A5038387390- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Colorectal Cancer Surgical Treatments
- Effects of Radiation Exposure
- Radiopharmaceutical Chemistry and Applications
- Genital Health and Disease
- Cannabis and Cannabinoid Research
- Dental Implant Techniques and Outcomes
- Cancer, Hypoxia, and Metabolism
- Forensic Toxicology and Drug Analysis
- Nonmelanoma Skin Cancer Studies
- Cancer Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- South Asian Cinema and Culture
- Lymphatic System and Diseases
- Gender, Feminism, and Media
- Facial Trauma and Fracture Management
- Urban Planning and Governance
- Ocular and Laser Science Research
Jessa Hospital
2016-2023
University of Amsterdam
2018-2022
KU Leuven
2011-2020
The Netherlands Cancer Institute
2013
Zero to Three
2012
Universitair Ziekenhuis Leuven
2011
Instituut Verbeeten
2011
Province of Antwerp
1993
This study investigates whether focal boosting of the macroscopic visible tumor with external beam radiotherapy increases biochemical disease-free survival (bDFS) in patients localized prostate cancer.In phase III, multicenter, randomized controlled Focal Lesion Ablative Microboost Prostate Cancer trial, 571 intermediate- and high-risk cancer were enrolled between 2009 2015. Patients assigned to standard treatment received 77 Gy (fractions 2.2 Gy) entire prostate. The boost arm an additional...
Abstract Purpose: To prospectively evaluate multiparametric magnetic resonance imaging (MRI) for accurate localization of intraprostatic tumor nodules, with whole‐mount histopathology as the gold standard. Materials and Methods: Seventy‐five patients biopsy‐proven, intermediate, high‐risk prostate cancer underwent preoperative T2‐weighted (T2w), dynamic contrast‐enhanced (DCE) diffusion‐weighted (DW) MRI at 1.5T. Localization suspicious lesions was recorded each 24 standardized regions...
Boosting the dose to largest (dominant) lesion in radiotherapy of prostate cancer may improve treatment outcome. The success this approach relies on detection and delineation tumors. agreement among teams radiation oncologists radiologists delineating lesions multiparametric magnetic resonance imaging (mp-MRI) was assessed by measuring distances between observer contours. accuracy determined using whole-mount histopathology specimens as reference.Six delineated tumors mp-MRI 20 patients who...
PurposeTo compare toxicity rates in patients with localized prostate cancer treated standard fractionated external beam radiotherapy (EBRT) or without an additional integrated boost to the macroscopically visible tumour.Material and methodsFLAME is a phase 3 multicentre RCT (NCT01168479) of pathologically confirmed intermediate high-risk cancer. The treatment arm (n = 287) received dose entire 77 Gy 35 fractions. dose-escalated 284) fractions prostate, up 95 multi-parametric MRI-defined...
Aim. To investigate the reliability of a sentinel node (SN) procedure for nodal staging in prostate cancer (PCa) patients at high risk lymph (LN) involvement.
In patients with prostate cancer (PCa) histopathologically proven pelvic lymph node (LN) metastasis (pN1) after extended dissection (ePLND), multimodality treatment consisting of the primary tumor and whole radiotherapy (WPRT) combined androgen deprivation therapy (ADT) offers promising results, leading to better cause-specific survival rates compared ADT alone. However, in case more than one LN is invaded by tumor, approximately 40% relapse biochemically clinically. Clinical present...
Purpose: Intensity modulated radiotherapy (IMRT) and volumetric arc therapy have become standard treatments but are more sensitive to anatomical variations than 3D conformal techniques. To correct for inter- intrafraction variations, fast easy implement methods needed. Here, the authors propose a full dosimetric IMRT correction that finds compromise in-between basic repositioning (the current clinical practice) replanning. It simplifies replanning by avoiding recontouring step dose...
Aim. To investigate whether blood-based markers could be used to identify prostate cancer (PCa) patients harboring lymph node (LN) metastases. In addition, E-cadherin expression was studied within the concept of epithelial mesenchymal plasticity. Material and methods. Seventy-five with clinically localized PCa who underwent a superextended lymphadenectomy followed by radical prostatectomy (RP) were included in this study. Preoperative plasma/serum levels endoglin, transforming growth...
SummaryA case of palmar fasciitis and arthritis (PFA) is described in a man with both prolactinoma metastatic cancer the prostate. This rare condition mainly women ovarian our first reported association PFA
Preclinical and histological data show overexpression of the type 1 cannabinoid receptor (CB1R) in prostate carcinoma (PCa). In a prospective study, feasibility 18F-MK-9470 positron emission tomography (PET) imaging patients with primary metastatic PCa was evaluated.Eight were included underwent PET/CT imaging. For five PCa, dynamic performed over three acquisition intervals (0 to 30, 60 90 120 150 min post-injection). malignant benign tissue regions, time activity curves mean standardized...