year-old man with treated carcinoma who had for restaging. uptakes the prostatic bed multiple subcutaneous lesions were seen. Histopathology lesion revealed angiolipoma. It important be aware existence growing amount reports unrelated
To assess the outcomes of pre-biopsy magnetic resonance imaging (MRI) pathways, as a tool in biopsy-naïve men with suspicion prostate cancer, routine clinical practice. Secondary included comparison transrectal MRI-directed biopsy (TR-MRDB) and transperineal (TP)-MRDB suspicious MRI.We retrospectively assessed two-centre cohort consecutive cancer who underwent Prostate Imaging-Reporting Data System version 2 (PI-RADS v2) compliant MRI single, high-volume centre between 2015 2019 (Centre 1)....
Abstract Objectives Vacuum-assisted biopsy (VAB) of the breast seems unsuitable for rapid processing due to large size. We tested microwave-based acceleration. Methods As a proof-of-principle study, 9-gauge VAB specimens were taken from eight mastectomy specimens. Forty-two processed. Quality H&E was evaluated in 84 slides, and estrogen receptor (ER), progesterone (PR), E-cadherin, human epidermal growth factor 2 (HER2) stains six slides. Preoperative used as control. Results Diagnostic...
You have accessJournal of UrologyProstate Cancer: Detection & Screening II1 Apr 2018PD23-03 THE FUTURE TRIAL; A RCT ON MRI TARGETED PROSTATE BIOPSY. COMPARISON OF AND SYSTEMATIC BIOPSY OUTCOMES. Leonie Exterkate, Olivier Wegelin, Harm van Melick, Jelle Barentsz, Marloes der Leest, Alain Kummer, Willem Vreuls, Peter de Bruin, Ruud Bosch, and Rik Somford ExterkateLeonie Exterkate More articles by this author , WegelinOlivier Wegelin MelickHarm Melick BarentszJelle Barentsz LeestMarloes Leest...
Ziel/Aim Prostate mpMRI is an effective tool to discriminate between healthy and malignant prostate tissue. However, due the high rate of equivocal lesions false-positive findings, has room for improvement. This could be provided by PSMA PET. In this setting, [18F]PSMA-1007 particular interest low renal excretion. The present study aimed investigate role PET/CT following aid in detection local tumors.
Approximately 5% of women diagnosed as having invasive breast cancer are less than 40 years age. At present, breast-conserving therapy (BCT) is generally accepted an alternative to mastectomy for treating early-stage disease; it reportedly enhances body image and sexual functioning. In many studies, however, young have the highest risk developing locally recurrent disease following BCT. This study examined prognostic factors in achieving local control 758 aged younger who underwent BCT stage...