A5101398849- Growth Hormone and Insulin-like Growth Factors
- Advanced Radiotherapy Techniques
- Bariatric Surgery and Outcomes
- Nutrition and Health in Aging
- Diet and metabolism studies
- Body Composition Measurement Techniques
- Gamma-ray bursts and supernovae
- Prostate Cancer Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Parathyroid Disorders and Treatments
- Diabetes Treatment and Management
- Electrolyte and hormonal disorders
- Hormonal and reproductive studies
- Cardiac Arrhythmias and Treatments
- Anesthesia and Pain Management
- Electrical and Bioimpedance Tomography
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Radiation Therapy and Dosimetry
- Metabolism, Diabetes, and Cancer
- Pharmacology and Obesity Treatment
- Vitamin D Research Studies
- Medical Imaging Techniques and Applications
- Astrophysics and Cosmic Phenomena
University Medical Center Utrecht
2019-2024
Rijnstate Hospital
2015-2024
Victorian Institute of Forensic Medicine
2024
Check Point (Israel)
2023
Franco-British Council
2023
Hôpital Bichat-Claude-Bernard
2022
Technical University of Munich
2022
Université Claude Bernard Lyon 1
2022
Martini Ziekenhuis
2009-2021
Royal Surrey NHS Foundation Trust
2021
view Abstract Citations (396) References (29) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS Instrument Description and Performance of the Imaging Gamma-Ray Telescope COMPTEL aboard Compton Observatory Schoenfelder, V. ; Aarts, H. Bennett, K. de Boer, Clear, J. Collmar, W. Connors, A. Deerenberg, Diehl, R. von Dordrecht, den Herder, Hermsen, Kippen, M. Kuiper, L. Lichti, G. Lockwood, Macri, McConnell, Morris, D. Much, Ryan, Simpson, Snelling, Stacy, Steinle,...
Recent data indicated a high incidence of inappropriate management neuromuscular block, with rate residual paralysis and relaxant-associated postoperative complications. These are alarming in that the available monitoring, as well myorelaxants their antagonists basically allow tolerated blockade. In this first European Society Anaesthesiology Intensive Care (ESAIC) guideline on peri-operative we aim to present aggregated evidence-based recommendations assist clinicians provide best medical...
To assess the implications of prolonged growth hormone deficiency (GHD) for acquisition and maintenance bone mass, mineral density (BMD) was measured in 70 adult males (mean age 26.7 +/- 4.5 years) with childhood-onset GHD, 7.4 4.2 years after discontinuation previous GH therapy. Because most these patients were short height 165.8 6.6 cm), influence body on standard BMD measurements, conventionally reported as areal (BMDarea, expressed g/cm2), analyzed a group age-matched healthy males. In...
Reversal of rocuronium-induced neuromuscular blockade can be accomplished by chemical encapsulation rocuronium sugammadex, a modified gamma-cyclodextrin derivative. This study investigated the efficacy and safety sugammadex in reversing profound at 5 min American Society Anesthesiologists physical status I II patients.Forty-five patients (aged 18-64 yr) scheduled to undergo surgical procedures (anticipated anesthesia duration >/= 90 min) were randomly assigned phase II, multicenter,...
Anthropometry and bioimpedance analysis (BIA) were used to assess body composition in 42 GH-deficient (GHD) adult males (mean age, 27.2 +/- 4.7 yr). During childhood, all patients had received GH treatment for a mean period of 8.4 3.8 yr. At the start this study, therapy been discontinued 7.5 4.5 Eighteen isolated deficiency (I-GHD). Twenty-four multiple pituitary hormone deficiencies (M-PHD), substituted adequately. Compared age- sex-matched controls, sum skinfolds measured at 7 different...
