A5013326343- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Colorectal Cancer Surgical Treatments
- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
Radboud University Nijmegen
2007-2021
Radboud University Medical Center
2007-2021
PurposeTo compare toxicity rates in patients with localized prostate cancer treated standard fractionated external beam radiotherapy (EBRT) or without an additional integrated boost to the macroscopically visible tumour.Material and methodsFLAME is a phase 3 multicentre RCT (NCT01168479) of pathologically confirmed intermediate high-risk cancer. The treatment arm (n = 287) received dose entire 77 Gy 35 fractions. dose-escalated 284) fractions prostate, up 95 multi-parametric MRI-defined...
For irradiation of localized prostate-cancer, moderately-hypofractionated regimens with a variety dose per fraction are used. We adopted regimen 70 Gy in 28 fractions 2.5 Gy, using state the art radiotherapy (RT) and closely monitored efficacy, toxicity health-related quality life (HRQoL) large cohort, patient-reported outcomes.Between 2008 2016, 462 patients intermediate- to high-risk prostate cancer were treated RT, IMRT/VMAT, an online fiducial-maker based correction protocol daily...
_____________________________________________________________________________________________________symptomatic pseudo-progression after SRT of brain metastases needs to be considered as a serious radiation induced toxicity.Reduction the high dose volume normal tissue may prevent this toxicity.