A5002901679- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Prostate Cancer Treatment and Research
- Radiation Therapy and Dosimetry
- Advanced X-ray and CT Imaging
- Medical Image Segmentation Techniques
- Colorectal Cancer Surgical Treatments
- Medical Imaging and Analysis
- Lung Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Radiation Dose and Imaging
- Endometrial and Cervical Cancer Treatments
- Cardiomyopathy and Myosin Studies
- Advanced Neuroimaging Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Urologic and reproductive health conditions
- Lipid Membrane Structure and Behavior
- Glioma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Atomic and Subatomic Physics Research
The Netherlands Cancer Institute
2016-2025
Leiden University Medical Center
2017-2025
Dutch Cancer Society
2011-2024
Leiden University
2024
Oncode Institute
2013-2022
University Medical Center Utrecht
2006-2021
Radboud University Nijmegen
2009-2021
Radboud University Medical Center
2021
Hospital de Sant Pau
2015
University of Toronto
2014
An automatic method for delineating the prostate (including seminal vesicles) in three‐dimensional magnetic resonance scans is presented. The based on nonrigid registration of a set prelabeled atlas images. Each image nonrigidly registered with target patient image. Subsequently, deformed label images are fused to yield single segmentation proposed evaluated 50 clinical scans, which were manually segmented by three experts. Dice similarity coefficient (DSC) used quantify overlap between and...
This study investigates whether focal boosting of the macroscopic visible tumor with external beam radiotherapy increases biochemical disease-free survival (bDFS) in patients localized prostate cancer.In phase III, multicenter, randomized controlled Focal Lesion Ablative Microboost Prostate Cancer trial, 571 intermediate- and high-risk cancer were enrolled between 2009 2015. Patients assigned to standard treatment received 77 Gy (fractions 2.2 Gy) entire prostate. The boost arm an additional...
A phase III multi-centre randomised trial (ROSEL) has been initiated to establish the role of stereotactic radiotherapy in patients with operable stage IA lung cancer. Due rapid changes technology and evolving techniques for image-guided delivery, guidelines had be developed order ensure uniformity implementation this study. Quality Assurance Working Party was formed by radiation oncologists clinical physicists from both academic as well non-academic hospitals that already implemented...
In a multi-atlas based segmentation procedure, propagated atlas segmentations must be combined in label fusion process. Some current methods deal with this problem by using selection to construct an set either prior or after registration. Other estimate the performance of and use as weight This paper proposes selective iterative method for level estimation (SIMPLE), which combines both strategies procedure. subsequent iterations refines estimated selected atlases. For dataset 100 MR images...
The treatment results of external beam radiotherapy for intermediate and high risk prostate cancer patients are insufficient with five-year biochemical relapse rates approximately 35%. Several randomized trials have shown that dose escalation to the entire improves disease free survival. However, further whole gland is limited due an unacceptable acute late toxicity. Moreover, local recurrences often originate at location macroscopic tumor, so boosting radiation tumor within might increase...
Magnetic Resonance linear accelerator (MR-linac) systems represent a new type of technology that allows for online MR-guidance high precision radiotherapy (RT). Currently, the first MR-linac installations are being introduced clinically. Since imaging performance these integrated is critical their application, thorough commissioning MRI essential. However, guidelines on MR-guided RT not yet defined and data MR-linacs available.Here we describe comprehensive protocol, which contains standard...
Boosting the dose to largest (dominant) lesion in radiotherapy of prostate cancer may improve treatment outcome. The success this approach relies on detection and delineation tumors. agreement among teams radiation oncologists radiologists delineating lesions multiparametric magnetic resonance imaging (mp-MRI) was assessed by measuring distances between observer contours. accuracy determined using whole-mount histopathology specimens as reference.Six delineated tumors mp-MRI 20 patients who...
Purpose: MR-guided Radiation Therapy (MRgRT) allows for high-precision radiotherapy under real-time MR visualization. This enables margin reduction and subsequent dose escalation which may lead to higher tumor control less toxicity. The Unity MR-linac (Elekta AB, Stockholm, Sweden) integrates a linear accelerator with 1.5T diagnostic quality MRI an online adaptive workflow. A prospective international registry was established facilitate the evidence-based implementation of into clinical...
PurposeTo compare toxicity rates in patients with localized prostate cancer treated standard fractionated external beam radiotherapy (EBRT) or without an additional integrated boost to the macroscopically visible tumour.Material and methodsFLAME is a phase 3 multicentre RCT (NCT01168479) of pathologically confirmed intermediate high-risk cancer. The treatment arm (n = 287) received dose entire 77 Gy 35 fractions. dose-escalated 284) fractions prostate, up 95 multi-parametric MRI-defined...