The optimal dose for GH replacement therapy in GH-deficient (GHD) adults is not known, nor there a consensus as to which method the most appropriate monitoring of treatment. To establish general guideline adults, we evaluated relationship between administered and achieved serum levels three GH-dependent markers. Serum insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), acid-labile subunit (ALS) were measured 46 GHD men participating 1-yr, double blind, placebo-controlled...
The objective of this study was to evaluate the safety and effect recombinant exogenous growth hormone (GII) on nitrogen production in patients with severe sepsis. It designed as a prospective, randomized, placebo-controlled trial, performed medical intensive care unit university hospital. Twenty admitted septic shock receiving standard parenteral nutrition served subjects. Treatment consisted GH 0.1 mg/kg/day or placebo administered continuous intravenous infusion second, third, fourth days...
Short term GH replacement therapy has been shown to improve body composition and exercise capacity. It is not yet known whether remains beneficial over the long term. We assessed effects of on composition, bone mineral density, cardiac function. Thirty-eight men with childhood-onset deficiency were studied for a period 3–5 yr. Measurements included anthropometry, computed tomographic scanning abdomen upper leg, densitometry, echo cardiography, bicycle ergometry. The initial dose 1–3...
Isolated hypogonadotropic hypogonadism (IHH) is frequently observed in severely obese men, probably as a result of increased estradiol (E(2)) production and E(2)-mediated negative feedback on pituitary LH secretion. Aromatase inhibitors can reverse this process. This study evaluates whether letrozole once week normalize serum testosterone men maintain its long term effect.Open, uncontrolled 6-month pilot 12 (body mass index>35.0 kg/m(2)) with obesity-related IHH free levels <225 pmol/l,...
Severe vitamin D deficiency is very common. Evidence-based guidelines for rapid correction with high-dose oral cholecalciferol are not yet available.To develop a practical loading dose regimen.A total of 208 D-deficient subjects (serum 25-hydroxyvitamin D(3) (25-OHD(3)) level <50 nmol/l), aged 18-88 years, were treated solubilized cholecalciferol, 50,000 IU/ml. They received either 25,000 IU every fortnight 8 weeks (total 100,000 IU), week 6 150,000 or 25 000 200,000 IU). Blood samples...
The efficacy and safety of various modes medical treatment for primary hyperparathyroidism (PHPT) in pregnancy is largely unknown. This report describes two cases PHPT that were temporarily treated with the calcimimetic cinacalcet. first case was diagnosed 31st week pregnancy. patient asymptomatic had an albumin-corrected total calcium level (Ca(corr)) 3.24 mmol/l. As serum only mildly elevated it decided to postpone surgery postpartum period. Cinacalcet started immediately after delivery...
Morbid obesity is associated with increased estradiol production as a result of aromatase-dependent conversion testosterone to estradiol. The elevated serum levels may inhibit pituitary LH secretion such extent that hypogonadotropic hypogonadism can result. Normalization the disturbed estradiol-testosterone balance be beneficial reverse adverse effects hypogonadism.To examine whether aromatase inhibition Letrozole normalize in severely obese men hypogonadism.Ten men, mean age 48.2 +/- 2.3...
Abstract. Familial benign hypocalciuric hypercalcaemia (FHH) results from a heterozygous inactivating mutation of the calcium‐sensing receptor (CaR) and is characterized by hypercalcaemia, hypocalciuria inappropriately normal plasma levels parathyroid hormone. In minority patients, loss function CaR in severe associated with complications for which no effective surgical or medical treatment available. We investigated effects calcimimetic agent cinacalcet, an allosteric modulator CaR,...
Severe vitamin D deficiency is a common finding in morbid obesity, and the incidence increases markedly after RYGB. Normalization of levels RYGB difficult to achieve because degree surgery-induced malabsorption not known.To develop test that quantifies changes intestinal cholecalciferol absorption induced by Roux-en-Y gastric bypass (RYGB) surgery.Absorption characteristics were studied 14 morbidly obese, premenopausal women before 4 weeks laparoscopic Serum measured at baseline 1, 2, 3,...