A5103133513- Cancer Risks and Factors
- Breast Cancer Treatment Studies
- Nutritional Studies and Diet
- Global Cancer Incidence and Screening
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- Cancer survivorship and care
- Obesity, Physical Activity, Diet
- Digital Radiography and Breast Imaging
- MRI in cancer diagnosis
- Nutrition and Health in Aging
- AI in cancer detection
- Colorectal Cancer Screening and Detection
- Birth, Development, and Health
- Physical Activity and Health
- Menopause: Health Impacts and Treatments
- Phytoestrogen effects and research
- Diet and metabolism studies
- Radiomics and Machine Learning in Medical Imaging
- Breast Implant and Reconstruction
- Cancer, Lipids, and Metabolism
- Hormonal and reproductive studies
- Endometrial and Cervical Cancer Treatments
- Epigenetics and DNA Methylation
- Behavioral Health and Interventions
University Medical Center Utrecht
2012-2021
Utrecht University
2007-2021
Oklahoma State University Center for Health Sciences
2004-2019
Imperial College London
2008-2019
MRC Centre for Environment and Health
2017
National Institute for Public Health and the Environment
2006-2012
Radboud University Nijmegen
1989-2012
Radboud University Medical Center
2010-2012
University Medical Center
2003-2010
Imperial Valley College
2010
Extremely dense breast tissue is a risk factor for cancer and limits the detection of with mammography. Data are needed on use supplemental magnetic resonance imaging (MRI) to improve early reduce interval cancers in such patients.In this multicenter, randomized, controlled trial Netherlands, we assigned 40,373 women between ages 50 75 years extremely normal results screening mammography group that was invited undergo MRI or received only. The groups were 1:4 ratio, 8061 MRI-invitation...
A later menopause has been associated with a decreased cardiovascular risk but an increased for breast and endometrial cancer. The net effect on mortality is unclear. We determined the association of age at longevity balance between cancer mortality.We analyzed data from screening cohort comprising 12,134 postmenopausal women followed average 17 years. used Cox proportional hazards models life tables to calculate expectancy Dutch woman 50.During 204,024 person-years, there were 2607 deaths,...
Background. In a pilot study for the European Prospective Investigation into Cancer and Nutrition (EPIC) modification of Baecke questionnaire on physical activity was tested repeatability relative validity in population 134 men women aged 20–70 years. Methods. For assessment Pearson's correlation coefficients percentages agreement after classification tertiles were computed between administrations at baseline, 5 11 months. Relative determined by comparing to four times repeated 3-day diary....
Abstract Background: Serum antimüllerian hormone (AMH) levels are highly correlated with antral follicle counts, while being menstrual cycle independent and easily measurable. However, AMH, unlike has not been tested as yet a predictor of reproductive status. By relating AMH to the age distribution events like onset menopause, we this hypothesis. Methods: were measured in 144 fertile normal volunteers used determine an estimate mean function age. Data on menopause obtained from...
Phytoestrogens are plant compounds that structurally and functionally similar to mammalian estrogens. By competing for estrogen receptors, phytoestrogens possibly inhibit binding of the more potent endogenous estrogens decrease their potential effects on breast cancer risk. We investigated association between plasma phytoestrogen levels risk in a prospective manner.We performed nested case-control study within Prospect cohort, one two Dutch cohorts participating European Prospective...
<h3>Objective</h3> Anti-neutrophil cytoplasmic antibodies and anti-<i>Saccharomyces cerevisiae</i> mannan (ASCAs) have been detected in the serum of patients with ulcerative colitis (UC) Crohn9s disease (CD) their unaffected family members. The aim this study was to establish value serological markers as predictors UC CD. <h3>Design</h3> Individuals who developed CD or were identified from European Prospective Investigation into Cancer Nutrition (EPIC) study. At recruitment, none...
Background Helping consumers make healthier food choices is a key issue for the prevention of cancer and other diseases. In many countries, political authorities are considering implementation simplified labelling system to reflect nutritional quality products. The Nutri-Score, five-colour nutrition label, derived from Nutrient Profiling System British Food Standards Agency (modified version) (FSAm-NPS). How consumption foods with high/low FSAm-NPS relates risk has been studied in...
PurposeTo compare toxicity rates in patients with localized prostate cancer treated standard fractionated external beam radiotherapy (EBRT) or without an additional integrated boost to the macroscopically visible tumour.Material and methodsFLAME is a phase 3 multicentre RCT (NCT01168479) of pathologically confirmed intermediate high-risk cancer. The treatment arm (n = 287) received dose entire 77 Gy 35 fractions. dose-escalated 284) fractions prostate, up 95 multi-parametric MRI-defined...
Women with extremely dense breasts have an increased risk of breast cancer and lower mammographic tumor detectability. Nevertheless, in most countries, these women are currently screened mammography only. Magnetic resonance (MR) imaging has the potential to improve detection at early stage because its higher sensitivity. However, MR is more expensive expected be accompanied by increase number false-positive results and, possibly, overdiagnosis. To study additional value imaging, a randomized...
The association between single health behaviours and incidence of premature mortality from major chronic diseases, including myocardial infarction, stroke, diabetes mellitus, cancer, has been demonstrated thoroughly. However, the several healthy with Disability-Adjusted Life Years (DALYs), which is a measure for total combining Lost due to Disability mortality, not studied yet. A prospective cohort study was conducted among 33,066 men women aged 20 70 years recruited into EPIC-NL during 1993...
Abstract Background Increasing evidence suggests that severe skeletal muscle index (SMI) loss (sarcopenia) is associated with poor overall survival in metastatic colorectal cancer patients, but its mechanisms are unknown. We recently found, using data of the randomized phase 3 CAIRO3 study, SMI was related shorter time to disease progression and during first‐line maintenance treatment capecitabine + bevacizumab (CAP‐B) or observation more intensive oxaliplatin (CAPOX‐B) reintroduction...
Background: Data from animal models suggest that caloric restriction may reduce the risk of breast cancer, although not all dietary regimens produce similar effects. We examined whether imposed as a consequence 1944–1945 Dutch famine reduced cancer in women participating screening program. Methods: Between 1983 and 1986, approximately 15 000 women, aged 2 to 33 years during famine, responded questionnaire about their experience. A exposure score, graded absent, moderate, or severe exposure,...
Breast cancer risk increases with increased levels of alcohol consumption, potentially through an effect on sex hormone levels. In a cross-sectional study among Dutch participants (n = 17,357) the European Prospective Investigation into Cancer and Nutrition conducted in Utrecht, The Netherlands (Prospect-EPIC), we investigated relation between intake estrogen androgen Alcohol was calculated from food frequency questionnaire. Women were included if they postmenopausal, had donated blood...
Abstract Background In epidemiological research, physical activity is usually assessed by questionnaires. Questionnaires are suitable for large study populations since they relatively inexpensive and not very time consuming. However, questionnaire information definition subjective prone to recall bias, especially among elderly subjects. The Modified Baecke Questionnaire, developed Voorrips coworkers, measures habitual in the elderly. includes questions on household activities, sports,...